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Novel ready-to-use aerogel microsphere and preparation method thereof

An airgel and microsphere technology, which is applied in the preparation of microspheres and microcapsule preparations, can solve the problems of denaturation of active substances, easy aggregation and precipitation, latex demulsification, etc.

Inactive Publication Date: 2018-09-25
广州市芯检康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the microspheres prepared by this method are easy to aggregate and precipitate after long-term storage or after the active protein is cross-linked. Once the prepared latex is frozen, melting again will cause latex demulsification and active substance denaturation.

Method used

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  • Novel ready-to-use aerogel microsphere and preparation method thereof
  • Novel ready-to-use aerogel microsphere and preparation method thereof
  • Novel ready-to-use aerogel microsphere and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0143] The ready-to-use airgel microsphere emulsion was prepared by mixing 170 nanometer size silica airgel particles (600g), poly(methyl vinyl ether / maleic acid) half ester copolymer (5.0g), absolute ethanol ( 150 ml), added to 6.7 liters of isododecane, fully ground in a magnetic grinder for later use; Hyaluronic acid elastomer (1.0g), lauryl trimethylamine oxide (1.5g), absolute ethanol (150ml), ammonia water (9.0ml), purified water (2.9L) after stirring and dissolving in a high-speed homogenizer Slowly add dropwise to the above-mentioned standby silica airgel suspension, and then quickly add it to the high-pressure jet homogenizer, use the rated (flow rate: 6L / h, working pressure: 800bar, machine stroke number: 110 times / min , maximum product temperature: 80°C) after homogenization treatment, and then three-spectrum high-energy light curing treatment, cycle twice to get the pretreated ready-to-use airgel microsphere suspension. The ready-to-use airgel microspheres can be ...

Embodiment 2

[0145] The ready-to-use airgel microsphere emulsion was prepared by mixing 110 nanometer size silica airgel particles (300g), poly(methyl vinyl ether / maleic acid) half ester copolymer (3.0g), absolute ethanol ( 300 ml), added to 7.7 liters of isododecane, bis((3,4-epoxycyclohexyl)methyl)adipate and isobornyl methacrylate in a 33:1:1 mixture, in Grind fully in a magnetic mill in the dark for later use; in addition, weigh poly-γ-glutamic acid (2.0 g), low-acyl gellan gum (0.10 g), acetylated sodium hyaluronate (0.5 g), polyethylene Pyrrolidone K90 ((4.5g)), 2,4,7,9-tetramethyl-5-decyne-4,7-diol (1.0g), ammonia (4.5ml), purified water (2.0L) high speed After the homogenizer stirs and dissolves, slowly add it dropwise to the above-mentioned standby silica airgel suspension, and then quickly add it to the high-pressure jet homogenizer, use the rated (flow rate: 6L / h, working pressure: 800bar, machine stroke number: 110 times / min, maximum product temperature: 80°C) after homogeniza...

Embodiment 3

[0147]The ready-to-use airgel microsphere emulsion was obtained by mixing 250 nanometer size silica airgel particles (450g), poly(methyl vinyl ether / maleic acid) half ester copolymer (3.0g), absolute ethanol ( 300 ml), to 6.7 liters of 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, fluorinated diphenyl titanocene and isobornyl methacrylate 1:1: 60 mixed solution, fully ground in a magnetic mill under the condition of avoiding light for later use; in addition, weigh poly-γ-glutamic acid (1.0g), high-acyl gellan gum (0.02g), sodium hyaluronate oligosaccharide (0.5 g), polyvinylpyrrolidone K60 ((3.0g)), 2,4,7,9-tetramethyl-5-decyne-4,7-diol (1.5g), ammonia water (5.5ml), purified water (2.9 liters) after stirring and dissolving with a high-speed homogenizer, slowly add it dropwise to the above-mentioned spare silica airgel suspension, and then quickly add it to the high-pressure jet homogenizer, use the rated (flow rate: 6L / h, working pressure : 800bar, number of machine ...

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Abstract

The invention relates to a ready-to-use aerogel microsphere, which uses an aerogel microsphere as a core, is coated or doped with a functional material or a functional group on the surface, and contains at least a functional material or functional group and at least an aerogel. The invention further discloses a method for producing the ready-to-use aerogel microsphere, and uses of the ready-to-useaerogel microsphere, wherein the method comprises: carrying out homogenizing or on starting aerogel particles or an aerogel preparation precursor substance by using an ultrahigh pressure jet device,or carrying out magnetic grinding or carrying out homogenizing and magnetic grinding, doping or coating with a photosensitive material / photocurable material, a functional material or a functional monomer substance or a combination thereof, and finally carrying out three-spectrum photocuring to obtain the ready-to-use aerogel microsphere material.

Description

technical field [0001] The present invention relates to biomedicine, analytical chemistry, nanometer material science, synthetic chemical technology, new material, new biotechnology, polymer polymerization reaction technology, solid phase organic synthesis, surface modification of polymer material, polymer functional microsphere Airgel ready-to-use microspheres in the field of ready-to-use airgel microspheres, airgel particles, multifunctional materials, and polymer microsphere materials, and preparation methods thereof, and applications of the airgel ready-to-use microspheres use. More specifically, the present invention relates to airgel ready-to-use microspheres coated / incorporated with functional materials. Background technique [0002] Airgel particles can have extremely low density, high porosity and small pore size. Their weight can be extremely low and they are usually formed by replacing the particles in the gel with gases. Nano-scale airgel has the characteristi...

Claims

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Application Information

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IPC IPC(8): B01J13/02
CPCB01J13/02
Inventor 周咏梅其他发明人请求不公开姓名
Owner 广州市芯检康生物科技有限公司
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