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Preparation method for moisturizing lipstick containing shikonin liposomes

A production method and technology of shikonin lipid, which are applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as difficulty in adding natural pigments, high cost of extraction of natural pigments, and affecting coloring effects, etc., to achieve increased film strength, Improve the emulsification effect, the effect of not easy to break the emulsification

Active Publication Date: 2018-09-28
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high cost of natural pigment extraction and unstable color, it is easy to be affected by various factors (such as light, temperature, oxidation, pH value, medium polarity, metal ions, additives, etc.) Changes in discoloration and other aspects affect its coloring effect, which seriously restricts the process of replacing artificial pigments with natural pigments, so the application of natural pigments in cosmetics is less at present
[0005] In addition, commercially available lipsticks are generally pure oil and do not contain moisturizing ingredients, so long-term use is likely to cause chapped lips
Most of the ingredients that can bring moisturizing effect to the skin are water-soluble substances, and it is difficult to add them to pure oil-based lipsticks

Method used

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  • Preparation method for moisturizing lipstick containing shikonin liposomes
  • Preparation method for moisturizing lipstick containing shikonin liposomes
  • Preparation method for moisturizing lipstick containing shikonin liposomes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Table 1.1

[0047]

[0048]

[0049] The steps for preparing the above-mentioned products are as follows:

[0050] (1) Preparation of shikonin liposomes: Weigh 2g of lecithin and 0.4g of cholesterol in a round bottom flask, add 500mL of petroleum ether, stir to dissolve, then add 0.4g of shikonin, and rotate under reduced pressure at 40°C Recover the organic solvent, form a uniform purple-red lipid film in the round bottom flask, then add 200mL PBS buffer solution (pH=7.4), stir and elute the lipid film for 1 hour, sonicate in a water bath at 25°C for 5 minutes, filter with a 0.45 μm microporous membrane, Stand still for 10 minutes, repeat ultrasonic and filter membrane filtration under the same conditions, use a spray dryer to spray dry the obtained product at an inlet temperature of 110°C, and obtain 1.2 g of shikonin liposome;

[0051] (2) Beeswax, carnauba wax, microcrystalline wax, jojoba oil, avocado oil, squalane, oleyl erucate, polyhydroxystearic acid, ce...

Embodiment 2

[0076] Table 2.1

[0077]

[0078]

[0079] The steps for preparing the above-mentioned products are as follows:

[0080] (1) Preparation of shikonin liposomes: Weigh 1.5g lecithin and 0.25g cholesterol in a round bottom flask, add 300mL petroleum ether, stir to dissolve, then add 0.5g shikonin, spin under reduced pressure at 50°C Evaporate and recover the organic solvent, and form a uniform purple-red lipid film in the round bottom flask, then add 180mL 0.9% NaCl solution, stir and elute the lipid film for 2 hours, ultrasonicate in a water bath at 26°C for 10 minutes, filter with a 0.45 μm microporous membrane, and stand for 5 minutes , repeated ultrasonication and filter membrane filtration under the same conditions, using a spray dryer to spray dry the obtained product at an inlet temperature of 130° C. to obtain 1 g of shikonin liposome;

[0081] (2) Carnauba wax, microcrystalline wax, candelilla wax, avocado oil, macadamia nut oil, polyhydroxystearic acid, cetyl et...

Embodiment 3

[0102] chart 3.1

[0103]

[0104]

[0105]

[0106] The steps for preparing the above-mentioned products are as follows:

[0107] (1) Preparation of shikonin liposomes: Weigh 2.1g lecithin and 0.4g cholesterol in a round bottom flask, add 450mL petroleum ether, stir to dissolve, then add 0.3g shikonin, spin under reduced pressure at 45°C Evaporate and recover the organic solvent, and form a uniform purple-red lipid film in the round bottom flask, then add 200mL 0.9% NaCl solution, stir and elute the lipid film for 2 hours, ultrasonicate in a water bath at 28°C for 8 minutes, filter with a 0.45μm microporous membrane, and let stand for 10 minutes , repeated ultrasonication and membrane filtration under the same conditions, using a spray dryer to spray dry the obtained product at an inlet temperature of 120°C to obtain 1.5 g of shikonin liposomes;

[0108] (2) Beeswax, microcrystalline wax, candelilla wax, jojoba oil, macadamia nut oil, polyhydroxystearic acid, octyld...

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Abstract

The invention discloses a preparation method for a moisturizing lipstick containing shikonin liposomes. The formula comprises 9-11% of shikonin liposomes, 48-52% of component A, 25-28% of oil-based component B, 6-9% of water, 0.5-1% of polysaccharide and 4-6% of emulsifiers. The preparation method comprises the steps that (1) the shikonin liposomes are prepared; (2) the component A is prepared, specifically, the component A is selected from a waxy component and / or an oil-based component A; (3) the component A and the shikonin liposomes are heated and mixed in proportion to obtain a mixture A;(4) the oil-based component B is prepared; (5) an aqueous moisturizer is prepared, specifically, the aqueous moisturizer is a mixture of the water and the polysaccharide; (6) the emulsifiers are prepared; (7) the oil-based component B and the aqueous moisturizer are slowly stirred and mixed, the emulsifiers are added and stirred uniformly, a stabilizing emulsion is obtained, and the temperature ismaintained at 75-85 DEG C to obtain a mixture B; (8) the mixture A and the mixture B are mixed and stirred uniformly; and (9) the mixture obtained in the step (8) is subjected to injection molding at75-85 DEG C and cooled to room temperature for demoulding to obtain a product.

Description

(1) Technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a method for making moisturizing lipstick. (2) Technical background [0002] Lipstick is a kind of lip cosmetic widely used by women every day. It can make lips rosy and shiny, moisturize, protect lips, increase facial beauty and correct lip contour. It is one of the essential beauty cosmetics for women. [0003] The colorant in lipstick is a substance that gives lips a bright lip color. Traditional lipsticks generally use artificial pigments as colorants to add to lipsticks. However, these synthetic pigments have certain toxicity, which originates from the arsenic, lead, copper, phenol, aniline, ether, chloride and sulfate in the synthetic pigments, which can cause different degrees of harm to the human body. Ingestion also has the possibility of teratogenicity and carcinogenicity, which may cause certain damage to the body of consumers who use lipstick for a long time....

Claims

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Application Information

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IPC IPC(8): A61K8/35A61K8/14A61K8/73A61K8/39A61K8/49A61Q1/06A61Q19/00
CPCA61K8/14A61K8/355A61K8/39A61K8/4973A61K8/73A61K8/735A61K8/736A61Q1/06A61Q19/001
Inventor 邵平冯洁茹朱庆牛犇
Owner ZHEJIANG UNIV OF TECH
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