Lutein/lutein ester microparticles and preparation method thereof

A technology of lutein ester and lutein, which can be used in pharmaceutical formulations, ester active ingredients, and cosmetic preparations, etc., can solve problems such as environmental and staff injuries, and achieve solutions that are difficult to emulsify and have excellent storage stability. Effect

Active Publication Date: 2021-01-19
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses a large amount of toxic organic solvents, causing harm to the environment and staff, and is not a preferred preparation method

Method used

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  • Lutein/lutein ester microparticles and preparation method thereof

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[0016] The invention provides a kind of lutein / lutein ester microparticles and its preparation method. The method is prepared by preparing a raw material mixture containing lutein and / or lutein ester, wall material and co-emulsifier under low temperature conditions. A nanoemulsion with a particle size of no more than 1 micron is sprayed onto sucrose starch particles.

[0017] In the above technical solution, the low temperature condition can be limited to 10-35°C, preferably 25-30°C according to the common understanding in the art. The preparation of the nanoemulsion can also adopt methods commonly used in the prior art, and these methods can be exemplified but not limited to colloid mill dispersion and high-pressure homogenization. The sucrose starch granules are used as a carrier and can be prepared according to the records of the prior art according to the requirements of the product. In the present invention, the sucrose starch granules prepared by using a mixture of star...

Embodiment 1

[0031]Add 170g of lutein ester crystals, 20g of ascorbyl palmitate, 30g of sodium ascorbate, and 30g of vitamin E into 200ml of water, and disperse at high speed for 1 hour at 15°C; make 100g of hydroxypropylmethylcellulose into a 6.25% aqueous solution at room temperature, and stir to dissolve Finally, pour it into the high-speed dispersed lutein ester aqueous solution, keep the temperature of the emulsion at 25°C, and stir for 30 minutes; disperse at high speed through a colloid mill to obtain a lutein ester emulsion, and the particle size of the emulsion is D99 / D90 / D50=57.21 / 47.65 / 27.52 μm, spray the emulsion on the surface of 680 g of sucrose-starch granules with a size of 150-200 μm in the form of spray coating. After the lutein ester emulsion wraps the sucrose-starch granules layer by layer, the formed lutein ester microparticle A (theoretical content is 12.2%) has a content of 12.1%, a surface pigment content of 9.8%, and a bulk density of 0.60 g / ml. Its pigment retent...

Embodiment 2

[0033] Dissolve 16.7g of pullulan in 200ml of water, add 90g of lutein crystals, 20g of ascorbyl palmitate, 30g of ascorbyl stearate, 30g of dl-α-tocopherol, and disperse at a high speed for 1 hour at 25°C; 133.3 g of hydroxypropyl methylcellulose was configured into a 6.25% aqueous solution, stirred and dissolved, poured into a high-speed dispersed lutein aqueous solution, and kept the temperature of the emulsion at 25°C, and stirred for 30 minutes; the lutein emulsion was obtained by high-speed dispersion through a colloid mill. The particle size of the emulsion is D99 / D90 / D50=0.90 / 0.75 / 0.21 μm, and the emulsion is sprayed on the surface of 680 g of starch-sugar particles with a size of 180-300 μm in the form of spray coating. After the lutein emulsion wraps the sucrose starch granules layer by layer, lutein particles B (theoretical content is 6.3%) are formed, the content is 6.4%, the surface pigment content is 0.1%, and the bulk density is 0.75g / ml. Its pigment retention r...

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Abstract

The invention discloses lutein / lutein ester microparticles and a preparation method thereof. The lutein / lutein ester microparticles are prepared by preparing a nano-emulsion which is no more than 1mmin grain size from a raw material mixture of lutein and / or lutein ester, a wall material and a co-emulsifier under a low-temperature condition, and spraying the nano-emulsion onto sucrose-starch particles, wherein the wall material is a cellulose derivative. With the application of the preparation method, inherent defects of a lutein / lutein ester raw material in a preparing process can be overcome, and problems caused by melting crystals at high temperature or by a solvent can be avoided; and by selecting and combining the cellulose derivative and the co-emulsifier, a problem that the lutein / lutein ester is difficult to emulsify can be effectively solved. Therefore, in the obtained lutein / lutein ester microparticle product, the content of active components can reach 25% and the lutein / lutein ester microparticle product is quite excellent in preservation stability. The microparticle product, as required, can be applied to the preparation of foods, medicines, health-care products, functional foods and the like.

Description

technical field [0001] The invention relates to a class of carotenoid preparations and a preparation method. Background technique [0002] Carotenoids have strong anti-oxidation and other functions, and the market demand continues to increase. Among them, lutein, lutein ester and zeaxanthin derived from marigolds have unique eye protection functions and can prevent ultraviolet rays from being damaged. At the same time, it can be used as a strong oxidant to inhibit the activity of active oxygen free radicals, and play a role in skin care, heart protection and immunity enhancement. The announcement of the Ministry of Health of my country has established and approved lutein ester and zeaxanthin as functional new resource food. [0003] At present, lutein and its esters and zeaxanthin are mainly used in functional foods and dietary supplements for eye protection, mainly in the form of soft capsules and microcapsule powders. In recent years, convenient tablet products have bee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/047A61K31/23A61K8/37A61K8/34A61K8/02A23L33/105A23P20/18A23P10/30A61P39/06A61Q19/08
CPCA23V2002/00A61K8/0245A61K8/345A61K8/37A61K9/167A61K31/047A61K31/23A61Q19/08A23L33/105A23P10/30A23P20/18A61P39/06A23V2250/211
Inventor 李倩陈剑彬陈碧聪吴文忠
Owner INNOBIO CORP LTD
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