Flexible composite sustained release oral capsule

Abstract

The invention discloses a flexible composite sustained release oral capsule. The oral capsule consists of an oral capsule body and a drug-containing composite fibrous membrane which is placed into theoral capsule body in a folded mode, wherein the drug-containing composite fibrous membrane is of a meshed structure which comprises at least two blocks which are different in specification; and the different specifications refer to at least two different fibrous materials and / or mesh sizes. Various drugs can be covered by the fibrous materials, and the fibrous materials can be folded and nested into the soft capsule, so that adaptability of oral administration is enhanced. When the capsule is orally taken and enters a stomach, the outer layer of the capsule is dissolved and the folded fibrousmembrane can be flexibly expanded into a film, so that release combination of various fibrous materials and various drugs can be achieved, and retention time and treatment efficiency of drug carriersin stomach and intestine can be improved; and the drugs can be released on the upper sides of the stomach and intestine from a fibrous structure area and can finally get completely degraded, so thata problem of frequent administration every day can be improved and treatment efficacy and safety of the composite medicine (the composite capsule) can be enhanced.

Description

technical field

[0001] The invention belongs to the field of drug carrier preparation, in particular to a flexible composite slow-release oral capsule. Background technique

[0002] Personalized drug customization for different patients has become an increasingly popular field in recent years. The currently used oral medicaments are mainly mass-produced tablets or capsules. Among them, oral capsules are mainly filled with a certain dose of medicine in the capsule. Because of its shape and characteristics, it is easier for patients to swallow and can mask the bad smell of the medicine. However, each individual has a certain difference in drug response. These mass-produced drugs are only suitable for a certain range of patients. For some patients, the dose may be too large or too small, and the duration of action is too long or too short.

[0003] In addition, currently used oral agents are mostly single-drug tablets, such as aspirin tablets for antipyretic and analgesic, pra...

Examples

Embodiment 1

[0045] Write the printing program according to Figure 3(a). The composite fiber membrane is composed of block 1 and block 2 with different grid sizes. ×300μm grid composition. The solute accounts for 40wt% of the electrospinning solution, the solute is polyacrylic acid resin, the solvent is mixed with ethanol and dimethylformamide at a volume ratio of 1:1, and is configured into a polymer solution by magnetic stirring, and the drug concentration is set to 2 %, according to the set concentration, dissolve aspirin into the above polyacrylic acid resin solution, and finally obtain the drug-containing polymer solution as the printing material of block 1; the solute accounts for 22wt% of the electrospinning solution, the solute is cellulose acetate, and the solvent is made of acetone It is mixed with dimethylacetamide at a volume ratio of 1:1, configured into a polymer solution by magnetic stirring, and the drug concentration is set to 1.1%, and pravastatin is dissolved into the abov...

Embodiment 2

[0047] Write the printing program according to Figure 3(b). The composite fiber membrane is composed of block 1 and block 2 with different grid spacing. ×450μm grid composition. The solute accounts for 12% of the electrospinning solution. The solute is composed of polyvinylpyrrolidone and polyoxyethylene in a mass ratio of 1:1, and the solvent is composed of ethanol and water in a volume ratio of 4:1. Through magnetic stirring, the configuration Form a polymer solution, set the drug concentration to 3%, dissolve tetracycline into the above-mentioned zein solution according to the set concentration, and finally obtain a drug-containing polymer solution as the printing material of block 1; the solute accounts for 9wt% of the electrospinning solution, The solute is formed by mixing polylactic acid and polyethylene glycol at a mass ratio of 7:3, and the solvent is formed by mixing dichloromethane and acetone at a volume ratio of 1:1, and is configured into a polymer solution by ma...

Embodiment 3

[0049] Write the printing program according to Figure 3(c). The composite fiber membrane is composed of block 1, block 2 and block 3 with different grid spacings. Block 1 is composed of grids with a size of 80 μm×80 μm. Block 2 Consisting of a grid of size 240 μm × 240 μm, block 3 consists of a grid of size 500 μm × 500 μm. The solute accounts for 18wt% of the electrospinning solution, and the solute is ethyl cellulose, and the solvent is mixed with tetrahydrofuran and dimethylacetamide at a volume ratio of 2:3, and is configured into a polymer solution by magnetic stirring, and the drug concentration is set to 0.5%, according to the set concentration, dissolve captopril into the above-mentioned ethyl cellulose solution, and finally obtain the drug-containing polymer solution as the printing material of block 1; the solute accounts for 26wt% of the electrospinning solution, and the solute is polyhexyl The lactone, the solvent is acetic acid, is configured into a polymer soluti...

technical field

[0001] The invention belongs to the field of drug carrier preparation, in particular to a flexible composite slow-release oral capsule. Background technique

[0002] Personalized drug customization for different patients has become an increasingly popular field in recent years. The currently used oral medicaments are mainly mass-produced tablets or capsules. Among them, oral capsules are mainly filled with a certain dose of medicine in the capsule. Because of its shape and characteristics, it is easier for patients to swallow and can mask the bad smell of the medicine. However, each individual has a certain difference in drug response. These mass-produced drugs are only suitable for a certain range of patients. For some patients, the dose may be too large or too small, and the duration of action is too long or too short.

[0003] In addition, currently used oral agents are mostly single-drug tablets, such as aspirin tablets for antipyretic and analgesic, pra...

Examples

Embodiment 1

[0045] Write the printing program according to Figure 3(a). The composite fiber membrane is composed of block 1 and block 2 with different grid sizes. ×300μm grid composition. The solute accounts for 40wt% of the electrospinning solution, the solute is polyacrylic acid resin, the solvent is mixed with ethanol and dimethylformamide at a volume ratio of 1:1, and is configured into a polymer solution by magnetic stirring, and the drug concentration is set to 2 %, according to the set concentration, dissolve aspirin into the above polyacrylic acid resin solution, and finally obtain the drug-containing polymer solution as the printing material of block 1; the solute accounts for 22wt% of the electrospinning solution, the solute is cellulose acetate, and the solvent is made of acetone It is mixed with dimethylacetamide at a volume ratio of 1:1, configured into a polymer solution by magnetic stirring, and the drug concentration is set to 1.1%, and pravastatin is dissolved into the abov...

Embodiment 2

[0047] Write the printing program according to Figure 3(b). The composite fiber membrane is composed of block 1 and block 2 with different grid spacing. ×450μm grid composition. The solute accounts for 12% of the electrospinning solution. The solute is composed of polyvinylpyrrolidone and polyoxyethylene in a mass ratio of 1:1, and the solvent is composed of ethanol and water in a volume ratio of 4:1. Through magnetic stirring, the configuration Form a polymer solution, set the drug concentration to 3%, dissolve tetracycline into the above-mentioned zein solution according to the set concentration, and finally obtain a drug-containing polymer solution as the printing material of block 1; the solute accounts for 9wt% of the electrospinning solution, The solute is formed by mixing polylactic acid and polyethylene glycol at a mass ratio of 7:3, and the solvent is formed by mixing dichloromethane and acetone at a volume ratio of 1:1, and is configured into a polymer solution by ma...

Embodiment 3

[0049] Write the printing program according to Figure 3(c). The composite fiber membrane is composed of block 1, block 2 and block 3 with different grid spacings. Block 1 is composed of grids with a size of 80 μm×80 μm. Block 2 Consisting of a grid of size 240 μm × 240 μm, block 3 consists of a grid of size 500 μm × 500 μm. The solute accounts for 18wt% of the electrospinning solution, and the solute is ethyl cellulose, and the solvent is mixed with tetrahydrofuran and dimethylacetamide at a volume ratio of 2:3, and is configured into a polymer solution by magnetic stirring, and the drug concentration is set to 0.5%, according to the set concentration, dissolve captopril into the above-mentioned ethyl cellulose solution, and finally obtain the drug-containing polymer solution as the printing material of block 1; the solute accounts for 26wt% of the electrospinning solution, and the solute is polyhexyl The lactone, the solvent is acetic acid, is configured into a polymer soluti...

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