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Niclosamide ethanolamine dry flowable and preparation method thereof

The technology of spirulina ethanolamine salt and dry suspending agent is applied in the field of pesticides, which can solve the problems affecting the spray drying process and the high viscosity of the slurry, and achieve the effects of low storage and transportation cost, good dispersibility and good sieving performance.

Active Publication Date: 2018-11-02
QINGDAO RAINBOW CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, when preparing high-content dry suspension concentrate of spiroxamine ethanolamine salt, the viscosity of the obtained slurry is too high during the wet pulverization process of spiroxamine ethanolamine salt and additives, which affects the subsequent spray drying process

Method used

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  • Niclosamide ethanolamine dry flowable and preparation method thereof
  • Niclosamide ethanolamine dry flowable and preparation method thereof
  • Niclosamide ethanolamine dry flowable and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 186

[0032] Embodiment 1 86% spiroxamine ethanolamine salt dry suspension concentrate

[0033] The formula is: 86% ethanolamine salt of spiroxamine, 3.2% hyperbranched polyamide ester as a dispersant, 1.6% fatty alcohol polyoxyethylene ether sulfate, 3.2% sodium lignosulfonate, and 1 sodium lauryl sulfate as a wetting agent %, sodium alkylnaphthalene sulfonate 2%, disintegrant ammonium sulfate 1%, diammonium hydrogen phosphate 1%, defoamer organosiloxane 0.5%, filler kaolin to make up 100%.

[0034] The preparation method is as follows:

[0035] 1. Mix the original medicine of spiroxamine ethanolamine salt, dispersant, wetting agent, disintegrant, defoamer, filler and water to obtain a slurry, and the amount of water is 45-50% of the total mass of each component.

[0036]2. Grind the uniformly mixed slurry with a sand mill until the particle size D90 is 3-5μm, then pump the suspoemulsion slurry into a pressure spray dryer for drying and granulation. The spray pressure is controlle...

Embodiment 2

[0037] Embodiment 2 80% dry suspension concentrate of spiroxamine ethanolamine salt

[0038] The formula is: spiroxamine ethanolamine salt 80%, dispersant hyperbranched polyamide ester 3.2%, fatty alcohol polyoxyethylene ether sulfate 1.6%, sodium lignosulfonate 3.2%, wetting agent sodium lauryl sulfate 1 %, sodium alkylnaphthalene sulfonate 2%, disintegrant ammonium sulfate 1%, diammonium hydrogen phosphate 1%, defoamer organosiloxane 0.5%, filler kaolin to make up 100%.

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0040] Example 3 70% spiroxamine ethanolamine salt dry suspension

[0041] The formula is: 70% ethanolamine salt of spiroxamine, 1.5% hyperbranched polyamide ester as a dispersant, 1.5% fatty alcohol polyoxyethylene ether sulfate, 3% sodium lignosulfonate, and 1.2% sodium lauryl sulfate as a wetting agent %, sodium alkylnaphthalene sulfonate 4.8%, disintegrant ammonium sulfate 1%, diammonium hydrogen phosphate 1%, defoamer organosiloxane 1%, filler kaolin supplement 100%.

[0042] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a niclosamide ethanolamine dry flowable and a preparation method thereof. The dry flowable comprises an effective component and additives, wherein the effective component is niclosamide ethanolamine; the additives include a dispersing agent, a wetting agent, a disintegrating agent, a defoaming agent and a filler. According to the dry flowable, the effective component content is high and up to 90%; the dry flowable is small in particle size, outstanding in performance, high in storing stability and low in storing and carrying cost, has high activity to mollusc pests suchas ampullaria gigas, oncomelania and snail, and is fast to disinfect insects, long-lasting in effect, and convenient to use.

Description

technical field [0001] The invention relates to a dry suspension concentrate of spiroxamine ethanolamine salt and a preparation method of the dry suspension concentrate, belonging to the technical field of pesticides. Background technique [0002] Spirocidal is the only molluscicide recommended by the World Health Organization for on-site use in my country. Because it is difficult to dissolve in water and affects the molluscicidal effect, it is generally made into spirulina ethanolamine salt. Niclosamideethanolamine salt is an amide compound, its chemical name is N-(2-chloro-4-nitrophenyl)-2-hydroxy-5-chlorobenzoylethanolamine, and its CAS is 1420-04- 8. The pure product of spiroxamine ethanolamine salt is yellow crystal, which is the most widely used molluscicide at present. , snail eggs, schistosomiasis cercariae and hairy butterflies, etc. have a strong killing effect, rapid action and long-lasting drug effect. Because of its strong molluscicidal effect and low toxicit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N25/14A01P9/00
CPCA01N25/14A01N37/40Y02A50/30
Inventor 孙国庆袁良国侯永生路雪林
Owner QINGDAO RAINBOW CHEM CO LTD
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