Nanometer hydroxyapatite powder preparation method

A nano-hydroxyapatite, powder technology, applied in chemical instruments and methods, phosphorus compounds, chemical/physical/physical-chemical processes of applying energy, etc. problems such as group agglomeration, to achieve the effect of reducing the preparation cost, good crystallinity, and no agglomeration

Inactive Publication Date: 2004-11-10
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The sol-gel method can also obtain nano-scale hydroxyapatite powder, for example, Bezzi G et al. 3 ) 2 4H 2 O, P 2 o 5 and isopropanol as raw materials, through a series of sol-gel processes, and finally synthesized hydroxyapatite powder under the calcination conditions of 500-800 ° C [Bezzi G, Celotti G, Landi E, La Torretta TMG, Sopyan I, Tampieri A.A novelsol-gel technique for hydroxyapatite preparation. Mater Chemis and Phys 2003; 78:816-24], this method is more complicated, and the particle size of the powder is closely related to the heat treatment process, and it is not easy to obtain Hydroxyapatite, if the temperature is too high, the obtained powder will be seriously agglomerated, which will affect the performance

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  • Nanometer hydroxyapatite powder preparation method

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Experimental program
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Effect test

Embodiment 1

[0008] Embodiment 1: first calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O and diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 , mix according to the molar ratio of Ca:P=1.67:1, add distilled water to dissolve, and make the Ca in the solution 2+ The concentration of ions is 0.05mol / L; add urea powder in the solution according to the total mass of calcium nitrate tetrahydrate and diammonium hydrogen phosphate: urea=1:5, and stir evenly; under magnetic stirring, the multi-frequency acoustic chemical generator Put the generating head into the above solution, and carry out sonochemical synthesis for 3 hours at 80°C with an ultrasonic frequency of 35KHz; filter and wash the suspension, first wash 2 times with distilled water, then wash 3 times with absolute ethanol, and filter out The materials were put into a vacuum drying oven and dried at 80°C to obtain nano-hydroxyapatite powder.

[0009] The crystal structure and particle size of the obtained powder were analyzed by the Ja...

Embodiment 2

[0010] Embodiment 2: first calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O and diammonium hydrogen phosphate (NH 4 ) 2 HPO 4, mix according to the molar ratio of Ca:P=2:1, add distilled water to dissolve, and make the Ca in the solution 2+ The concentration of ions is 0.01mol / L; add urea powder in the solution according to the total mass of calcium nitrate tetrahydrate and diammonium hydrogen phosphate: urea=1:6, and stir evenly; under magnetic stirring, the multi-frequency acoustic chemical generator Put the generating head into the above solution, and carry out sonochemical synthesis for 3 hours at 80°C with an ultrasonic frequency of 25KHz; filter and wash the suspension, first wash 2 times with distilled water, then wash 3 times with absolute ethanol, and filter out The materials were put into a vacuum drying oven and dried at 90°C to obtain nano-hydroxyapatite powder.

[0011] The crystal structure and particle size of the obtained powder were analyzed by the Japane...

Embodiment 3

[0012] Embodiment 3: first calcium nitrate tetrahydrate Ca(NO 3 ) 2 4H 2 O and diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 , mix according to the molar ratio of Ca:P=2.5:1, add distilled water to dissolve, and make the Ca in the solution 2+ The concentration of ions is 0.01mol / L; add urea powder in the solution according to the total mass of calcium nitrate tetrahydrate and diammonium hydrogen phosphate: urea=1:7, and stir evenly; under magnetic stirring, the multi-frequency acoustic chemical generator Put the generating head into the above solution, and carry out sonochemical synthesis for 3 hours at 80°C with an ultrasonic frequency of 35KHz; filter and wash the suspension, first wash 2 times with distilled water, then wash 3 times with absolute ethanol, and filter out Put the material into a vacuum drying oven and dry it at 100°C to obtain nano-hydroxyapatite powder.

[0013] The crystal structure and particle size of the obtained powder were analyzed by the Japanes...

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Abstract

A process for preparing nano hydroxyapatite powder comprises the steps of, mixing Ca(NO3)-2-4H20 and NH4-2HPO-4 according to the mol ratio of Ca:P = 1.67-2.5:1, dissolving by charging distilled water, making the concentration of the Ca2++ ion to be 0.01-0.1 mol / L, charging aquadrate powder into the solution according the ratio of Ca(NO3)-2-4H2O : NH4-2HPO-4 = 1:5-12, conducting sound chemo synthesis through multiple frequency phonochemical generator, filtrating and washing the suspending liquid, placing the filtered material into vacuum drying oven for drying at the temperature of 80-100 deg. C, thus the nano hydroxyapatite powder can be obtained.

Description

technical field [0001] The invention relates to a preparation method of hydroxyapatite powder, in particular to a preparation method of nano-nano hydroxyapatite powder. Background technique [0002] Hydroxyapatite has good chemical stability and biocompatibility, is non-biotoxic, and its cross-sectional biological activity is superior to various medical titanium alloys, silicone rubber and carbon materials for bone grafting. It can be widely used as a material for biological hard tissues. Repair and replace materials. Hydroxyapatite powder can be used as a filling material for bone damage, and can also be used to prepare hydroxyapatite ceramics. At the same time, applying nano-hydroxyapatite to toothpaste will help prevent dental caries and periodontal disease. Prevention and treatment of major oral diseases. At present, the synthesis methods of p-hydroxyapatite powder at home and abroad mainly include: precipitation method, hydrothermal synthesis method, sol-gel method, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/10C01B25/32
Inventor 黄剑锋曹丽云
Owner SHAANXI UNIV OF SCI & TECH
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