Tubular bacterial nanocellulose material and preparation method and application thereof

Abstract

The invention relates to a tubular bacterial nanocellulose material and a preparation method and application thereof. Fibers on the inner surface of the tubular bacterial nanocellulose material are loose, and fibers on the outer surface of the tubular bacterial nanocellulose material are dense. The preparation method comprises the following steps of fermentation broth preparation, device assemblyand tubular bacterial nanocellulose material preparation. The tubular bacterial nanocellulose material is applied to artificial blood vessels, artificial nerve conduits or artificial ureters. The fibers on the inner surface of the prepared tubular BNC (bacterial nanocellulose) material are loose, the fibers on the outer surface of the prepared tubular BNC material are dense, and the prepared tubular BNC material is a material different from previously reported tubular BNC material in structure, and is a biomaterial with a great application potential; the tubular bacterial nanocellulose material is an excellent substrate material for preparing a BNC composite pipe; and the blood compatibility of the inner surface of the tubular bacterial nanocellulose material is higher than that of reported products obtained by several other reactors.

Description

technical field [0001] The invention belongs to the field of cellulose material and its preparation method and application, in particular to a tubular bacterial nanocellulose material and its preparation method and application. Background technique [0002] Bacterial nanocellulose (BNC) is a kind of cellulose produced by bacteria, which has the same chemical composition as plant cellulose, but has high chemical purity, high water content, unique three-dimensional network structure, and good biocompatibility. It is widely used in food industry, cosmetics industry, electronics industry, biomedical materials and other fields. [0003] The structure and properties of BNC can be regulated by controlling the culture conditions. According to different culture methods, BNCs of different shapes can be prepared, including membranes, blocks, tubes, microspheres, etc. Tubular BNCs can be prepared by designing special devices. According to reports, there are currently many different ty...

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Problems solved by technology

The length of the BNC tube obtained by this method is controllable, but there is radial delamination

The third device is composed of an inner silicone tube and an outer glass tube. The fermentation broth is inoculated in the inner cavity of the inner silicone tube and the outer glass tube, and it is placed in an air or oxygen environment, and a BNC tube can be formed in the cavity. The formation of the BNC tube prepared by the device and method is similar to the second method, and there is also delamination

Although the dense inner surface of the BNC tube is conducive to the adhesion and spreading of cells, at the same time, platelets are also easier to adhere to, which promotes blood coagulation to a certain extent; The inner wall of the lumen introduces other polymers, resulting in uneven structure of the synthesized composite material

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