Preparation and application of a cell membrane biomimetic lipoprotein targeting nano drug delivery system

A nano-drug delivery system and cell membrane technology, which is applied in the preparation and application of cell membrane biomimetic lipoprotein-targeted nano-drug delivery system, can solve limitations and other problems, and achieve the effects of increasing directional accumulation, increasing therapeutic effect, and improving bioavailability
CN108837154BActive Publication Date: 2021-05-07CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2021-05-07

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Abstract

The invention belongs to the field of pharmaceutical preparations, and relates to the preparation and application of a cell membrane biomimetic lipoprotein targeting nano drug delivery system. This patent uses recombinant high-density lipoprotein (rHDL) in the lipoprotein family to embed anti-obesity drugs to form a drug-loaded core, and P3 peptide to modify cell membranes to form a bionic shell, and to construct a biomimetic targeting nanoparticle for obesity treatment. The characteristics of the particles are as follows: (1) The cell membrane bionic shell modified by P3 peptide has good biocompatibility and adipose tissue targeting, which can reduce the opsonization and phagocytosis of nanoparticles by the immune system, prolong the circulation time of drugs in the body, and increase the concentration of drugs. Accumulation in adipose tissue; (2) rHDL core drug carrier has high safety and good carrying capacity, can load fat-soluble drugs through core embedding, and can be completely biodegraded without triggering immune response; (3) Anti-obesity drugs can stimulate adipose tissue angiogenesis and increase browning of white adipose tissue, and the mechanism can be used synergistically to treat obesity.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to the preparation and application of a cell membrane biomimetic lipoprotein targeting nano drug delivery system. Background technique

[0002] Obesity is caused by the excessive accumulation of fat in the body due to the imbalance between energy absorption and energy consumption. It is a symptom of metabolic syndrome, type II diabetes (T 2 DM), cardiovascular disease, cancer and other chronic diseases, seriously affecting human life expectancy. At present, in addition to diet and exercise, clinical treatments for weight loss can be divided into two types, one is surgical treatment, such as liposuction and gastric bypass surgery, and the other is drug treatment, such as orlistat , Lorcaserin hydrochloride, etc. However, both treatment methods have side effects in varying degrees: surgical treatment has poor patient compliance, while drug treatment, such as orlistat, has se...

Claims

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