Pharmaceutical composition of multiple trace elements VII and application thereof

Abstract

The invention provides application of medicines for preparing injection with multiple trace elements VII for preventing or treating deficiency of multiple trace elements, including deficiency of zinc,manganese, copper, chromium, selenium, iodine and molybdenum and syndromes of human and mammals, so that the adverse response of the injection is reduced, and the corresponding medicines have highersecurity, treatment compliance and the like in a clinical treatment process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and in particular provides a pharmaceutical composition for various trace element injections for preventing or treating zinc, manganese, chromium, copper, selenium, iodine, molybdenum deficiency and syndromes thereof, and its preparation and application . Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with thiol, block the combination of thiol and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit the peroxidation of fat, stabilize the cell membrane and make it more resistant to free radical attacks, Therefore, zinc is of great significance not only to cell grow...

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Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism

Although the physiological pH of the human body generally reaches about 7.4, the pH value in the preparation in the prior art is maintained at a very low level, and the general pH value is between 1.8 and 3.0 to prevent quality problems in the injection. Drug preparation and clinical intravenous infusion bring a certain degree of safety hazards and some adverse reactions, including vascular irritation or phlebitis, local necrosis, poor patient tolerance or clinical accidents, etc., especially once the injection is in the preparation process or Particles appear during the infusion process, which is prone to accidental fatal dangers during the infusion process of patients. These particles may be invisible to the naked eye in the case of insufficient background, but these have been ignored for a long time

[0010] The multiple trace element injections (Trace Elements Injection in the U.S.) of the prior art also exist in some cases and are not suitable for patients with acidosis and renal insufficiency. Medication may bring about adverse consequences; {References: Document 1, Yin Peida, Pathogenesis of Distal Renal Tubular Acidosis, Foreign Medicine (Internal Medicine), Issue 12, 1982; Document 2, Zhou Lei, et al., 12 cases Misdiagnosis and nursing care of patients with renal tubular acidosis, Chinese Journal of Practical Nursing, Issue 17, 2005}

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