A catalyst for regulating side arm effect, its preparation method and its application
A catalyst and reaction technology, applied in the field of catalysts regulated by the sidearm effect, can solve problems such as low activity, low copolymer molecular weight, low insertion ratio, etc.
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[0064] The present invention provides a kind of preparation method of the catalyst described in above-mentioned technical scheme, comprises the following steps:
[0065] reacting a compound having a structure shown in formula (II) with a precursor compound in an organic solvent to obtain a catalyst having a structure shown in formula (I);
[0066]
[0067] The precursor compound is selected from trans-[(Y) 2 Ni(Cl)R 7 ] nickel precursor compound and / or (tmeda)Pd(R 6 ) 2 The palladium precursor compound, tmeda is tetramethylethylenediamine.
[0068] In the present invention, the organic solvent is preferably selected from tetrahydrofuran, petroleum ether, toluene, benzene, methylene chloride, tetrachloromethane, ether, 1,4-dioxane and 1,2-dichloroethane One or more; more preferably selected from 1,4-dioxane.
[0069] In the present invention, the trans-[(Y) 2 Ni(Cl)R 7 ] The nickel precursor compound is preferably trans-[(PPh 3 ) 2 Ni(Cl)Ph], Ph is an aryl group.
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Embodiment 1
[0098] Embodiment 1: the preparation of 2-((2-methoxyphenyl) (phenyl) phosphino) benzenesulfonic acid
[0099]
[0100]At 0°C, n-butyllithium (concentration of 2.5 moles per liter, 8 milliliters, 20 millimoles) was slowly added dropwise to a mixture of benzenesulfonic acid (1.58 grams, 10 millimoles) dissolved in 25 milliliters of tetrahydrofuran, reaction 1 Hour. Then, a mixed solution of phenylphosphine dichloride (1.35 ml, 10 mmol) dissolved in 25 ml of tetrahydrofuran was added thereto, and reacted at room temperature for 2 hours to obtain a mixed solution A. 2-Bromoanisole (1.86 g, 10 mmol) was dissolved in 20 ml of tetrahydrofuran under nitrogen protection and cooled to minus 78°C. n-Butyllithium (concentration: 2.5 moles per liter, 4 milliliters, 10 millimoles) was added slowly, and reacted at minus 78° C. for 1 hour. The obtained lithium salt was added to the mixed solution A at minus 78°C, and reacted at room temperature for 24 hours. The solvent was spin-dried,...
Embodiment 2
[0101] Embodiment 2: the preparation of 2-((2-phenoxyphenyl) (phenyl) phosphino) benzenesulfonic acid
[0102]
[0103] The synthesis procedure is the same as in Example 1, except that 1-bromo-2-phenoxybenzene (2.49 grams, 10 mmol) was added to obtain a white solid (2.8 g, 65% yield), i.e. 2-( (2-phenoxyphenyl)(phenyl)phosphino)benzenesulfonic acid. 1 H NMR (400MHz, CDCl3) δ8.39 (dd, J = 7.2, 5.1Hz, 1H), 7.84-7.71 (m, 2H), 7.70-7.57 (m, 5H), 7.49 (m, 1H), 7.41- 7.26(m,4H),7.26-7.14(m,2H),6.96-6.82(m,3H).13C NMR(100MHz,CDCl3)δ160.27(d,J=1.8Hz),153.93(s),152.79 (d, J=9.0Hz), 136.71(d, J=2.0Hz), 135.25(s), 135.17(s), 134.75(d, J=12.1Hz), 134.37(d, J=2.9Hz), 133.15 (d, J=11.3Hz), 130.21(s), 130.04(d, J=13.3Hz), 129.84(d, J=13.2Hz), 129.31(d, J=9.3Hz), 125.72(s), 123.92 (d, J=13.4Hz), 120.27(s), 119.01(d, J=88.5Hz), 116.67(d, J=6.2Hz), 112.38(d, J=97.3Hz), 108.48(d, J= 97.5Hz).31P NMR (162MHz, CDCl3) δ-1.14. ESI-MS (m / z): [M-H] - Calculated: C24H18O4PS, 433.0658; Found: 433...
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