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Ferrous glycine enteric-soluble sustained-release pellets with coated structures, and preparation method of ferrous glycine enteric-soluble sustained-release pellets

A technology of ferrous glycinate and ferrous glycinate, which is applied in the field of feed preparation, can solve the problems of reducing the absorption of ferrous glycinate, being oxidized and deteriorating, and the properties of ferrous iron are unstable, so as to avoid the interference of oxygen and water and overcome the properties of ferrous glycine. Unstable, bioavailability-enhancing effect

Pending Publication Date: 2018-12-18
ZHONGKAI UNIV OF AGRI & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is very unfavorable for its unstable ferrous iron. Ferrous iron is unstable in nature and is easily oxidized to ferric ions. Therefore, ferrous glycinate in iron supplements is often easily affected by oxygen and moisture in the air, resulting in The disadvantages of easy moisture absorption and oxidative deterioration greatly increase the difficulty of storage and transportation; moreover, the solid powder is used as an iron supplement. In the process of iron supplementation to livestock, since the pH of the stomach environment is about 1, the acidity is relatively high. Strong, ferrous glycinate is often affected by the strong acidic environment of gastric juice, and the structure of ferrous glycinate is destroyed, which reduces the absorption of ferrous glycinate by subsequent intestinal juice, greatly reduces the bioavailability of iron supplements to livestock iron, and increases Difficulty taking iron supplements

Method used

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  • Ferrous glycine enteric-soluble sustained-release pellets with coated structures, and preparation method of ferrous glycine enteric-soluble sustained-release pellets
  • Ferrous glycine enteric-soluble sustained-release pellets with coated structures, and preparation method of ferrous glycine enteric-soluble sustained-release pellets
  • Ferrous glycine enteric-soluble sustained-release pellets with coated structures, and preparation method of ferrous glycine enteric-soluble sustained-release pellets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1-a preparation method of ferrous glycinate enteric-coated sustained-release pellets with a coating structure, comprising the following steps:

[0036] (1) After preheating the coating device, put the sucrose ball core into the coating device, and start the exhaust and dust collection device;

[0037] (2) Preheating the sucrose core with hot air, so that the sucrose core is evenly heated, and absorbs the fine powder adsorbed on the sucrose core;

[0038] (3) Open the compression pump, and adjust the fan frequency to be 18 and the liquid supply speed to be 12, spray the prepared drug-loaded coating solution, isolation coating solution, and enteric coating solution to the surface of the sucrose pellet core successively, and The coating liquid temperature of each layer is 45 ℃;

[0039] Wherein, the formulation components of the drug-loaded coating solution include a hydroxypropylmethylcellulose solution with a concentration of 0.035g / ml and a ferrous glycinate...

Embodiment 2

[0041] Embodiment 2-a preparation method of ferrous glycinate enteric-coated sustained-release pellets with a coating structure, comprising the following steps:

[0042] (1) After preheating the coating device, put the sucrose ball core into the coating device, and start the exhaust and dust collection device;

[0043] (2) Preheating the sucrose core with hot air, so that the sucrose core is evenly heated, and absorbs the fine powder adsorbed on the sucrose core;

[0044] (3) Open the compression pump, and adjust the fan frequency to be 17 and the liquid supply speed to be 8, spray the prepared drug-loaded coating solution, isolation coating solution, and enteric coating solution to the surface of the sucrose ball core successively, and The coating liquid temperature of each layer is 42 ℃;

[0045] Wherein the formulation components of the drug-loaded coating solution include a hydroxypropylmethylcellulose solution with a concentration of 0.035g / ml and a ferrous glycinate sol...

Embodiment 3

[0048] Embodiment 3-a preparation method of ferrous glycinate enteric-coated sustained-release pellets with a coating structure, comprising the following steps:

[0049] (1) After preheating the coating device, put the sucrose ball core into the coating device, and start the exhaust and dust collection device;

[0050] (2) Preheating the sucrose core with hot air, so that the sucrose core is evenly heated, and absorbs the fine powder adsorbed on the sucrose core;

[0051] (3) Open the compression pump, and adjust the fan frequency to be 17 and the liquid supply speed to be 10, spray the prepared drug-loaded coating solution, isolation coating solution, and enteric coating solution to the surface of the sucrose ball core successively, and The coating liquid temperature of each layer is 44 ℃;

[0052] Wherein, the formulation components of the drug-loaded coating solution include a hydroxypropylmethylcellulose solution with a concentration of 0.035g / ml and a ferrous glycinate s...

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Abstract

The invention relates to ferrous glycine enteric-soluble sustained-release pellets with coated structures, and a preparation method of the ferrous glycine enteric-soluble sustained-release pellets. The sustained-release pellets separately comprise a sucrose pellet core, a medicine-loading coating layer and an enteric-soluble coating layer; the medicine-loading coating layers cover the exteriors ofthe sucrose pellet cores; the enteric-soluble coating layers cover the exteriors of the medicine-loading coating layers; the medicine-loading coating layers are prepared from the following effectivecomponents: hydroxypropyl methyl cellulose and ferrous glycine; the enteric-soluble coating layers are prepared from the following effective components: polyacrylic resin A, polyacrylic resin B, butylphthalate, talc powder and ethanol. A feed additive is combined with a dosage form for the first time, and similar dosage form modification is performed on an iron supplement agent, so that the defects that the iron supplement agent is not stable in properties, easy in moisture absorption and easy to oxidize are overcome; after an enteric coating way is adopted, the storage stability, transport stability and stability in gastric juice of the sustained-release pellets are greatly improved, and the bioavailability of livestock iron supplement is improved.

Description

technical field [0001] The invention relates to the technical field of feed preparation, in particular to ferrous glycinate enteric-coated slow-release pellets with a coating structure and a preparation method. Background technique [0002] Existing iron supplements are usually chemically synthesized by ferrous glycinate and obtained as dark green solid powder after drying, and the preparation process is simple. However, it is very unfavorable for its unstable ferrous iron. Ferrous iron is unstable in nature and is easily oxidized to ferric ions. Therefore, ferrous glycinate in iron supplements is often easily affected by oxygen and moisture in the air, resulting in The disadvantages of easy moisture absorption and oxidative deterioration greatly increase the difficulty of storage and transportation; moreover, the solid powder is used as an iron supplement. In the process of iron supplementation to livestock, since the pH of the stomach environment is about 1, the acidity is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K9/52A61K47/38A61K47/32A61P3/02A23K20/20
CPCA23K20/30A61K9/5026A61K9/5047A61K9/5078A61K33/26A61P3/02
Inventor 舒绪刚林羽胡洪超田允波
Owner ZHONGKAI UNIV OF AGRI & ENG
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