Modified acellular vascular scaffold with surface compounded and ultrasonically coated with chitosan and preparation method thereof

Abstract

The invention provides a modified acellular vascular scaffold with the surface compounded and ultrasonically coated with chitosan and a preparation method thereof. A acellular vessel is taken as a vascular scaffold, after the vascular scaffold is processed under specific multigelation and superhigh pressure conditions and subjected to ultrasonic cavitation through the selected ultrasonic condition, the surface of the vascular scaffold can be coated with a chitosan material and tightly combined with the processed vessel through a method of ultrasonic wave precise spraying, compounding of chitosan and the vascular scaffold is achieved, and accordingly the good plasticity, the tensile strength and the elastic performance can be obtained integrally.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a modified decellularized vascular scaffold. Background technique [0002] With the increasing prevalence of cardiovascular disease, a large number of vascular substitutes will be required clinically in cardiovascular surgery. Tissue-engineered blood vessels have the potential of self-repair and remodeling, which improves the long-term patency rate and has a good application prospect. The materials of vascular stents can be divided into non-biological materials and biological materials. Biomaterials are divided into natural materials and decellularized fibrous tissue structure materials. Acellular vascular matrix belongs to the material of decellularized fibrous tissue structure. Since the direct transplantation of allogeneic blood vessels will cause obvious antigen rejection, and the antigenicity mainly comes from cells, it is necessary to remove the cells in the bl...

AI Technical Summary

Problems solved by technology

However, its plasticity, tensile strength and elastic properties are not ideal, and the tube wall is easy to collapse, which seriously limits its clinical application.

[0003] Although chitosan has good biocompatibility and is biodegradable in vivo, its tubular material has the problem of high brittleness. When the tube wall is thin, it is easy to break and collapse, and if the tube wall is made too thick, the absorption time will be prolonged. If the material stays in the body, it will cause local compression on the endogenous nerve, and the metabolites are acidic, which will have a certain adverse effect on nerve regeneration. Therefore, the vascular stent made of a single chitosan material cannot be used clinically, and the The thickness of polysaccharide materials is difficult to control