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Enteric algal polysaccharide vacant capsule and preparation method thereof

A technology of seaweed polysaccharides and hollow capsules, applied in the direction of capsule delivery, inorganic non-active ingredients, etc., to achieve high tolerance, reduce irritation, and control the effect of drug release speed

Inactive Publication Date: 2019-01-08
青岛聚大洋藻业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there are few reports on the application of seaweed polysaccharide capsules in drug release in the gastrointestinal tract

Method used

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  • Enteric algal polysaccharide vacant capsule and preparation method thereof
  • Enteric algal polysaccharide vacant capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A preparation method of enteric-coated seaweed polysaccharide hollow capsules, the preparation steps are as follows:

[0054] (1) dissolve

[0055] First add 85g of sodium alginate to an appropriate amount of 70°C pure water, soak, expand and stir in the sol tank to dissolve the sodium alginate;

[0056] (2) Sol

[0057] Stir the above ingredients at 70°C for 3 hours. After they are completely dissolved, add 15 g of hydroxymethyl starch, 2 g of glycerin, 0.03 g of food coloring and 4 g of titanium dioxide in sequence, and dissolve completely to prepare a glue solution with a concentration of 12%.

[0058] (3) Raw glue

[0059] After stirring evenly, transfer to an automatic temperature-controlled stainless steel bucket for glue cultivation, keep warm at 50°C, and after standing for 6 hours, remove the foam on the surface. After the glue cultivation, the viscosity of the glue reaches 2300mPa.s;

[0060] (4) dipped in glue

[0061] After the glue cultivation is comple...

Embodiment 2

[0073] A preparation method of enteric-coated seaweed polysaccharide hollow capsules, the preparation steps are as follows:

[0074] (1) dissolve

[0075] First add 90g of sodium alginate to an appropriate amount of 60°C pure water, soak, expand and stir in the sol tank to dissolve the sodium alginate;

[0076] (2) Sol

[0077] Stir the above ingredients for 4 hours at a temperature of 65°C. After they are completely dissolved, add 10 g of hydroxymethyl starch, 3 g of glycerin, 0.01 g of food coloring and 1 g of titanium dioxide in order to completely dissolve and prepare a glue solution with a concentration of 14%.

[0078] (3) Raw glue

[0079] After stirring evenly, transfer it to an automatic temperature-controlled stainless steel bucket for glue cultivation, keep it warm at 60°C, and after standing for 1.5 hours, remove the foam on the surface. After the glue cultivation, the viscosity of the glue reaches 2450mPa.s;

[0080] (4) dipped in glue

[0081] After the glue ...

Embodiment 3

[0093] A preparation method of enteric-coated seaweed polysaccharide hollow capsules, the preparation steps are as follows:

[0094] (1) dissolve

[0095] First add 80g of sodium alginate to an appropriate amount of 50°C pure water, soak, expand and stir in the sol tank to dissolve the sodium alginate;

[0096] (2) Sol

[0097] Stir the above ingredients at a temperature of 75°C for 2.5 hours. After they are completely dissolved, add 5 g of hydroxymethyl starch, 2.5 g of glycerin and 2 g of titanium dioxide in sequence, and dissolve them completely to prepare a glue solution with a concentration of 13%.

[0098] (3) Raw glue

[0099] After stirring evenly, transfer to an automatic temperature-controlled stainless steel barrel for glue cultivation, keep warm at 30°C, and after standing for 7 hours, remove the surface foam. After the glue cultivation, the viscosity of the glue reaches 2500mPa.s;

[0100] (4) dipped in glue

[0101] After the glue cultivation is completed, un...

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Abstract

The invention provides an enteric algal polysaccharide vacant capsule and a preparation method thereof. The enteric algal polysaccharide vacant capsule is prepared from the following raw materials: sodium alginate, hydroxymethyl starch, a plasticizer, a colorant and titanium dioxide. Meanwhile, the invention also discloses a preparation method of the enteric algal polysaccharide vacant capsule. The enteric algal polysaccharide vacant capsule disclosed by the invention has the benefits of reasonable matching, and simple and feasible preparation method; a main material of a finished capsule produced by the invention is sodium alginate; in a simulated gastric environment, sodium alginate easily forms hydrophilic colloid which is not easily digested, has high tolerance of acid, and changes thedisintegrating property of the capsule, so that the capsule can be kept in the stomach for 2 hours without disintegration, the drug release speed is effectively controlled, and the irritation of a drug to the stomach is reduced; however, the capsule can be all disintegrated in the simulated intestinal fluid environment within 1 hour, which shows that the capsule can be used for efficacy release of specific drugs in the intestine and has a good application prospect in the drug release aspect.

Description

technical field [0001] The invention relates to the technical field of seaweed polysaccharide, in particular to an enteric-coated seaweed polysaccharide hollow capsule and a preparation method thereof. Background technique [0002] Seaweed polysaccharide is a kind of multi-component mixture. So far, the research on its structure has mainly focused on the sugar units and content it contains. [0003] Seaweed polysaccharides mainly come from seaweeds such as kelp, bucktail (hijiki), giant algae, ascophyllum nodosum, fucus, asparagus, and Eucheuma. Seaweed polysaccharides mainly include algin, red algin, fucoidan and alginate. The crude products of algin, fucoidan and alginate isolated from kelp are white and slightly yellow powder. The purified sodium alginate is a white filament; the fucoidan is a milky white powder; both are soluble in water but insoluble in ethanol, acetone, chloroform and other organic solvents. Properties of red alginate (9000-21-9): Its appearance is...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/02
CPCA61K9/4816A61K47/02A61K47/36
Inventor 程跃谟吴仕鹏张璇周丽王萍
Owner 青岛聚大洋藻业集团有限公司
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