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Low-toxicity and high-efficiency nano-drug carrier material for tumor therapy and preparation method and application thereof

A nano-drug carrier and drug technology, applied in the direction of anti-tumor drugs, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of easy damage to normal cells, low tumor targeting, and short cycle time To achieve the effect of accelerating oxidative death, enhancing the effect of chemotherapy, and controlling the particle size

Active Publication Date: 2019-01-22
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this small molecule drug is a hydrophobic drug, and hydrophobic drugs have the obvious defects of short circulation in the body, low tumor targeting, and easy damage to normal cells, and the researchers found that the efficacy of DSF is largely It depends on the copper ion content in human tumor tissue, and oral or injection copper ion is relatively toxic to normal cells, which will cause serious side effects. Therefore, how to safely increase the copper ion content in the tumor is also an urgent problem to be solved.
However, there is no research on the use of copper ions on mesoporous SiO 2 report on modification

Method used

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  • Low-toxicity and high-efficiency nano-drug carrier material for tumor therapy and preparation method and application thereof
  • Low-toxicity and high-efficiency nano-drug carrier material for tumor therapy and preparation method and application thereof
  • Low-toxicity and high-efficiency nano-drug carrier material for tumor therapy and preparation method and application thereof

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preparation example Construction

[0031] figure 1 It is a flow chart of preparing nano drug carrier material according to one embodiment of the present invention. Such as figure 1 As shown, firstly, mesoporous silica can be prepared. However, it should be understood that in the present invention, mesoporous silica can also be purchased directly.

[0032] The preparation method of mesoporous silica is not limited, for example, mesoporous silica can be synthesized by sol-gel method using surfactant as structure directing agent and acid or alkali as catalyst. The surfactants used can be cationic surfactants or anionic surfactants or block copolymer surfactants, such as cetyltrimethylammonium chloride (CTAC), cetyltrimethylbromide ammonium (CTAB), etc. The acid used can be at least one of hydrochloric acid, nitric acid and sulfuric acid. The alkali used may be at least one of sodium hydroxide, ammonia water, triethylamine (TEA), and sodium carbonate. The precursor used can be tetraethyl orthosilicate (TEOS),...

Embodiment 1

[0041] (1) Preparation of mesoporous silica nanoparticles: Dissolve 2g CTAC and 0.02g TEA in 18mL deionized water, mix and stir evenly, then add 1.5mLTEOS in a 90°C water bath, react for four hours to obtain the product and centrifuge and wash it for later use.

[0042] (2) Preparation of copper ion-modified mesoporous silica (CuMSNs): 0.13 g mesoporous silica and 0.7 mmol Cu(NO 3 ) 2 After mixing evenly, add 12mL of ammonia water dropwise and stir evenly, then put it into a reaction kettle at 140°C to react for 10h, and the obtained product is washed by centrifugation.

[0043] (3) PEG modification on the surface of the material: Dissolve 10 mg of modified mesoporous silica in 100 mL of ethanol solution, add 50 mg of M-SLN-2000 (JenKem Technology) and stir at room temperature for 24 hours, then centrifuge and wash to obtain the product for later use.

[0044] (4) Copper ion-modified mesoporous silica-loaded DSF: Dissolve 20 mg of the PEGylated material in 2 mL of chloroform ...

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Abstract

The invention relates to a low-toxicity and high-efficiency nano-drug carrier material for tumor therapy and a preparation method and application thereof. The nano-drug carrier material comprises mesoporous silica and copper ions distributed on the mesoporous silica.

Description

technical field [0001] The invention belongs to the technical field of microporous / mesoporous molecular materials, and relates to a copper ion-modified mesoporous SiO with controllable particle size, high specific surface area, large pore volume and uniform pore size distribution. 2 Nanospheres and their related applications as a low-toxicity, high-efficiency nano-drug carrier material for tumor therapy. Background technique [0002] Disulfiram (DSF), the main ingredient of a cheap alcohol-abstinence drug, was later discovered to have a good anti-cancer effect, and it was soon clinically used and approved by the FDA. However, this small molecule drug is a hydrophobic drug, and hydrophobic drugs have the obvious defects of short circulation in the body, low tumor targeting, and easy damage to normal cells, and the researchers found that the efficacy of DSF is largely It depends on the copper ion content in human tumor tissue, and oral or injection copper ion is relatively to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/60A61K31/145A61K33/34A61P35/00
CPCA61K31/145A61K33/34A61K47/60A61K47/6949A61P35/00A61K2300/00
Inventor 吴文柽于罗丹陈雨施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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