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Preparation method and application of nitrofuran antibiotic sensor

A technology of nitrofuran and antibiotics, which is applied in the field of new nano-functional materials and biosensing analysis, can solve the problems of reduced sensitivity, reduced stability and reproducibility of electrochemical sensors, limiting the application of molecularly imprinted membranes, etc., and achieves excellent electronic performance. Transfer ability, convenient operation, and the effect of reducing testing costs

Active Publication Date: 2019-01-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • Preparation method and application of nitrofuran antibiotic sensor
  • Preparation method and application of nitrofuran antibiotic sensor
  • Preparation method and application of nitrofuran antibiotic sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of CoNi LDH-nanoarray

[0031] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0032] (2) Weigh 1 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 3 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0033] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 100°C for 12 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0034] (4) Insert the cobalt-nickel double metal layered hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a ...

Embodiment 2

[0036] Example 2 Preparation of CoNi LDH-nanoarray

[0037] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0038] (2) Weigh 2 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 6 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0039] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 110°C for 11 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0040] (4) Insert the cobalt-nickel double metal layered hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a ...

Embodiment 3

[0042] Example 3 Preparation of CoNi LDH-nanoarray

[0043] (1) Use dilute hydrochloric acid, absolute ethanol and deionized disposable electrode for ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0044] (2) Weigh 3 mmol Ni(NO 3 ) 2 and Co(NO 3 ) 2 mixture and 9 mmol urea CO(NH 2 ) 2 , put it into a 50mL beaker, add 30mL deionized water and stir until clear, then transfer to a 50mL polytetrafluoroethylene reactor;

[0045] (3) Put the disposable disposable electrode treated in step (1) into the solution in the reaction kettle in step (2), and react at a temperature of 130°C for 9 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0046] (4) Insert the cobalt-nickel double metal layered hydroxide nanosheet array precursor electrode obtained in step (3) into the phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a t...

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Abstract

The invention discloses a preparation method of a nitrofuran antibiotic sensor, and belongs to the technical field of new nano functional materials and biosensing analysis technology. The method comprises the following steps: firstly preparing an array of cobalt-nickel bimetal layered hydroxide nanosheets on a disposable electrode, directly preparing a polydopamine film containing an electron mediator and a molecularly imprinted polymer using the nitrofuran antibiotic as a template molecule successively on the array of cobalt-nickel bimetal layered hydroxide nanosheets one after another by adopting an in-situ growth method and utilizing a large specific surface area and high active hydroxyl functional groups, and eluting the molecularly imprinted polymer of the template molecule after thetemplate molecule is eluted and the original position of the template molecule became a hole, thereby preparing a nitrofuran antibiotic sensor.

Description

technical field [0001] The invention relates to a preparation method and application of an electrochemical analysis sensor. It belongs to the field of new nano functional material and biosensing analysis technology. Background technique [0002] Nitrofuran antibiotics are a class of 5-nitro-2 substituted furan derivatives, which used to be an important class of anti-infective drugs. Such drugs mainly include furazolidone, nitrofurantoin, nitrofurazone, etc., and are mainly used to treat urinary tract infections, intestinal bacterial infections, skin wound infections, and as food additives to prevent poultry intestinal infectious diseases. However, due to the genotoxicity and carcinogenic effects of furazolidone, its use in humans and animals has been banned by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) in 2005. Moreover, the cell mutagenicity and animal carcinogenicity of nitroheterocyclic compounds have attracted great attention in c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 张勇刘召壹魏琴
Owner UNIV OF JINAN
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