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A spray for vaginal pH environment adjustment and preparation method thereof

An environmental regulation and spray technology, applied in the field of medicine, can solve the problems of short vaginal pH environment maintenance time, limited vaginal administration area, vaginal mucosal irritation, etc., to reduce the number of administrations, facilitate growth, and reduce vaginal irritation. Effect

Active Publication Date: 2021-07-16
江苏中天药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a spray for vaginal pH environment adjustment, which can solve the problem that the area of ​​vaginal administration is limited in the traditional way of administration, the maintenance time of vaginal pH environment is short, and the administration is frequent. The problem of mucosal irritation, in addition, the present invention also provides a preparation method of a spray for vaginal pH environment regulation

Method used

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  • A spray for vaginal pH environment adjustment and preparation method thereof
  • A spray for vaginal pH environment adjustment and preparation method thereof
  • A spray for vaginal pH environment adjustment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 3

[0046] Experimental Example 3: Lactobacillus growth test

[0047] Configure 6 parts of agarose medium respectively, spray 2mL and pH 6.8 sterilized phosphate buffer evenly on the culture plate respectively, choose five parts of culture plates to spray the spray agent in the embodiment 1-5 of 5mL respectively, and then Lactobacillus was inoculated on a culture plate, incubated at 37°C for 24 hours, and its growth was observed. Another culture plate was used as a blank control experiment.

[0048] Result shows: the growth of lactobacillus is better in the test group of spraying agent in spraying embodiment 1-5, and matched group only has a small amount of growth and reproduction, figure 2 After presenting the spraying agent in spraying embodiment 1, the lactobacillus growth situation.

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Abstract

The invention discloses a spray for adjusting the pH environment of the vagina, which comprises the following components in parts by mass: 30-60 g / L of non-Newtonian fluid composition, 59 g / L of artificial vaginal fluid, and a pH buffer to adjust the pH to 3.5 ‑4.5. Appropriate amount of distilled water. The product of the present invention presents a gel state during storage, and the gel becomes thinner under the action of external pressure, and the viscosity decreases, which is beneficial to atomization and spraying, so that the spray is more uniformly dispersed in the vagina than the gel directly administered, and the effect The area is wider, and the spray becomes a viscous gel state without obvious external force in the vaginal wall, adhering to the vaginal mucosa, which prolongs the time for maintaining a stable pH environment.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a spray for adjusting the pH environment of the vagina and large-area administration of the vagina and a preparation method thereof. Background technique [0002] Vaginal fluid is composed of plasma exudate from the vaginal wall, glandular secretions, cervical mucus, endometrium and fallopian tube fluid, residual urine and exfoliated epithelial cells, etc. The characteristics and composition of this fluid largely determine Interactions between the microbiota and urogenital pathogens. Vaginal fluid contains water (90-95%), organic and inorganic salts, urea, carbohydrates, mucins, fatty acids, albumin, immunoglobulins, and other macromolecules. Contains a small amount of mannose and glucosamine. In addition to the main lactic acid and acetic acid, organic acids also contain a small amount of formic acid, succinic acid, propionic acid, butyric acid and sodium, potassium, chloride,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K47/10A61K47/38A61K47/32A61K47/12A61K45/00A61P15/02
CPCA61K9/0034A61K9/12A61K45/00A61K47/10A61K47/12A61K47/32A61K47/38A61P15/02
Inventor 管运才汤晓雷
Owner 江苏中天药业有限公司
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