Applications of potassium permanganate in preparation of medicines used for eradicative treatment of helicobacter pylori infection, and prepared medicines

Abstract

The invention provides applications of potassium permanganate in preparation of medicines used for eradicative treatment of helicobacter pylori infection, and the prepared medicines. According to applications, potassium permanganate of an appropriate concentration is rapidly degraded to release a large amount of oxygen in stomach, the oxygen concentration in the stomach is increased obviously, anderadicative treatment of helicobacter pylori infection is realized. It is confirmed by experiments that potassium permanganate of an appropriate concentration possesses both preferable killing effecton helicobacter pylori national standard strain and helicobacter pylori wild bacteria strain, and especially can be used for preventing generation of drug resistance of helicobacter pylori and recurrent infection. After treatment with potassium permanganate, no recurrence of mouse helicobacter pylori infected models is caused, eradicative treatment is realized, a novel selection is provided for medicines used for eradicative treatment of helicobacter pylori, and a novel idea is provided for clinical prevention and treatment of helicobacter pylori infection.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of potassium permanganate in the preparation of medicines for eradicating Helicobacter pylori infection and the prepared medicines. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative microaerophilic bacterium, and more than half of the world's population has Helicobacter pylori infection (Chen Hongcheng, Yang Bing. Epidemiological research progress of Helicobacter pylori infection[J] . Clinical Medicine Practice, 2014,23(12):942-945). Helicobacter pylori infection is closely related to various diseases of the stomach and duodenum. It is an important pathogenic factor of peptic ulcer and chronic gastritis, and is also the initiating factor of the evolution of gastric cancer. It is also related to the occurrence and development of gastric mucosa-associated lymphoid tissue lymphoma. It is closely related to the World Health Organization and designated as...

AI Technical Summary

Problems solved by technology

Although there are many methods for the treatment of Helicobacter pylori infection, they still cannot be completely eradicated

First, the disadvantages of bismuth quadruple therapy: the therapy consists of bismuth, antacid and two antibacterial drugs, and the course of treatment is 14 days

However, in the face of the high rate of antibacterial drug resistance in my country, changing the type of antibacterial drug, increasing the dose, and extending the course of treatment cannot effectively eradicate Helicobacter pylori infection, but lead to a further increase in the rate of drug resistance; second, the disadvantages of probiotic therapy : At present, there are only a few literatures reporting the use of probiotics to eradicate Helicobacter pylori infection (Li Yingyi, Wang Yuqin. Treatment of Helicobacter pylori infection—a current challenge[J]. Journal of Gastroenterology and Hepatology, 2018, 27(2 ):121-125), but the eradication rate of this therapy has yet to be confirmed by more reliable clinical data; third, the shortcomings of traditional Chinese medicine therapy: the traditional Chinese medicine for the treatment of Helicobacter Differences in methods and conditions lead to uneven drug efficacy, great differences in antibacterial ability, and overall low reliability. Fourth, the disadvantages of vaccine therapy: the current research and development of Helicobacter pylori vaccine is still in its infancy, and the stability of the vaccine, Safety and effectiveness still face a huge test

[0004] Potassium permanganate is an oxidizing agent, commonly known as gray manganese oxide and PP powder. It has a purple-black slender prismatic appearance with metallic luster, and its aqueous solution is a rose-red transparent liquid. It is widely used in clinical and food disinfection and detoxification after poisoning. It has not been reported that potassium permanganate can treat Helicobacter pylori infection

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