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A thermosensitive liquid crystal nano hydrogel and its preparation method and application

A nano-hydrogel and temperature-sensitive technology, which can be used in applications, pharmaceutical formulations, liquid delivery, etc., can solve the problems of weak slow-release effect, no temperature sensitivity, and poor biocompatibility of hydrogel preparations. Achieve the effects of increasing drug loading and encapsulation efficiency, improving bioavailability, and easy raw materials

Active Publication Date: 2020-12-29
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention solves the technical problems in the prior art that the slow-release effect of the hydrogel preparation is not strong, the biocompatibility is poor, the phenomenon of hemolysis is caused, and the temperature sensitivity is not possessed

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  • A thermosensitive liquid crystal nano hydrogel and its preparation method and application
  • A thermosensitive liquid crystal nano hydrogel and its preparation method and application
  • A thermosensitive liquid crystal nano hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]A kind of preparation method of thermosensitive liquid crystal nano hydrogel, see flow chart figure 1 .

[0040] (1) Dissolve the liquid crystal material glyceryl dioleate (GDO) and soybean phosphatidylcholine (SPC) in a co-solvent at 25°C-50°C. The mass ratio of the alkali (SPC) is 1:1, and a surfactant is added to obtain a liquid crystal precursor;

[0041] (2) Under ultrasonic conditions, add the liquid crystal precursor described in step (1) dropwise into deionized water or a water-soluble drug solution to obtain a liquid crystal nanohydrogel; after removing the cosolvent by rotary evaporation, add Temperature-sensitive materials, that is, temperature-sensitive liquid crystal nano hydrogels are obtained.

[0042] Take the prepared SPC / GDO liquid crystal precursor preparation and prepare 50mg / mL, 75mg / mL and 100mg / mL nano-solutions respectively according to the prescription in Table 1 for use.

[0043] Table 1 Preparation of nano-solutions with different concentrat...

Embodiment 2

[0057] Weigh 0.5g of glyceryl dioleate and 0.5g of soybean phosphatidylcholine, and add them to 0.2g of absolute ethanol to dissolve at 40°C to obtain a liquid crystal precursor; due to the above ratio of soybean phosphatidylcholine Alkali and diolein liquid crystal precursors can quickly form liquid crystal gels with high strength after meeting water, so in theory, the above-mentioned soybean phosphatidylcholine and diolein liquid crystal precursors are slowly and gradually synthesized under ultrasonic conditions. Adding it dropwise into the water phase can disperse it to obtain a uniform liquid crystal nanogel solution.

[0058] During the operation, it was found that when using a single-channel pipette to absorb the liquid crystal precursor and drop it into the water, due to the high viscosity of the liquid crystal precursor and the small diameter of the pipette gun tip, it is easy to cause blockage, and it is almost impossible to remove the liquid crystal precursor. Drop i...

Embodiment 3

[0062] For the samples that can be gelled, when the temperature of the sample is lowered, the sample can become fluid again, and can be gelled when the temperature is raised, indicating that the gelation process of the hybrid nanogel system has good reversibility.

[0063] In order to show the phase transition temperature of the mixed nanogel system more intuitively, it is planned to use a rheometer to measure the elastic modulus (G') and viscous modulus (G") of the mixed nanogel system, when tan(δ)= 1, that is, when the loss tangent = G" / G' = 1, the corresponding temperature at this time is regarded as the phase transition temperature of the mixed nanogel system.

[0064] Take 200 uL of the sample of group 3 in Table 2, and put it into the test pan of the rheometer, set the frequency to 1 Hz, the strain to 0.3%, and the temperature rise range: 20°C to 40°C. The heating rate is 1°C / min. To prevent the evaporation of water in the mixed nanogel system from affecting the results...

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Abstract

The invention discloses thermo-sensitive liquid-crystal nanometer hydrogel, as well as a preparation method and application thereof, and belongs to the technical field of medicinal preparations. The hydrogel is prepared from 5 to 20 percent by weight of liquid crystal material, 0.2 to 2 percent by weight of surfactant, 12 to 25 percent by weight of thermo-sensitive material and 60 to 70 percent byweight of deionized water. The preparation method comprises the following steps: dissolving the liquid crystal material in a cosolvent, and adding the surfactant to obtain a liquid crystal precursor;adding the liquid crystal precursor into the deionized water or water-soluble medicinal solution dropwise under the condition of ultrasonic or high-pressure homogenization to obtain liquid-crystal nanometer hydrogel; adding the thermo-sensitive material into the liquid crystal nanometer hydrogel to obtain the thermo-sensitive liquid crystal nanometer hydrogel. The hydrogel preparation can be usedfor embolizing blood vessels through in-situ tumor vaccination or an intervention technique, release of different coated medicines can be effectively controlled by using external network structures of hydrogel containing liquid crystal nanoparticles and internal particular liquid crystal phase structures, blood concentration at target position is enhanced, and the bioavailability is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a temperature-sensitive liquid crystal nano hydrogel and its preparation method and application. Background technique [0002] Liquid crystal is a molecular aggregate with long-range order and short-range disorder. It is the fourth state besides the three states of matter. It is a thermodynamically stable intermediate phase state between solid and liquid. On the one hand, it has a flow like a liquid. On the other hand, it has anisotropy like crystal, which is a kind of substance with special structure. Liquid crystals can be divided into lyotropic liquid crystals and thermotropic liquid crystals. Lyotropic liquid crystals are mainly a system formed by two or more components under certain conditions. This system is mostly composed of amphiphilic molecules and solvents. When amphiphilic molecules and solvents When mixed, the solvent impregnates the solid latt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/14A61K47/24A61K47/10A61K47/32A61K45/06A61K31/513A61P35/00A61L24/00A61L24/04A61L24/06
CPCA61K9/06A61K31/513A61K45/06A61K47/10A61K47/14A61K47/24A61K47/32A61L24/00A61L24/001A61L24/0015A61L24/0031A61L24/046A61L24/06A61L2300/602A61L2400/06A61P35/00C08L71/02C08L33/24
Inventor 罗亮黄丽萍张一漪孟凡玲
Owner HUAZHONG UNIV OF SCI & TECH
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