Method for detecting 5-Isoquinolinesulfonic acid in fasudil hydrochloride
A technology of ethyl isoquinolinesulfonate and fasudil hydrochloride, which is applied in the field of detection of ethyl 5-isoquinolinesulfonate in fasudil hydrochloride, can solve the problem of 5-isoquinolinesulfonate Ethyl acetate detection method, ineffective detection, long running time and other problems, to achieve the effect of high detection sensitivity, good for safety control, and short running time
Active Publication Date: 2019-02-22
KPC PHARM INC
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The invention belongs to the field of medicinal chemistry analysis and particularly relates to a method for detecting 5-Isoquinolinesulfonic acid in fasudil hydrochloride. The method is that a high-performance liquid chromatography-mass spectrum system is adopted to detect a 5-Isoquinolinesulfonic acid reference substance solution and a fasudil hydrochloride test sample solution. According to thedetecting method, the high performance liquid chromatography is firstly adopted for component separation, the position of a chromatographic peak of the 5-Isoquinolinesulfonic acid in the fasudil hydrochloride test sample solution can be determined under the chromatographic condition, the chromatographic peak of the 5-Isoquinolinesulfonic acid is effectively separated from chromatographic peak of adjacent other components, and the operation time is short; then, the mass spectrum condition is adopted to quantify a ternary quadrupole rod mass spectrum, ppm level of 5-Isoquinolinesulfonic acid canbe detected, and the limit of quantitation can reach ng/ml. Therefore, the 5-Isoquinolinesulfonic acid in fasudil hydrochloride can be effectively controlled.
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Property | Measurement | Unit |
Length | 50.0 | mm |
The inside diameter of | 4.6 | mm |
Particle size | 5.0 | µm |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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