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A chitin nano whisker/hydroxyapatite composite artificial bone material and its preparation method and application in 3D printing

A technology of chitin nanocrystals and hydroxyapatite, which is applied in the medical field to achieve the effects of anticoagulant wound healing, good bone conduction, and promoting wound healing

Active Publication Date: 2021-10-19
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Neither hydroxyapatite nor chitin nanowhiskers are harmful to the human body, and chitin nanowhiskers have the characteristics of high strength and high modulus. How to combine the two to prepare artificial bones suitable for human body has not been reported yet.

Method used

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  • A chitin nano whisker/hydroxyapatite composite artificial bone material and its preparation method and application in 3D printing
  • A chitin nano whisker/hydroxyapatite composite artificial bone material and its preparation method and application in 3D printing
  • A chitin nano whisker/hydroxyapatite composite artificial bone material and its preparation method and application in 3D printing

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preparation example Construction

[0029] Below in conjunction with accompanying drawing and specific steps the present invention is described in further detail, see figure 1 , the invention discloses a preparation method of chitin nano-whiskers / hydroxyapatite composite artificial bone material. The preparation process specifically includes the following steps:

[0030] Step 1, preparing colloidal chitin nano whiskers

[0031] Soak 2g~5g of chitin in 100ml of hydrochloric acid, the concentration of hydrochloric acid is 3mol / L, put it in a Erlenmeyer flask, heat it to boiling under mechanical stirring, and react for 2~4 hours to form a gelatinous product; in the gelatinous product Add water to ensure that the amount of water added can completely submerge the colloidal product to dilute the colloidal product. Stir the mixture evenly to form a mixed solution; centrifuge the mixed solution at a speed of 5000-9000r / min for 6-10 minutes, and then pour it out supernatant, and repeat the centrifugation once; colloidal c...

Embodiment 1

[0049] Step 1, preparing colloidal chitin nano whiskers

[0050] Soak 2g of chitin in 100ml of hydrochloric acid, the concentration of hydrochloric acid is 3mol / L, put it in an Erlenmeyer flask, heat it to boiling under mechanical stirring, and react for 4 hours to form a gelatinous product; add water to the gelatinous product to dilute Colloidal product, after the mixture is stirred evenly, a mixed solution is formed; the mixed solution is centrifuged at a speed of 5000r / min for 10min, then the supernatant is poured off, and the above centrifugation is repeated once; after centrifugation, a colloidal chitin nanowhiskers.

[0051] Step 2, remove the acidic substances in the colloidal chitin nano whiskers

[0052] Put the chitin nano-whiskers that step 1 obtains into the dialysis bag, carry out the first dialysis, the dialysis time is 8h, the consumption of dialysate is 50 times of chitin nano-whiskers, and the dialysate is selected tap water; Ionized water is carried out sec...

Embodiment 2

[0066] Step 1, preparing colloidal chitin nano whiskers

[0067] Soak 5g of chitin in 100ml of hydrochloric acid, the concentration of hydrochloric acid is 3mol / L, put it in an Erlenmeyer flask, heat it to boiling under mechanical stirring, and react for 3 hours to form a gelatinous product; add water to the gelatinous product to dilute Colloidal product, after the mixture is stirred evenly, a mixed solution is formed; the mixed solution is centrifuged at a speed of 9000r / min for 6min, then the supernatant is poured off, and the above centrifugation is repeated once; after centrifugation, a colloidal chitin nanowhiskers.

[0068] Step 2, remove the acidic substances in the colloidal chitin nano whiskers

[0069] Put the chitin nano-whiskers that step 1 obtains into the dialysis bag, carry out the first dialysis, the dialysis time is 12h, the consumption of the dialysate is 20 times of the chitin nano-whiskers, and the dialysate is selected deionized water; Carry out second d...

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Abstract

The invention discloses a chitin nano whisker / hydroxyapatite composite artificial bone material, a preparation method thereof and an application in 3D printing. The preparation method combines chitin nano-whiskers and hydroxyapatite through a solid-state reaction method; when the prepared composite material has the characteristics of high strength of hydroxyapatite, the purpose of using whiskers to enhance the toughness of biological materials At the same time, chitin makes the material not only have good osteoconduction, osteoinduction and biocompatibility, but also has anti-inflammatory, analgesic, anticoagulant and wound healing effects; the chitin nano whiskers / When the hydroxyapatite composite artificial bone material is applied to the preparation of artificial bone, it is found that the compressive strength of the artificial bone prepared by pure hydroxyapatite material is increased by 32.6%, and the elastic modulus is decreased by 18.4%.

Description

【Technical field】 [0001] The invention belongs to the field of medical technology, and in particular relates to a chitin nano-whisker / hydroxyapatite composite artificial bone material, a preparation method thereof, and an application in 3D printing. 【Background technique】 [0002] Bone defects caused by fractures, bone tumors, trauma and infection need to be repaired by bone grafting. Bone transplantation is divided into autologous bone graft, allogeneic bone graft, xenograft bone graft and artificial bone graft. Among them, artificial bone transplantation has become an inevitable trend in the field of bone repair because it breaks through the source limitation and avoids the risks of immunity and viruses. [0003] In recent years, the preparation of artificial bone scaffolds has been rapidly developed in bone tissue engineering. Various new materials have been used to prepare bone scaffolds, and the complementary mechanisms of various materials have been used to prepare co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/50A61L27/54A61L27/56B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/12A61L27/20A61L27/50A61L27/54A61L27/56A61L2300/236A61L2300/402A61L2300/41A61L2300/412A61L2300/42A61L2400/12A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L5/08
Inventor 曾庆丰魏静
Owner 西安点云生物科技有限公司
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