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Aluminum ion and zinc ion recognition dual-functional fluorescence probe and preparation and application methods

A fluorescent probe, zinc ion technology, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of low selectivity and sensitivity, cumbersome probe synthesis steps, etc. The effect of strong anti-interference ability and broad application prospects

Active Publication Date: 2019-03-08
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of cumbersome synthesis steps, low selectivity and low sensitivity of existing probes for individually identifying aluminum ions or zinc ions, and provides a dual-functional fluorescent probe for identifying aluminum ions and zinc ions and a preparation method thereof and application

Method used

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  • Aluminum ion and zinc ion recognition dual-functional fluorescence probe and preparation and application methods
  • Aluminum ion and zinc ion recognition dual-functional fluorescence probe and preparation and application methods
  • Aluminum ion and zinc ion recognition dual-functional fluorescence probe and preparation and application methods

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specific Embodiment approach 1

[0037] Specific embodiment 1: The bifunctional fluorescent probe for recognizing aluminum ions and zinc ions in this embodiment is a covalent combination of 2-(2-hydroxyphenyl)benzothiazole and salicylhydrazide, and the bifunctional fluorescent probe The structural formula is as follows:

[0038]

specific Embodiment approach 2

[0039] Specific embodiment two: the method for preparing a bifunctional fluorescent probe for recognizing aluminum ions and zinc ions in this embodiment includes the following steps:

[0040] 1. Compound 1 is obtained by reacting 5-methyl salicylaldehyde with o-aminothiophenol:

[0041] Dissolve 5-methylsalicylaldehyde and o-aminothiophenol in N,N-dimethylformamide (DMF), then add sodium pyrosulfite, heat to reflux, the heating temperature is 110-120°C, reaction 3 ~4h, use a TCL plate to detect the reaction. After the reaction is complete, add deionized water to the solution after cooling to room temperature, and a pale yellow precipitate precipitates out. Filter the precipitate, wash it with deionized water for 5 to 6 times, and obtain compound 1 after drying;

[0042] Wherein the mol ratio of 5-methyl salicylaldehyde and o-aminothiophenol is 1:1;

[0043] Two, the compound 1 obtained in step 1 is reacted with urotropine to obtain compound 2:

[0044]Dissolve compound 1 and...

specific Embodiment approach 3

[0048] Embodiment 3: This embodiment is different from Embodiment 2 in that in step 3, after compound 2 and salicylhydrazide are added to ethanol, glacial acetic acid is added until the pH of the reaction system is 4-6. Others are the same as in the second embodiment.

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Abstract

An aluminum ion and zinc ion recognition dual-functional fluorescence probe and preparation and application methods relate to dual-functional fluorescence probes and preparation and application methods thereof. The aluminum ion and zinc ion recognition dual-functional fluorescence probe and the preparation and application methods solve the problem that existing probes for independently identifyingaluminum ions or zinc ions are cumbersome in synthetic procedures and low in selectivity and sensitivity. The aluminum ion and zinc ion recognition dual-functional fluorescence probe is a covalent combination of 2-(2-hydroxyphenyl)-benzothiazole and salicylhydrazide. The preparation method of the aluminum ion and zinc ion recognition dual-functional fluorescence probe comprises, firstly, subjecting 5-methyl salicylaldehyde and o-aminobenzenethiol to reaction to obtain a compound 1; secondly, subjecting the compound 1 and urotropine to reaction to obtain a compound 2; thirdly, subjecting the compound 2 and salicylhydrazide to reaction to obtain a target compound Z. The preparation method of the aluminum ion and zinc ion recognition dual-functional fluorescence probe completes synthesis within three steps and is simple in aftertreatment process; the prepared aluminum ion and zinc ion recognition dual-functional fluorescence probe can achieve sensitive detection of aluminum ions and zincions and is good in selectivity, high in anti-interference capacity and low in detection limit. The aluminum ion and zinc ion recognition dual-functional fluorescence probe is applied to detecting heavy metal ions.

Description

technical field [0001] The invention relates to a bifunctional fluorescent probe and its preparation method and application. Background technique [0002] As we all know, the content of aluminum in the earth's crust is second only to oxygen and silicon, ranking third, and is the most abundant metal element in the earth's crust. Its compounds are widely found in the production of water treatment, food additives, medicines and light alloys, etc. . As a non-essential element for the human body, the widespread use of aluminum causes people to take in too much aluminum, which will accumulate in different tissues and organs of the human body, causing various diseases, such as microcytic hypochromic anemia, Aluminum bone-related diseases, encephalopathy, myopathy, dementia and Alzheimer's disease, etc. In addition, trivalent aluminum ions widely exist in many plants and animal tissues, and exist in natural water systems. Excessive aluminum ions will cause some fish in the water ...

Claims

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Application Information

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IPC IPC(8): C07D277/66C09K11/06G01N21/33G01N21/64
CPCC07D277/66C09K11/06C09K2211/1037G01N21/33G01N21/643G01N21/6447
Inventor 邢志勇曾爽李明强孙雪娇
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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