A bifunctional fluorescent probe for recognizing aluminum ions and zinc ions and its preparation method and application

A technology of fluorescent probes and zinc ions, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of low selectivity and sensitivity, cumbersome probe synthesis steps, etc.

Active Publication Date: 2021-05-07
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of cumbersome synthesis steps, low selectivity and low sensitivity of existing probes for individually identifying aluminum ions or zinc ions, and provides a dual-functional fluorescent probe for identifying aluminum ions and zinc ions and a preparation method thereof and application

Method used

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  • A bifunctional fluorescent probe for recognizing aluminum ions and zinc ions and its preparation method and application
  • A bifunctional fluorescent probe for recognizing aluminum ions and zinc ions and its preparation method and application
  • A bifunctional fluorescent probe for recognizing aluminum ions and zinc ions and its preparation method and application

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specific Embodiment approach 1

[0037] Embodiment 1: The bifunctional fluorescent probe for identifying aluminum ions and zinc ions in this embodiment is a covalent conjugate of 2-(2-hydroxyphenyl)benzothiazole and salicylic hydrazide. The structure is as follows:

[0038]

specific Embodiment approach 2

[0039] Specific embodiment 2: The preparation method of the bifunctional fluorescent probe for identifying aluminum ions and zinc ions in this embodiment includes the following steps:

[0040] One, 5-methylsalicylaldehyde reacts with o-aminothiophenol to obtain compound 1:

[0041] Dissolve 5-methylsalicylaldehyde and o-aminothiophenol in N,N-dimethylformamide (DMF), then add sodium metabisulfite, heat to reflux, and the heating temperature is 110~120°C, reaction 3 After ~4h, the reaction was detected by TCL plate. After the reaction was completed, deionized water was added to the solution after cooling to room temperature, and a pale yellow precipitate was precipitated. The precipitate was filtered, washed with deionized water for 5 to 6 times, and dried to obtain compound 1;

[0042] Wherein the mol ratio of 5-methylsalicylaldehyde and o-aminothiophenol is 1:1;

[0043] 2. The compound 1 obtained in step 1 is reacted with urotropine to obtain compound 2:

[0044]Compound 1...

specific Embodiment approach 3

[0048] Embodiment 3: The difference between this embodiment and Embodiment 2 is that in step 3, after adding compound 2 and salicylic hydrazide to ethanol, glacial acetic acid is also added until the pH of the reaction system is 4-6. Others are the same as in the second embodiment.

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Abstract

A bifunctional fluorescent probe for recognizing aluminum ions and zinc ions, its preparation method and application, relates to a bifunctional fluorescent probe, its preparation method and application. The purpose of the method is to solve the problems of cumbersome synthesis steps, low selectivity and low sensitivity of existing probes for individually recognizing aluminum ions or zinc ions. The bifunctional fluorescent probe is a covalent combination of 2‑(2‑hydroxyphenyl)benzothiazole and salicylhydrazide. Method: 1. Compound 1 is obtained by reacting 5-methyl salicylaldehyde with o-aminothiophenol; 2. Compound 2 is obtained by reacting compound 1 with urotropine; 3. Compound 2 is reacted with salicylhydrazide to prepare Target compound Z. The synthesis of the probe of the present invention can be completed in only three steps, and the post-processing process is relatively simple; the probe can identify aluminum ions and detect zinc ions, and has good selectivity, strong anti-interference ability, and high detection efficiency. low limit. The bifunctional fluorescent probe of the invention is used for detecting heavy metal ions.

Description

technical field [0001] The present invention relates to a bifunctional fluorescent probe and its preparation method and application. Background technique [0002] As we all know, aluminum is the third most abundant metal element in the earth's crust after oxygen and silicon, and its compounds are widely used in the production of water treatment, food additives, medicines and light alloys, etc. . As a non-essential element in the human body, the widespread use of aluminum makes people ingest too much aluminum, and the excess aluminum will accumulate in different tissues and organs of the human body, causing various diseases, such as microcytic hypochromic anemia, Aluminum bone-related diseases, encephalopathy, myopathy, dementia and Alzheimer's disease, etc. In addition, trivalent aluminum ions are widely present in many plant and animal tissues, and exist in natural water systems. Excessive aluminum ions put some fish in the water at risk of extinction. In acidic soils, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D277/66C09K11/06G01N21/33G01N21/64
CPCC07D277/66C09K11/06C09K2211/1037G01N21/33G01N21/643G01N21/6447
Inventor 邢志勇曾爽李明强孙雪娇
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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