Application of adenosine triphosphate in preparation of slimming product for external use

A technology of adenosine triphosphate and adenosine phosphate, which is applied in the field of medicine, can solve the problems that adenosine triphosphate has not been reported, and achieve the effect of reducing fat mass

Inactive Publication Date: 2019-03-15
广州涵夏基因健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no report on the fat-reduci

Method used

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  • Application of adenosine triphosphate in preparation of slimming product for external use
  • Application of adenosine triphosphate in preparation of slimming product for external use
  • Application of adenosine triphosphate in preparation of slimming product for external use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation of adenosine triphosphate

[0030] When the temperature of the reaction pot is 20°C, put magnesium chloride solution, benzalkonium bromide solution, and adenosine solution in sequence, continue to heat the reaction solution to 36-39°C, keep it warm, and start sampling to measure the conversion rate of adenosine triphosphate when the reaction reaches End the reaction when the adenosine triphosphate band appears, then add NaOH solution in proportion to continue the reaction, and obtain the pure product of adenosine triphosphate disodium salt through removal of impurities, elution, crystallization and drying.

[0031] 2. Preparation of quince extract, centella asiatica extract and kelp extract

[0032] Preparation of Vitex quinquefolium extract

[0033] Weigh the dry plant powder of Vitex japonicus, add 5 times the amount of ethanol to the dry powder, extract twice at room temperature, each time for 3 days, concentrate under reduced pressure, and filter to ...

Embodiment 2

[0039] 1. Test method

[0040] 3T3-L1 preadipocytes were induced to differentiate into adipocytes. Rat fibroblast cell line 3T3-L1 was used at 5×10 4 The cells were inoculated into 12-well culture plates at a density of 1 / ml, and cultured in high-glucose DMEM medium (GIBCO, Life technology) containing 10% fetal bovine serum (FBS, GIBCO, Life technology). When the cells reached 70% confluence, the culture medium was replaced with a medium containing 1 μg / ml insulin, 0.25 μmol / L dexamethasone and 0.5 mmol / L 3-isobutyl-1-methyl yellow Purine (IBMX) in new DMEM medium (containing 10% FBS) to induce differentiation; 2 days later, the medium was changed to 1 μg / ml insulin in new DMEM medium (containing 10% FBS); 2 days later, the medium was changed to into normal DMEM medium (containing 10% FBS) and observed until adipocytes were formed.

[0041] Experimental method 1: Detect the accumulation of fat by Oil Red O staining method and microplate reader. Use Oil Red O purchased from...

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Abstract

The invention relates to application of adenosine triphosphate in preparation of a slimming product for external use, and belongs to the technical field of medicines. The adenosine triphosphate is converted into cyclic adenosine monophosphate by cyclic adenosine phosphatase in adipose cells, then protein kinase A is activated, the protein kinase can activate lipase and catalyze fat to break up thefat into free fatty acid and glycerinum, and thus, a purpose of eliminating fat is achieved; and by the adenosine triphosphate, the fat mass in the adipose cells can be reduced, and the adenosine triphosphate can be developed into the slimming product for external use.

Description

technical field [0001] The invention relates to the application of adenosine triphosphate in the preparation of external fat-reducing and weight-reducing products, and belongs to the technical field of medicine. Background technique [0002] Obesity can be divided into systemic obesity and partial obesity (upper body obesity, lower body obesity, and abdominal obesity) according to the distribution of body fat tissue. Systemic obesity has become a global and serious social public health problem. According to statistics released by the World Health Organization, there are currently at least 1 billion overweight adults in the world, and 300 million people are obese. Population obesity has seriously threatened global development. Although partial obesity generally does not cause serious health problems, it is a more common social problem. It refers to the obesity that occurs due to excessive accumulation of fat in a certain part of the body, such as the abdomen (general belly / b...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61K36/23A61P3/04A61K8/9789A61K8/9741A61K8/9711A61K8/60A61K8/44A61Q19/06A61K31/205
CPCA61K8/44A61K8/602A61K8/9711A61K8/9741A61K8/9789A61K9/0014A61K31/205A61K31/7076A61K36/03A61K36/11A61K36/23A61P3/04A61Q19/06A61K2300/00
Inventor 谭杰峰王伟章涂传明
Owner 广州涵夏基因健康科技有限公司
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