Preparation method of modified nano-hydroxyapatite composite material for dental restoration

A nano-hydroxyapatite and composite material technology, applied in dental preparations, dentistry, dental prosthesis, etc., can solve the problems of high crystallinity and structural stability, poor antibacterial performance of nHAP, and unfavorable caries prevention and restoration, etc., to achieve Good antibacterial properties, easy to retain biological activity, and achieve the effect of in situ repair

Inactive Publication Date: 2019-03-22
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic nHAP has poor antibacterial properties, high crystallinity and structural

Method used

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  • Preparation method of modified nano-hydroxyapatite composite material for dental restoration
  • Preparation method of modified nano-hydroxyapatite composite material for dental restoration
  • Preparation method of modified nano-hydroxyapatite composite material for dental restoration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 1.126g of glycine, 1.727g of proline and 1.997g of aspartic acid to make solution A, and heat it to 37℃ for later use. , wherein the molar ratio of soluble calcium salt to compound amino acid is 1:3.

[0026] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water to make solution B for later use.

[0027] (3) Use a graduated cylinder to measure 20ml of ammonia water into 200ml of deionized water, and make it into a pH regulator for later use.

[0028] (4) Use a pH regulator to adjust the pH of solution A to 10.0, then slowly drop solution B into solution A (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and keep The pH of the reaction solution is 10.0±0.5, and the temperature is 37±1°C.

[0029] (5) Continue to stir for 24 hours after the titration, keep the temperatur...

Embodiment 2

[0033] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 3.153g of serine and 8.828g of glutamic acid respectively to prepare solution A, heat to 30°C for later use, in which soluble calcium salt and compound The molar ratio of amino acids is 1:6.

[0034] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water, add 0.0593g of graphene oxide powder, ultrasonically disperse evenly, and prepare solution B for later use, in which the mass ratio of soluble phosphate to graphene oxide is 1: 0.05.

[0035] (3) Use a graduated cylinder to measure 20ml of ammonia water into 200ml of deionized water, and make it into a pH regulator for later use.

[0036] (4) Use a pH regulator to adjust the pH of solution A to 9.0, then slowly drop solution B into solution A (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and keep The pH of the react...

Embodiment 3

[0041] (1) Weigh 3.542g of calcium nitrate tetrahydrate and dissolve it in 400ml of deionized water. After fully dissolving, add 0.075g of glycine and 0.067g of aspartic acid respectively to prepare solution A and heat it to 45°C for later use. The soluble calcium salt and The molar ratio of compound amino acids is 1:0.1.

[0042] (2) Weigh 1.186g of diammonium hydrogen phosphate and dissolve it in 200ml of deionized water, add 0.1186g of graphene oxide powder, ultrasonically disperse evenly, and prepare solution B for later use, in which the mass ratio of soluble phosphate to graphene oxide is 1: 0.1.

[0043] (3) Use a graduated cylinder to measure 20ml of ammonia water into 200ml of deionized water, and make it into a pH regulator for later use.

[0044] (4) Use a pH regulator to adjust the pH of solution A to 10.0, then slowly drop solution B into solution A (the stoichiometric ratio of Ca / P in soluble calcium salt and soluble phosphate is 1.67), and keep The pH of the r...

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Abstract

The invention relates to a preparation method of a modified nano-hydroxyapatite composite material for dental restoration and belongs to the field of biomedical materials. The modified nano-hydroxyapatite composite material is obtained by taking soluble calcium salt and soluble phosphate as raw materials, taking compound amino acid and/or graphene oxide as a modification means and adopting a chemical homogeneous precipitation method. The composite material has the following structure characteristics: the composite material has an enamel-like nanorod-shaped structure with the particle diameterof 3 to 30 nm and the length of 50 to 300 nm, and has a relatively low crystallization degree. The composite material prepared by the invention has good biosafety and biocompatibility, and has a goodrestoration effect on enamel or dentin surface demineralization and deep-layer demineralization; a new remineralization restoration layer can be formed on a demineralized enamel or dentin surface through nucleation, so that the surface hardness and antibacterial performance of teeth are improved and novel possibility is provided for clinical remineralization restoration of the teeth.

Description

technical field [0001] The invention relates to a preparation method of a modified nano-hydroxyapatite composite material for tooth restoration; it belongs to the field of biomedical materials. Background technique [0002] Teeth are morphological, highly calcified tissues that function in chewing, aiding in pronunciation, and maintaining facial shape. The part of the tooth that is exposed to the oral environment is enamel, the white, translucent tissue that is the hardest substance in the human body. Its unique mechanical properties are attributed to the prismatic structure of parallel micro- and nano-scale hydroxyapatite glaze columns interleaved with a softer protein matrix. The formation of enamel is a process of cell-mediated extracellular mineralization. With the maturation of minerals, cell apoptosis is accompanied by the continuous decomposition of organic substances such as amelogenin, and finally a tooth with a mineral content of 92-96wt% is obtained. enamel. Th...

Claims

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Application Information

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IPC IPC(8): A61K6/033A61K6/02A61K6/027A61K6/00A61K6/838
CPCA61K6/60A61K6/80A61K6/831A61K6/838
Inventor 陈庆华刘继涛颜廷亭陈希亮
Owner KUNMING UNIV OF SCI & TECH
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