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Core-satellite structure gold nanoparticle and preparation method thereof

A gold nanoparticle and satellite structure technology, which is applied in the fields of nanomaterials and analytical chemistry, can solve the problems of large core-satellite particle spacing, satellite particles cannot be linked, and low yield of composite particles, so as to facilitate large-scale production and good Effects of Biocompatibility, Particle Size and Morphology Uniformity

Active Publication Date: 2019-04-02
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The use of small molecular linkers inevitably leads to the inability of some satellite particles to link with the core particles, resulting in the waste of satellite particles; the use of macromolecular linkers often has problems such as low yield of composite particles and large structural differences, and the core-satellite particle The interval is large, which is not conducive to the formation of hot spots

Method used

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  • Core-satellite structure gold nanoparticle and preparation method thereof
  • Core-satellite structure gold nanoparticle and preparation method thereof
  • Core-satellite structure gold nanoparticle and preparation method thereof

Examples

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Effect test

Embodiment 1

[0035] With 80nm gold spheres as the core and egg yolk lecithin as the linker, gold nanoparticles with a core-satellite structure were prepared by using chloroauric acid in situ reduction to generate "satellite" gold nanoparticles (see figure 1 ):

[0036] (1) Preparation of gold nanosphere core:

[0037] Preparation of 80nm gold sphere core: First, take 50 μl of chloroauric acid (50mM) and dissolve it in 4.95ml of pure water, add 5ml of hexadecyltrimethylammonium bromide (0.2M), stir well, and put it at 27°C , add 600μl of ice-cold (below 0°C) 0.01M sodium borohydride to react for 15min, and after standing for 3h, gold seeds are obtained; then, add 2ml cetyltrimethylammonium chloride (0.2M), 1.5ml Ascorbic acid (0.1M), 50μl of the above gold seed solution was stirred and mixed thoroughly, and 2ml of chloroauric acid (0.5mM) was added to react at 27°C for 15min. In ammonium chloride (0.02M), a 10 nm gold nuclei solution was obtained. Mix 40ml of cetyltrimethylammonium chlor...

Embodiment 2

[0045] With 80nm gold spheres as the core and egg yolk lecithin as the linker, sodium dibromide bromoaurate is used to reduce in situ to generate "satellite" gold nanoparticles to prepare gold nanoparticles with a core-satellite structure. The difference from Example 1 in:

[0046] Preparation of sodium bromide bromoaurate solution: Weigh 0.2g of sodium bromide and dissolve it in 3ml of pure water to obtain a sodium bromide solution, add 120μl of chloroauric acid (50mM) to 1.98ml of pure water, and add 300μl of the above Sodium bromide solution, finally add 0.1M ascorbic acid dropwise until the solution turns from dark yellow to colorless to obtain sodium dibromide bromoaurate solution;

[0047] Preparation of core-satellite structure gold particles: Take 1ml of gold nanospheres wrapped in phospholipid bilayers (adjust the concentration to 1.0 at the maximum absorption wavelength), and add 100 μl of ascorbic acid (0.1M) and 100 μl of the above-mentioned dibromine Sodium bromi...

Embodiment 3

[0052] With 23nm gold spheres as the core and egg yolk lecithin as the linker, chloroauric acid in situ reduction is used to generate "satellite" gold nanoparticles, and the core-satellite structure gold nanoparticles are prepared:

[0053] (1) Preparation of 23nm gold sphere core: First, dissolve 50 μl of chloroauric acid (50 mM) in 4.95 ml of pure water, add 5 ml of hexadecyltrimethylammonium bromide (0.2 M), stir well, and At 27°C, add 600μl ice-cold (below 0°C) 0.01M sodium borohydride to react for 15min, and after standing for 3h, a gold seed solution is prepared; then, add 2ml cetyltrimethylammonium chloride (0.2M ), 1.5ml ascorbic acid (0.1M), and 50μl of the above gold seed solution were fully stirred and mixed, and 2ml of chloroauric acid (0.5mM) was added at 27°C for 15min. Trimethylammonium chloride (0.02M) to obtain a 10nm gold nuclei solution. Mix 40ml of cetyltrimethylammonium chloride (0.1M), 2.6ml of ascorbic acid (0.01M), and 2ml of the above-mentioned 10nm g...

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Abstract

The invention relates to the field of nanometer material science and analytical chemistry, in particular to a core-satellite structure gold nanoparticle and a preparation method thereof. The particleis composed of a three-layer structure, the inner layer takes a single gold nanosphere as a core, the middle layer is a phospholipid double-molecular layer wrapping the gold nanosphere, and the outermost layer is a plurality of "satellite" gold nanoparticles which are connected to the phospholipid double-molecular layer and surround the gold nanosphere core. The preparation method comprises the following steps: firstly, preparing a gold nanosphere core, then, wrapping the gold nanosphere with a liposome, and finally, reducing trivalent gold complexing ions or monovalent gold complexing ions byusing ascorbic acid and the "satellite" gold nanoparticle growing on the phospholipid double-molecular layer in situ. The preparation method of the core-satellite structure gold nanoparticle is simple and feasible, the morphology and the particle size of the product are controllable, and the stability and the dispersity are good. Due to the existence of hotspots between the gold cores and the "satellite" particles, the structure has good surface enhanced raman scattering (SERS) enhancing capability and has a potential application value in the field of analysis and determination.

Description

technical field [0001] The invention relates to the fields of nanomaterials and analytical chemistry, in particular to a core-satellite structure gold nano particle and a preparation method thereof. Background technique [0002] Surface-enhanced Raman scattering spectroscopy (SERS) means that when molecules are adsorbed or very close to a metal surface with a certain nanostructure, the Raman spectrum signal of a molecule is significantly enhanced. This phenomenon has been widely concerned by analytical chemists since it was discovered by Fleischmann et al. in 1974. SERS technology has the advantages of high selectivity, high sensitivity and fast nondestructive detection, and has shown important application potential in the fields of biochemical analysis, biomedical engineering, and environmental monitoring. [0003] Noble metal nanoparticles are Raman signal-enhancing substrates, and their structure and properties have a decisive impact on the SERS signal intensity. The st...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/65G01N21/658G01N2021/655G01N2021/656
Inventor 王运庆梅荣超陈令新
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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