Application of Injectable Hydrogel in Preparation of Vitreous Substitute
A technology for injecting water and vitreous body, which is applied in the field of injectable hydrogel and its preparation, can solve the problems of retinal hemorrhage, retinal detachment, affecting vision, etc., and achieve the effect of simple preparation method, simple operation process and strong practicability
Active Publication Date: 2021-06-18
TIANJIN UNIV
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Problems solved by technology
However, vitrectomy seriously affects vision and may cause additional diseases such as retinal detachment. Therefore, it is necessary to find a vitreous substitute to fill the vitreous cavity.
At present, the commonly used fillers include silicone oil, air, perfluorocarbon, etc., but these substitutes often permeate, not only cannot exist in the vitreous cavity for a long time, but also cause glaucoma, retinal hemorrhage and other diseases
Method used
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Embodiment Construction
[0027] The technical scheme of the present invention will be further described below in conjunction with specific examples.
[0028] In the examples, glycinamide hydrochloride and acryloyl chloride were used as raw materials according to references (Boustta M, Colombo P E, Lenglet S, et al. Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery [J]. Journal of Controlled Release, 2014,174:1-6) prepared a monomer acryloyl glycinamide with two amide groups, the chemical formula structure is shown in the following chemical formula:
[0029]
[0030] First, 6.3g of glycinamide hydrochloride, 6mL of deionized water, 33.6mL of 2mol / L potassium carbonate and 18mL of ether were mixed in a 100mL three-necked flask and ice-bathed. Then 5.7g of acryloyl chloride and 24mL of ether were mixed and slowly added dropwise into the three-necked flask, and the low-valence time was about 1 hour. After the dropwise addition was completed, the reaction was car...
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Abstract
The invention discloses the application of injectable hydrogel in the preparation of vitreous substitutes. N-acryloyl glycinamide and hydroxyethyl acrylamide with very good biocompatibility are used as reactants to form biocompatible hydrogels through free radical copolymerization. Very good injectable hydrogel. The gel has a relatively high swelling property when soaked in water. When the gel reaches a swelling equilibrium in water, the water content of the gel is as high as 98.5%, and it is completely transparent. After heating up, the gel can be injected through a needle and After curing, the injectable hydrogel of the present invention can be used as a vitreous substitute through experiments.
Description
technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to an injectable hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a three-dimensional network polymer with high water content. Hydrogels have good biocompatibility and other excellent properties, such as: environmental responsiveness, antibacterial, self-healing, superabsorbent, etc. These characteristics make hydrogels have broad application prospects in biomedicine, sensors, self-healing materials, and water retention and drought resistance. [0003] With the growth of age or the occurrence of some accidents, when people's eyes are traumatized, surgery is often required to remove the lesion. Among them, vitreous opacity and cataracts and other diseases account for a relatively large proportion, so the removal of the vitreous Surgery has also become a necessity. However, vitrectomy seriously affects vision and may ...
Claims
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IPC IPC(8): A61L27/16A61L27/50A61L27/52C08F222/38C08F220/58
CPCA61L27/16A61L27/50A61L27/52A61L2400/06A61L2430/16C08F220/58C08F222/385C08L33/24
Inventor 刘文广崔春燕
Owner TIANJIN UNIV