Nanoparticles, preparation method and application thereof and medicament
A nanoparticle and nanorod technology, applied in the field of nanoparticles, can solve the problems of low spatial resolution of photoacoustic imaging, high autofluorescence background, poor photothermal treatment effect, etc., achieve high spatial resolution, avoid abuse, improve The effect of photothermal therapy effect
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[0089] According to a second aspect of the present invention, there is provided a method for preparing the aforementioned nanoparticles, comprising the following steps:
[0090] Au / Ag nanorods are obtained by growing silver shells on the surface of gold nanorods.
[0091] The method for growing the silver shell layer can be carried out by using a conventional method for growing nanoparticles with a core-shell structure.
[0092] In one embodiment, the step of growing a silver shell layer on the surface of the gold nanorod comprises:
[0093] A surfactant solution, a silver source solution and a reducing agent solution are added to the gold nanorod-water dispersion liquid for mixed reaction to obtain Au / Ag nanorods.
[0094] The gold nanorod-water dispersion refers to a dispersion obtained by dispersing gold nanorods in water. The concentration of gold nanorods in the dispersion is, for example, 4 μg / mL, 5 μg / mL, 6 μg / mL, 7 μg / mL, 8 μg / mL, 9 μg / mL or 10 μg / mL.
[0095] A typ...
Embodiment approach
[0111] An exemplary embodiment, the preparation method of gold nanorods comprises the following steps:
[0112] (a) For every 0.1-20mL of 0.1-2mol / L gold source solution, add 0.1-20mL of 0.1-1mol / L surfactant solution and mix well; then, add 0.1-200μL of 0.1-2mol / L Mix the silver source solution evenly; add 0.1-2mL 0.1-2mol / L reducing agent solution after 60-3600min and mix evenly;
[0113] (b) Disperse the solution obtained in step (a) with a 1-1500W cell crushing device, add 0.1-200 μL of 0.1-2 mol / L fresh ice-cold reducing agent solution, and ultrasonically mix for 60 minutes after being treated by the cell crushing device for 1-10 minutes -3600min, to obtain gold nanorods.
[0114] It should be noted here that the above volumes are all relative amounts, for example, 0.1-20 mL of surfactant solution is added for every 0.1-20 mL of gold source solution.
[0115] The reducing agent in step (a) is ascorbic acid, and the reducing agent in step (b) is sodium borohydride.
[0...
Embodiment 1
[0166] A nanorod, the core is a gold nanorod with an aspect ratio of 4, and the shell is a 2nm thick silver shell.
[0167] A method for preparing nanorods, comprising the following steps:
[0168] (1) 0.17mL of 0.05M HAuCl 4 The solution was added into 20mL 0.1M CTAB solution, and stirred vigorously to mix the solution evenly, and the solution was bright brownish yellow. Then, 70 μL of 0.1M AgNO 3 Add dropwise to the above solution, and stir vigorously to mix the solution evenly. After 5 min, 0.12 mL of 0.1 M ascorbic acid solution was added, and the solution was mixed evenly with vigorous stirring, and the solution became colorless. Disperse the above solution with a 1500W cell disruptor, and immediately add 8 μL of 0.001M ice-cold NaBH 4 The aqueous solution was treated with a cell disruptor for 5 minutes and then stirred rapidly for 120 minutes. The solution turned purple, and the product Au NR was successfully prepared. Centrifuge the product at 13000rpm for 12min, d...
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