Preparation method of nattokinase microcapsules
A technology of nattokinase and microcapsules is applied in the field of preparation of nattokinase microcapsules, which can solve problems such as the reduction of bioavailability, achieve high bioavailability, prevent cardiovascular and cerebrovascular diseases, encapsulation efficiency and drug loading capacity good effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0037] Step 1), dissolving the freeze-dried sodium soybean powder in the ethanol solution, wherein the ratio of the freeze-dried natto powder to the ethanol solution is 1:1.5-1.8, and the ethanol solution is a 50wt% ethanol aqueous solution, and then add excipients The formulations are mixed evenly, and the microcapsule cores are obtained by a spheronizer, and dried for later use;
[0038] Wherein the excipient is formed by mixing microcrystalline cellulose, methylcellulose and gum arabic in a mass ratio of 1:1:1;
[0039] Step 2), uniformly disperse triethyl citrate, HPC, and talc in water, stir and add it to cellulose acetate to obtain a coating solution;
[0040] Among them, the mass ratio of triethyl citrate, HPC, talcum powder, water and cellulose acetate is 10:10:3:50:250;
[0041] Step 3), the pellets are poured into a fluidized bed coating machine, and sprayed into the coating solution to obtain nattokinase microcapsules.
[0042] Coating parameters are: fluidized be...
Embodiment 2
[0044] Step 1), dissolving the freeze-dried sodium soybean powder in the ethanol solution, wherein the ratio of the freeze-dried natto powder to the ethanol solution is 1:1.5-1.8, and the ethanol solution is a 50wt% ethanol aqueous solution, and then add excipients The formulations are mixed evenly, and the microcapsule cores are obtained by a spheronizer, and dried for later use;
[0045] Wherein the excipient is formed by mixing microcrystalline cellulose, methylcellulose and gum arabic in a mass ratio of 1:1:2;
[0046] Step 2), uniformly disperse triethyl citrate, HPC, and talc in water, stir and add it to cellulose acetate to obtain a coating solution;
[0047] Among them, the mass ratio of triethyl citrate, HPC, talcum powder, water and cellulose acetate is 10:10:3:50:250;
[0048] Step 3), the pellets are poured into a fluidized bed coating machine, and sprayed into the coating solution to obtain nattokinase microcapsules.
[0049] Coating parameters are: fluidized be...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com