Cell-penetrating peptide and preparation method and application thereof

A technology for solid-phase synthesis of membrane-penetrating peptides and polypeptides, applied in the biological field, can solve the problems of erythromycin being difficult to penetrate, and achieve the effects of easy production and promotion, mature technology, and expanded application range
CN109734780AActive Publication Date: 2019-05-10NANYANG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANYANG NORMAL UNIV
Publication Date
2019-05-10

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Abstract

The invention relates to the technical field of biology, in particular to a cell-penetrating peptide and a preparation method and application thereof. The amino acid sequence of the cell-penetrating peptide is Arg-Arg-Leu-Ser-Tyr-Thr-Lys-Lys-Lys-Trp-Trp-Pro. The cell-penetrating peptide is free of physiological toxicity and can be combined with erythrocin under the non-covalence effect, and the erythrocin is effectively mediated for penetrating a blood brain barrier.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a membrane-penetrating peptide and its preparation method and application. Background technique

[0002] Erythromycin is a macrolide antibiotic, which is effective against Gram-positive bacteria: Staphylococcus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus hemolyticus, Clostridium difficile, Bacillus diphtheriae, Bacillus anthracis has a strong inhibitory effect. The mechanism of action of erythromycin is to combine with the 50S subunit of ribonucleosomes of pathogenic bacteria, thereby inhibiting peptidyltransferase, and then affecting the translocation process of ribonucleosomes, inhibiting the synthesis of bacterial proteins, and achieving bacterial inhibition. Although erythromycin is the current first-line antibiotic, it is difficult to pass through the blood-brain barrier, which seriously affects its applicatio...

Claims

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