An effective antibacterial oral care solution

Abstract

The invention relates to an oral care solution capable of effectively inhibiting bacteria and a preparation method of the oral care solution. The oral care solution comprises a nano antibacterial factor and an adhesion enhancer; the nano antibacterial factor is a nano-encapsulated micelle particle of D-tryptophan and D-histidine prepared through a dialysis technology; the adhesion enhancer is a composition of hydroxypropyl cellulose, hyaluronic acid and glycerol. The stability of D-tryptophan and D-histidine is improved by adopting an amphiphilic polymer, mucosal penetration of D-tryptophan and D-histidine is promoted, release of D-tryptophan and D-histidine is slowed down, the release time is as long as 48 hours, and the biological membrane degradation effect of D-tryptophan and D-histidine is prolonged; the hydroxypropyl cellulose, the hyaluronic acid and the glycerol in the optimal proportion are selected to serve as the adhesion enhancer, the adhesion time of bacteriostatic factorsin the oral care solution on the surface of oral mucosa can be prolonged, the medicine utilization degree can be improved, the action time of the bacteriostatic factors in the oral cavity can be prolonged, and a better bacteriostatic effect is realized.

Description

technical field [0001] The application relates to the field of oral products, in particular to an oral care solution that enhances and prolongs the bacteriostatic effect of bacteriostatic factors. Background technique [0002] Many diseases in the human oral cavity are related to bacteria. For example, the imbalance of oral flora can easily lead to the occurrence of various oral diseases including dental caries, periodontitis and peri-implantitis. Caries is a multifactorial infectious disease. A large amount of evidence has shown that the presence of bacteria is a prerequisite for caries, and Streptococcus mutans is considered to be the main cariogenic bacteria, and the ability of Streptococcus mutans to form biofilm is stronger than that of other streptococci. Various studies have also confirmed that dental caries is closely related to dental plaque biofilm, and dental caries will not occur without dental plaque biofilm. The drug resistance of bacterial cells in biofilms ...

AI Technical Summary

Problems solved by technology

However, the dosage forms of adhesive administration are usually gel, coating, mucous membrane, etc., which are suitable for small and concentrated treatment areas, uneven drug concentrations in different parts of the oral cavity, and inconvenient application

[0004] CN104644478A discloses a bactericidal mouthwash with nursing and repairing effects. The ingredients of the mouthwash are as follows: bactericide, nursing and repairing ingredients, sweetener, humectant, essence, and the balance is deionized water. Since the mouthwash uses One or both of chlorhexidine gluconate, chlorhexidine acetate, and polyhexamethylene biguanide are used as fungicides, and long-term use will easily lead to tooth stain deposition, thus limiting its application

Since the antibacterial factor has a short contact time with the oral mucosa, its bactericidal and antibacterial effect needs to be improved