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A kind of medicinal device composition and preparation method thereof

A technology for a composition and a medicinal device, which is applied in the field of medicinal device composition and its preparation, can solve the problems that slow and controlled release preparations cannot achieve stable and uniform release, and achieve the effects of wide application range, low cost and convenient use.

Active Publication Date: 2022-05-20
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to provide a medical device composition to solve the problem that the existing sustained and controlled release preparations cannot achieve stable and uniform release for several days after administration

Method used

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  • A kind of medicinal device composition and preparation method thereof
  • A kind of medicinal device composition and preparation method thereof
  • A kind of medicinal device composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Add huperzine A to methanol and dissolve it into a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0053] Disperse the photocurable resin and PEG400 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of PEG400, and irradiate with a photocuring machine after the solvent is volatilized The resin layer was cured for 30 seconds.

[0054] The sample was placed in a shaker by direct release method for in vitro release test. In vitro release test measurement process: put the prepared medical device composition into a 100ml glass bottle, add 10ml of distilled water as the release medium, the temperature i...

Embodiment 2

[0056] Dissolve huperzine A in methanol to form a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0057] Disperse the photocurable resin and PVP K30 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of PVP K30. The machine irradiated the resin layer for 30 seconds to cure.

[0058] The sample was placed in a shaker by direct release method for in vitro release test. The determination process of the in vitro release test is the same as in Example 1.

Embodiment 3

[0060] Dissolve huperzine A in methanol to form a 250mg / ml solution. Use a 1ml syringe to transfer an appropriate amount of the mixture into a PVC cylinder mold and place it until the solvent evaporates. Avoid air bubbles during the operation. The cylinder mold has an outer diameter of 4.5 mm, height 3mm, each mold contains huperzine A powder 3mg.

[0061] Disperse the photocurable resin and Poloxamer 188 into the ethanol solution according to the mass ratio of 10:3, mix for 10 minutes, and then drop into the mold, so that each mold contains 24mg of photocurable resin and 7.2mg of Poloxamer 188. The machine irradiated the resin layer for 30 seconds to cure. The sample was placed in a shaker by direct release method for in vitro release test.

[0062] The sample was placed in a shaker by direct release method for in vitro release test. The determination process of the in vitro release test is the same as in Example 1.

[0063] Embodiment 1~3 in vitro release experiment gaine...

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Abstract

The invention provides a medical device composition and a preparation method thereof. The medical device composition includes a mold, a drug layer and a photocurable resin controlled release layer, and the drug layer and the photocured resin controlled release layer are arranged in the mold , and the photocurable resin controlled release layer is arranged on the outside of the drug layer; the drug layer includes an active drug, or a mixture of an active drug and an auxiliary material; the photocured resin controlled release layer includes a photocured resin and a porogen mixture, the mass ratio of the photocurable resin to the porogen is 0.5:1 to 100:1. The preparation method of the present invention is simple, operable, easy to use, and low in cost. The release rate of the drug can be flexibly adjusted by parameters such as the drug content, which is beneficial to realize the steady and slow release of the drug, realize the purpose of treatment and / or health care, and have a wide range of applications.

Description

technical field [0001] The invention relates to a composition, in particular to a medical device composition and a preparation method thereof. Background technique [0002] Compared with common formulations, the oral sustained-release drug delivery system has reduced the frequency of administration and can significantly increase patient compliance. Therefore, it has exerted great therapeutic advantages in the past few decades. In recent years, sustained-release pharmaceutical preparations have the characteristics of fewer administration times, less fluctuations in peak and valley blood drug concentrations, mild gastrointestinal irritation, long curative effect, and safety, which have attracted more and more clinical attention. With the wide application of materials and the in-depth study of drug delivery systems, the sustained and controlled release pharmaceutical preparations are increasing day by day, and the development and design of sustained and controlled release prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/10A61K47/32A61K31/4748A61K31/18
Inventor 胡连栋
Owner HEBEI UNIVERSITY