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Application of cobalt pyrophosphate nanomaterial to construction of nitric oxide electrochemical sensors

A technology of cobalt pyrophosphate nanometer and nitric oxide, which is applied in the direction of material electrochemical variables, nanotechnology, nanotechnology, etc., can solve the problems of high cost and unfavorable large-scale production and use, and achieve long cycle life and easy commercialization Application, effect of high specific surface area

Inactive Publication Date: 2019-07-23
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficient electrochemical detection of NO mostly relies on the use of noble metal materials, which is costly and unfavorable for large-scale production and use.

Method used

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  • Application of cobalt pyrophosphate nanomaterial to construction of nitric oxide electrochemical sensors
  • Application of cobalt pyrophosphate nanomaterial to construction of nitric oxide electrochemical sensors
  • Application of cobalt pyrophosphate nanomaterial to construction of nitric oxide electrochemical sensors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] To construct an electrochemical sensor for nitric oxide, assemble it as follows:

[0034] (1) Preparation of cobalt pyrophosphate nanomaterials

[0035] Mix the sodium pyrophosphate solution and the cobalt chloride solution to obtain a reaction solution. The molar ratio of sodium pyrophosphate and cobalt chloride in the reaction solution is 1.5. The reaction solution is stirred and reacted at 50°C for 10 hours and then heated at 8000r / min. Centrifuge at a speed of 10 min, take the precipitate, and use deionized water as the cleaning solution to centrifuge and wash the precipitate at a speed of 8000r / min, and then dry it at 60°C for 5 hours.

[0036] (2) Preparation of a working electrode coated with cobalt pyrophosphate nanomaterials

[0037] Disperse the cobalt pyrophosphate nanomaterial prepared in step (1) in deionized water at a ratio concentration of 3.3 mg / mL to obtain an electrode modification solution, and apply the electrode modification solution to a glassy c...

Embodiment 2

[0041] To construct an electrochemical sensor for nitric oxide, assemble it as follows:

[0042] (1) Preparation of cobalt pyrophosphate nanomaterials

[0043] Mix the sodium pyrophosphate solution and the cobalt acetate solution to obtain a reaction solution. The molar ratio of sodium pyrophosphate and cobalt acetate in the reaction solution is 1.7. Stir the reaction solution at 80°C for 12 hours and then react at a speed of 12000r / min. Centrifuge for 2 minutes, take the precipitate, use propanol as the cleaning solution, centrifuge and wash the precipitate at a speed of 12000r / min, and then dry it at 120°C for 0.5h;

[0044] (2) Preparation of a working electrode coated with cobalt pyrophosphate nanomaterials

[0045] Disperse the cobalt pyrophosphate nanomaterial prepared in step (1) in deionized water at a proportioning concentration of 5.0 mg / mL to obtain an electrode modification solution, and apply the electrode modification solution to a gold electrode, and heat Dry ...

Embodiment 3

[0049] To construct an electrochemical sensor for nitric oxide, assemble it as follows:

[0050] (1) Preparation of cobalt pyrophosphate nanomaterials

[0051] Mix potassium pyrophosphate solution and cobalt sulfate solution to obtain a reaction solution, the molar ratio of potassium pyrophosphate and cobalt sulfate in the reaction solution is 0.4, stir the reaction solution at 10°C for 16 hours and then at a speed of 3000r / min Centrifuge for 20 minutes, take the precipitate, use ethanol as the cleaning solution to centrifuge and wash the precipitate at a speed of 3000r / min, and then dry it at 30°C for 12 hours.

[0052] (2) Preparation of a working electrode coated with cobalt pyrophosphate nanomaterials

[0053]Disperse the cobalt pyrophosphate nanomaterial prepared in step (1) in deionized water at a proportioning concentration of 10 mg / mL to obtain an electrode modification solution, and apply the electrode modification solution to a screen-printed electrode at 20° C. Le...

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Abstract

The invention relates to an application of a cobalt pyrophosphate nanomaterial to construction of nitric oxide electrochemical sensors, and belongs to the technical field of electrochemical sensors. The cobalt pyrophosphate nanomaterial has a nanoscale to show a high specific surface area and an electrochemical activity of catalytic oxidation; the cobalt pyrophosphate nanomaterial is coated on electrodes to form working electrodes so as to construct NO electrochemical biosensors; and the sensors can be used for real-time detection of NO releasing of cells. The sensors show extremely low detection limit and high selectivity in practical detection, and are stable in electrochemical performance, relatively long recycling life and convenient for commercialized application.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensors, and in particular relates to the application of cobalt pyrophosphate nanomaterials in building an electrochemical sensor for nitric oxide. Background technique [0002] NO is a cell messenger molecule, which is produced by L-arginine and oxygen under the action of nitric oxide synthase (NOS), which can rapidly diffuse in the cell or cross the cell membrane to complete the task of the second messenger. Under normal concentration, it participates in the regulation of cell metabolism, proliferation, differentiation, apoptosis and other life activities, but when the concentration is too high, it will cause cell pathology, cause abnormal cell death, and lead to body diseases, among which it is related to the central nervous system, cardiovascular System, genitourinary system, gastrointestinal tract activity, immune process and other related lesions are often accompanied by the increase...

Claims

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Application Information

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IPC IPC(8): G01N27/26B82Y15/00B82Y30/00
CPCB82Y15/00B82Y30/00G01N27/26
Inventor 李长明张玉环梁滔滔邹卓
Owner SOUTHWEST UNIVERSITY
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