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Method for preparing bacterium insulation polylactic acid superfine nanofiber wound dressing

A technology of ultra-fine nano and wound dressings, applied in the direction of fiber chemical characteristics, pharmaceutical formula, single-component polyester rayon, etc., can solve the problems of large pores, difficult to block bacteria, etc., achieve high specific surface area, enhanced release, The effect of promoting liquid absorption

Inactive Publication Date: 2019-07-30
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method for bacteria-isolated polylactic acid ultrafine nanofiber wound dressings, which solves the problem that the wound dressings in the prior art have large pores and are difficult to block bacteria

Method used

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  • Method for preparing bacterium insulation polylactic acid superfine nanofiber wound dressing
  • Method for preparing bacterium insulation polylactic acid superfine nanofiber wound dressing
  • Method for preparing bacterium insulation polylactic acid superfine nanofiber wound dressing

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Effect test

Embodiment 1

[0037] A kind of preparation method of bacteria-isolated polylactic acid ultrafine nanofiber wound dressing of the present invention, specifically carries out according to the following steps:

[0038] Step 1. Mix chloroform and dimethyl sulfoxide at a mass ratio of 1:0.11 and use it as a solvent to dissolve three-armed polylactic acid with a fiber diameter of 10 nm to 100 nm to obtain a three-armed polylactic acid solution with a mass concentration of 8%.

[0039] Step 2. Add the three-arm polylactic acid solution into the electrospinning device. Under the conditions of a voltage of 10KV, a liquid propeller speed of 0.15mm / s, and a receiving distance of 5cm, the particle size range of 10nm to 100nm is prepared by the jet method. The three-arm polylactic acid microfiber.

Embodiment 2

[0041] A kind of preparation method of bacteria-isolated polylactic acid ultrafine nanofiber wound dressing of the present invention, specifically carries out according to the following steps:

[0042] Step 1. Mix chloroform and dimethyl sulfoxide at a mass ratio of 1:0.25 and use it as a solvent to dissolve three-armed polylactic acid with a fiber diameter of 10 nm to 100 nm to obtain a three-armed polylactic acid solution with a mass concentration of 15%.

[0043] Step 2. Add the three-arm polylactic acid solution into the electrospinning device. Under the conditions of a voltage of 20KV, a liquid propeller speed of 0.18mm / s, and a receiving distance of 10cm, the jet method is used to prepare a particle size range of 10-100nm The three-arm polylactic acid microfiber.

Embodiment 3

[0045] A kind of preparation method of bacteria-isolated polylactic acid ultrafine nanofiber wound dressing of the present invention, specifically carries out according to the following steps:

[0046] Step 1. Mix chloroform and dimethyl sulfoxide at a mass ratio of 1:0.18 and use it as a solvent to dissolve three-armed polylactic acid with a fiber diameter of 10 nm to 100 nm to obtain a three-armed polylactic acid solution with a mass concentration of 15%.

[0047] Step 2. Add the three-arm polylactic acid solution into the electrospinning device, and use the jet method to prepare a particle size range of 10-100nm under the conditions of a voltage of 15KV, a liquid propeller speed of 0.2mm / s, and a receiving distance of 8cm. The three-arm polylactic acid microfiber.

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Abstract

The invention discloses a method for preparing a bacterium insulation polylactic acid superfine nanofiber wound dressing. The method specifically comprises the following steps: 1, dissolving polylactic acid with chloroform and dimethyl sulfoxide as solvents, and preparing a solution of which the polylactic acid concentration is as shown in the specification; 2, putting the polylactic acid solutioninto an electrostatic spinning device, and preparing a polylactic acid superfine fiber by using a jet flow method, that is, the bacterium insulation polylactic acid superfine nanofiber wound dressing. The fiber aperture of the bacterium insulation polylactic acid superfine nanofiber wound dressing prepared by using the method disclosed by the invention is smaller than the diameter of a bacterium,and the functions of bacterium insulation and infection prevention can be effectively achieved; in addition, because of porous small gaps in the polylactic acid superfine fiber, hemostasis can be promoted, because of a high specific surface area, liquid absorption can be promoted, the release of medicines or antibiotics can be enhanced, and the wound healing can be promoted while inevitable secondary damage caused when a conventional dressing is replaced is eliminated.

Description

technical field [0001] The invention belongs to the technical field of medical nanomaterials, and in particular relates to a preparation method of a bacterial-isolated polylactic acid ultrafine nanofiber wound dressing. Background technique [0002] Wound dressings are used to prevent microbial penetration and to maintain wound moisture balance and gas exchange. As a polymer with excellent biocompatibility, polylactic acid has extremely low toxicity in the body. It is a type of wound dressing material widely used in the field of modern biomedicine. The electrospun fiber membrane of polylactic acid prepared by electrospinning technology is in the form of The wound dressing has a large specific surface area and porosity, and can imitate the extracellular matrix on the basis of traditional dressings to promote wound healing. Therefore, the electrospun fiber membrane of polylactic acid prepared by electrospinning technology has a high porosity. , small mass, good flexibility, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/62A61L15/26A61L15/42A61L15/44A61L15/46A61L15/64
CPCA61L15/26A61L15/42A61L15/44A61L15/46A61L15/64A61L2300/404A61L2300/412A61L2400/04A61L2400/12D01F6/625C08L67/04
Inventor 沈文敖芬宁远兰张越杨蓉蓉
Owner SHAANXI UNIV OF SCI & TECH
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