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Macromolecular micro-particle and preparation and application thereof

A technology of macromolecules and microparticles, applied in the field of macromolecular microparticles doped with unsaturated double bonds of iodine, can solve the problems of cell damage and high cost, and achieve the effects of promoting growth, low production cost and low cytotoxicity

Inactive Publication Date: 2019-08-13
RENMIN UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Their problems are: high cost, long-term toxicity of inorganic heavy metals in the body has become a potential hidden danger; delicate cells and tenacious bacteria also have negatively charged biofilms, quaternary ammonium salts and other cationic sterilization The agent kills bacteria based on the interaction of positive and negative charges, and at the same time causes irreversible damage to cells

Method used

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  • Macromolecular micro-particle and preparation and application thereof
  • Macromolecular micro-particle and preparation and application thereof
  • Macromolecular micro-particle and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1, preparation contains the macromolecule particle of double bond

[0057] The microparticles are prepared from the following raw materials: trans polyisoprene, toluene, water, polyvinyl alcohol;

[0058] The preparation method comprises the following steps: dissolving trans-polyisoprene in toluene at 2% mass volume percentage, stirring at room temperature overnight at 1500 r / min, to obtain an oil phase;

[0059] Take polyvinyl alcohol and dissolve it in water at 0.5% mass volume percentage, that is, dissolve 0.5g polyvinyl alcohol in 100mL deionized water, and stir at room temperature overnight at 1500r / min to obtain an aqueous phase;

[0060] Add 9 parts of the water phase and 1 part of the oil phase, close the container, ultrasonically disperse for 2 hours, then open the container, and remove the organic solvent in the system by ultrasonic volatilization for 4 hours at 55°C to obtain a water dispersion of polymer microparticles (high The concentration of ...

Embodiment 2

[0065] Example 2, preparation of polymer microparticles containing double bonds

[0066] The microparticles are prepared from the following raw materials: cis-polyisoprene, toluene, water, and polyvinyl alcohol;

[0067] The preparation method comprises the following steps: dissolving cis-polyisoprene in toluene at a mass volume percentage of 2%, stirring at room temperature overnight at 1500 r / min, to obtain an oil phase;

[0068] Take polyvinyl alcohol and dissolve it in deionized water at 2% mass volume percentage, stir overnight at room temperature at 1500r / min to obtain the water phase; add 9 parts of the water phase and 1 part of the oil phase, seal the container, and ultrasonically disperse for 2 hours , then open the container, and under the condition of 55°C, ultrasonically volatilize for 4 hours to remove the organic solvent, and obtain the aqueous dispersion of polymer microparticles;

[0069] The difference from the above-mentioned Example 1 is that the double bon...

Embodiment 3

[0070] Example 3, preparation of polymer microparticles containing double bonds

[0071] The microparticles are prepared from the following raw materials: trans polyisoprene, toluene, water, polyvinyl alcohol;

[0072] The preparation method comprises the following steps: dissolving trans-polyisoprene in toluene at 2% mass volume percentage, stirring at room temperature overnight at 1500 r / min, to obtain an oil phase;

[0073] Sodium lauryl sulfate was dissolved in deionized water at 0.5% mass volume percentage, and stirred at room temperature overnight at 1500 r / min to obtain an aqueous phase;

[0074] Add 9 parts of the water phase and 1 part of the oil phase, close the container, ultrasonically disperse for 2 hours, then open the container, and remove the organic solvent by ultrasonic volatilization for 4 hours under the condition of 65°C to obtain a water dispersion of polymer particles;

[0075] The difference from the above-mentioned Example 1 is that the surfactant is ...

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Abstract

The invention provides a macromolecular micro-particle and preparation and application thereof. The macromolecular micro-particle is a macromolecular micro-particle which is doped with iodine and contains double bonds. According to the macromolecular micro-particle which is doped with iodine and contains the double bonds, the release amount of iodine at a practical action part is controllable, sothat long-time slow release is achieved; the macromolecular micro-particle shows significant antibacterial activity in escherichia coli tests, has extremely low cytotoxicity and accordingly can play arole of sterilization at the concentration of practical use and also ensure that the cytotoxicity is 90% or above; the macromolecular micro-particle is nonirritant and cannot cause unnecessary delayed wound healing. The macromolecular micro-particle can slowly release iodine for a long time; in mouse back wound healing experiments, the macromolecular micro-particle promotes expression of proteinsignals for repairing and proliferation in cells and then significantly promotes growth of the cells, so that the cell survival rate is increased, and wound healing is accelerated. A preparation technology of the macromolecular micro-particle which is doped with iodine and contains the double bonds is simple, the macromolecular micro-particle is low in production cost and good in stability, and the repetition rate is high.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to an iodine-doped unsaturated double-bond macromolecule microparticle which is antibacterial and can promote wound healing, as well as its preparation and application. The iodine-doped unsaturated double-bond macromolecular microparticles have excellent antibacterial and anti-infection effects while promoting wound healing. Background technique [0002] The skin is the largest organ of the human body. It is in direct contact with the external environment, helps the human body moisturize and resist external risks, and is the first barrier of the human body. Large-scale damage to the skin will lead to the loss of body protein and water, immune system imbalance, and life-threatening. In order to reduce as much as possible the persistent difficulty of skin healing, skin infection, and death caused by burns, large-area trauma, or diseases such as diabetes, disinfectants are widely used in the ...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/69A61K9/10A61P17/02A61P31/02A61P31/04
CPCA61K9/10A61K33/18A61K47/6933A61P17/02A61P31/02A61P31/04Y02A50/30
Inventor 王亚培李睿婷王震
Owner RENMIN UNIVERSITY OF CHINA
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