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A surface-modified decellularized biological tissue material and its preparation method and application

A biological tissue and surface modification technology, applied in pharmaceutical formulations, drug delivery, pharmaceutical sciences, etc., can solve problems such as adverse reactions, infected intestinal adhesions, and reduce isolation effects, reducing immunogenicity, solving source shortages, and preparing methods. simple effect

Inactive Publication Date: 2020-11-06
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the course of clinical use, hyaluronic acid has the effect of obviously preventing adhesions, but it can cause serious adverse reactions during use, including abdominal pain and abdominal infection and intestinal adhesions
At the same time, absorbable hyaluronic acid preparations will also undergo dissociation in the body during use, thereby reducing its isolation effect

Method used

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  • A surface-modified decellularized biological tissue material and its preparation method and application
  • A surface-modified decellularized biological tissue material and its preparation method and application
  • A surface-modified decellularized biological tissue material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Use a vacuum desiccator as the reaction environment for fluorination modification, open the upper hemisphere of the vacuum desiccator, and apply high-vacuum silicone grease on the frosted surfaces of the upper and lower hemispheres for sealing. Under the ceramic partition inside the lower hemisphere, blue silica gel is placed to absorb water vapor and roughly show the humidity inside the vacuum desiccator. Use a 1000 µl pipette to pipette 200 µl of FDTS into a 20 mL vial and place the open bottle in the center of the ceramic septum. Place the dried decellularized porcine jugular vein around the ceramic separator. Cover the upper hemisphere of the vacuum desiccator, and pump the pressure inside the vacuum desiccator through the vacuum pump for 5 seconds every 30 minutes, for a total of 5-10 times, so that the final pressure in the vacuum desiccator is not higher than 10kPa. After 24 hours, vapor deposition was complete. The decellularized porcine jugular vein modified ...

Embodiment 2

[0073] On the basis of Example 1, before drawing FDTS to the 20 ml sample bottle, add 15 ml of xylene in the sample bottle, add 200 microliters of FDTS under the liquid level of xylene and cover and shake well, Then open the mouth of the bottle and place it in the center of the ceramic partition. During the fluorination modification process, keep the vacuum desiccator at 30°C by adjusting the distance between the infrared heating lamp and the vacuum desiccator.

[0074] The fluorination modification method used in this example is a vapor phase deposition method, which uses the fluorination reagent to easily volatilize to form a gaseous substance, so that the fluorination reagent is transferred to the surface of the decellularized biological material that needs to be surface modified. Afterwards, the fluorinating reagent reacts chemically with the surface of the decellularized biological material, so that the surface of the decellularized biological material undergoes fluorinat...

Embodiment 3

[0083] On the basis of Example 1, the surface of the decellularized porcine jugular vein was pretreated. The pretreatment includes freezing the decellularized porcine jugular vein and drying it with a freeze dryer to remove water; using a low-temperature plasma generator to conduct plasma treatment on the decellularized porcine jugular vein after drying. The plasma discharge gas source used is for air.

[0084] Performance measurements were performed on the surface-modified decellularized biological tissue material prepared in Example 3 above.

[0085] 1. Surface element composition of surface-modified decellularized biological tissue materials

[0086] In order to detect the surface modification effect of the prepared materials, corresponding XPS elemental analysis tests were carried out on the modified decellularized biological tissue materials. The XPS elemental analysis test shows that the surface atomic composition ratio of the modified product is: C: 47.36%, F: 32.56%,...

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Abstract

The invention relates to a surface-modified acellular biological tissue material and a preparation method and application thereof. The surface-modified acellular biological tissue material having excellent bioadhesion resistance and similar mechanical properties to biological tissues is prepared by modifying at least one surface of an acellular biological material via a silane coupling agent or acyl chloride coupling agent having high chlorine content. The surface-modified acellular biological tissue material is applicable as a material to prevent bioadhesion, resist thrombosis and resist biocontamination; after further modifications are made, the material is suitable for lubricating tissues and organs to resist abrasion. Compared with the prior art, the surface-modified acellular biological tissue material which is a biological inert material has good bio-inertia, is non-absorbable and is very practical.

Description

technical field [0001] The invention relates to a biological tissue material, in particular to a surface-modified decellularized biological tissue material and a preparation method and application thereof. Background technique [0002] With the development of population aging, coronary heart disease has become a serious public health problem, which has caused serious obstacles to the healthy development of society and economy in our country. In the surgical treatment of coronary heart disease, coronary artery bypass grafting is a more ideal and effective treatment than coronary interventional surgery. Coronary artery bypass grafting requires the use of bypass vessels in order to bypass some or all of the blood flow in the narrowed area of ​​​​the coronary artery and supply it to the distal end of the ischemic heart. The selection of artificial small blood vessels as bypass vessels can avoid multiple operations on patients with autologous blood vessels before surgery, greatl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/50A61L31/00A61L31/14
CPCA61L27/3604A61L27/3687A61L27/50A61L27/507A61L31/005A61L31/14A61L2400/10A61L2400/18
Inventor 孙宋暄赵鑫张诗宜
Owner SHANGHAI JIAOTONG UNIV
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