Composition comprising stem cell-derived exosome for reducing wrinkles and cosmetic

An exosome and stem cell technology, applied in cosmetics, cosmetic preparations, cosmetic preparations, etc., to prevent skin photoaging, good effect, wrinkle reduction and anti-aging effect

Inactive Publication Date: 2019-08-23
广州远想生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant research on the anti-wrinkle and anti-aging effects of adipose-derived mesenchymal stem cell exosomes

Method used

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  • Composition comprising stem cell-derived exosome for reducing wrinkles and cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This example is an eye cream for improving wrinkles, which contains the following components in percentage by weight: 0.5% of fat-derived mesenchymal stem cell exosomes, 0.1% of Rhodiola rosea extract, and 0.2% of Centella asiatica extract , Lupine Extract 0.2%, Propylene Glycol 5%, Glycerin 1.6%, Glyceryl Stearate 1%, PEG-20 Methyl Glucose Sesquistearate 0.3%, White Mineral Oil 10.2%, Polydimethyl Siloxane 2.3%, Ammonium Acryloyldimethyltaurate / VP Copolymer 0.5%, Carbomer 0.5%, Xanthan Gum 0.05%, Cetyl Stearyl Alcohol 1.8%, Phenoxyethanol 0.4%, Hydroxy Benzyl 0.1%, propylparaben 0.1% and the balance of deionized water.

[0029] The preparation method of the eye cream for improving wrinkles described in this embodiment comprises the following steps:

[0030] 1. Add glycerol stearate, PEG-20 methylglucose sesquistearate, white mineral oil, polydimethylsiloxane, methylparaben and propylparaben into the oil phase pot in sequence , heating and stirring to raise the temper...

Embodiment 2

[0038]1. Elastase inhibitory activity

[0039] By measuring the amount of 4-nitroanilide (4-nitoanilide) peptide produced by the action of pancreatic elastase on the substrate N-succinyl-alanine-alanine-alanine-p-nitroaniline, using spectrophotometry Elastase activity was assessed. N-succinyl-alanine-alanine-alanine-p-nitroaniline (Sigma) and other substances for the test were incubated at 37°C and the reaction was initiated by adding porcine pancreatic elastase. The absorbance at a wavelength of 410 nm was measured to measure the amount of free 4-nitroaniline released. 0.2M Tris-HCl buffer solution with a pH of 8.0 was used as a negative control, and the test groups and test results are shown in Table 1.

[0040] Table 1 Elastase activity test results

[0041]

[0042] It can be seen from the percentage of elastase inhibition in Table 1 that it is the percentage of the relative negative control, adipose-derived mesenchymal stem cell exosomes have a dose-dependent inhibi...

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PUM

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Abstract

The invention discloses a composition comprising a stem cell-derived exosome for reducing wrinkles. The composition also comprises a fat-derived mesenchymal stem cell exosome and a plant extract. According to the composition, the fat-derived mesenchymal stem cell exosome is added into the composition, has the activity of inhibiting elastase and collagenase, can effectively resist aging, improve the elasticity of the skin and reduce skin wrinkles, and can further promote the absorption of the plant extract to a certain extent, so that the utilization rate of the plant extract in the skin is higher. The invention also discloses a cosmetic comprising the composition comprising the stem cell-derived exosome for reducing wrinkles.

Description

technical field [0001] The present invention relates to stem cell exosomes and uses thereof, in particular to a composition and cosmetics containing stem cell-derived exosomes for improving wrinkles. Background technique [0002] Exosomes are a kind of membranous vesicles released from the intracellular vesicle structure to the outside of the cell, with a diameter of about 30-150nm. Cells will secrete exosomes under normal physiological conditions. Due to the plasma membrane and multivesicular As a result of fusion between bodies, exosome-like vesicles are secreted into the extracellular space through exocytosis. Exosome-like vesicles are divided into interior and exterior by a lipid bilayer, and because they contain membrane lipids, membrane proteins, genetic material, and cytoplasmic components, they indirectly reflect the nature and state of cells. At the same time, exosome-like vesicles mediate cell-cell communication by binding to other cells and tissues and transferri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/98A61K8/9789A61Q19/00A61Q19/08
CPCA61K8/981A61K8/99A61K2800/782A61Q19/00A61Q19/08A61K8/9789
Inventor 陈玉容樊鸿浩
Owner 广州远想生物科技股份有限公司
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