Medicine materials for ketoprofen pasters and preparation method of medicine materials

A technology of ketoprofen and patch, which is applied in the direction of medical formula, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problem of less solid loading of active ingredient ketoprofen and poor slow-release effect. Good, short drug effect time, etc., to meet the needs of clinical treatment, good application prospects, and long drug effect time
CN110179770APending Publication Date: 2019-08-30GUIZHOU LIANSHENG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUIZHOU LIANSHENG PHARMA
Publication Date
2019-08-30

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Abstract

The invention discloses medicine materials for ketoprofen pasters. The medicine materials comprise the following components in parts by weight of 5-10 parts of ketoprofen, 2-6 parts of polyethylene glycol, 1-2 parts of polyvinyl alcohol, 2-4 parts of carboxymethyl chitosan, 2-4 parts of laurocapram, 1-2 parts of oleic acid and 20-24 parts of melt adhesive. A semi-interpenetrating network structureformed from the carboxymethyl chitosan, the polyethylene glycol and the polyvinyl alcohol is used as a substrate framework, and the laurocapram and the oleic acid are used as composite accelerants, so that the diffusion resistance of the ketoprofen is improved, the slow release effects of the ketoprofen are promoted, and disease pain can be continuously alleviated; and besides, loading and retention of the ketoprofen as an effective component are increased, the transdermal absorption efficiency of the ketoprofen is improved, the medicine effects can be continuously transdermal within 24h, themedicine effects are effectively improved, and the pain alleviating effects are strengthened. The preparation technology is simple, the raw materials are simple, the biocompatibility is good, the cost is low, the stability is good, industrial production is easy, and clinical treatment needs can be met.
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Description

technical field

[0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicinal material for ketoprofen patch and a preparation method thereof. Background technique

[0002] The chemical name of ketoprofen is α-methyl-3-benzoyl-phenylacetic acid (C16H14O3), and its molecular weight is 254.29. Ketoprofen mainly reversibly inhibits the activity of cyclooxygenase (COXs) pro-inflammatory peptides and / or lipoxygenases (LOXs), thereby inhibiting the prostaglandins (PGs), leukotrienes (LTs) and thrombosis The biosynthesis of bradykinin (TXs) reduces the release of bradykinin, and then exerts its good antipyretic, analgesic and anti-inflammatory effects, and also has a certain inhibitory effect on the adhesion and aggregation of platelets, and is widely used in clinical treatment. All kinds of rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis pain, rheumatoid arthritis, dysmenorrhea, toothache, posto...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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