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Medicine materials for ketoprofen pasters and preparation method of medicine materials

A technology of ketoprofen and patch, which is applied in the direction of medical formula, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve the problem of less solid loading of active ingredient ketoprofen and poor slow-release effect. Good, short drug effect time, etc., to meet the needs of clinical treatment, good application prospects, and long drug effect time

Pending Publication Date: 2019-08-30
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For above-mentioned deficiencies in the prior art, the object of the present invention is to provide a kind of medicinal material and preparation method thereof for ketoprofen patch, solve existing ketoprofen patch and exist slow-release effect not good, active ingredient ketoprofen The immobilized amount of fen is small, resulting in short drug effect time and poor stability

Method used

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  • Medicine materials for ketoprofen pasters and preparation method of medicine materials
  • Medicine materials for ketoprofen pasters and preparation method of medicine materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1) Weigh the following components in parts by weight: 5 parts of ketoprofen, 2 parts of polyethylene glycol, 1 part of polyvinyl alcohol, 2 parts of carboxymethyl chitosan, 2 parts of lauryl azone, 1 part of oleic acid 20 parts and hot melt adhesive;

[0023] 2) Stir and dissolve carboxymethyl chitosan, polyethylene glycol, polyvinyl alcohol and oleic acid evenly, then slowly add ketoprofen and laurocaprazine, stir and dissolve evenly to obtain a mixed solution, and then mix the The mixed solution was placed at 110°C, reacted for 2.0h, and stirred at 8000rpm for 60min to make it evenly mixed until no particles were visible to the naked eye. After cooling to room temperature, it was sterilized by filtration with a 0.22μm ultrafiltration membrane to obtain solution I;

[0024] 3) Put the hot melt adhesive into the melter, heat it to 120°C for 2.0 hours, and melt the glue block into a milky white paste;

[0025] 4) Transfer the melted hot melt adhesive in step 3) from the...

Embodiment 2

[0027] 1) Weigh the following components in parts by weight: 8 parts of ketoprofen, 4 parts of polyethylene glycol, 1 part of polyvinyl alcohol, 3 parts of carboxymethyl chitosan, 3 parts of lauryl azone, 2 parts of oleic acid 23 parts and hot melt adhesive;

[0028] 2) Stir and dissolve carboxymethyl chitosan, polyethylene glycol, polyvinyl alcohol and oleic acid evenly, then slowly add ketoprofen and laurocaprazine, stir and dissolve evenly to obtain a mixed solution, and then mix the The mixed solution was placed at 120°C, reacted for 1.5h, and stirred at 10,000rpm for 30min to make it evenly mixed until no particles were visible to the naked eye. After cooling to room temperature, filter and sterilize with a 0.22μm ultrafiltration membrane to obtain solution I;

[0029] 3) Put the hot melt adhesive into the melter, heat it to 125°C for 2.0 hours, and melt the glue block into a milky white paste;

[0030] 4) Transfer the melted hot melt adhesive in step 3) from the melt ma...

Embodiment 3

[0032] 1) Weigh the following components in parts by weight: 10 parts of ketoprofen, 6 parts of polyethylene glycol, 4 parts of carboxymethyl chitosan, 1 part of polyvinyl alcohol, 4 parts of laurocaprine, 2 parts of oleic acid 24 parts and hot melt adhesive;

[0033] 2) Stir and dissolve carboxymethyl chitosan, polyethylene glycol, polyvinyl alcohol and oleic acid evenly, then slowly add ketoprofen and laurocaprazine, stir and dissolve evenly to obtain a mixed solution, and then mix the The mixed solution was placed at 130°C, reacted for 1.5h, and stirred at 9000rpm for 40min to make it evenly mixed until no particles were visible to the naked eye. After cooling to room temperature, it was sterilized by filtration with a 0.22μm ultrafiltration membrane to obtain solution I;

[0034] 3) Put the hot melt adhesive into the melter, heat it to 140°C for 1.5 hours, and melt the glue block into a milky white paste;

[0035] 4) Transfer the melted hot melt adhesive in step 3) from t...

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Abstract

The invention discloses medicine materials for ketoprofen pasters. The medicine materials comprise the following components in parts by weight of 5-10 parts of ketoprofen, 2-6 parts of polyethylene glycol, 1-2 parts of polyvinyl alcohol, 2-4 parts of carboxymethyl chitosan, 2-4 parts of laurocapram, 1-2 parts of oleic acid and 20-24 parts of melt adhesive. A semi-interpenetrating network structureformed from the carboxymethyl chitosan, the polyethylene glycol and the polyvinyl alcohol is used as a substrate framework, and the laurocapram and the oleic acid are used as composite accelerants, so that the diffusion resistance of the ketoprofen is improved, the slow release effects of the ketoprofen are promoted, and disease pain can be continuously alleviated; and besides, loading and retention of the ketoprofen as an effective component are increased, the transdermal absorption efficiency of the ketoprofen is improved, the medicine effects can be continuously transdermal within 24h, themedicine effects are effectively improved, and the pain alleviating effects are strengthened. The preparation technology is simple, the raw materials are simple, the biocompatibility is good, the cost is low, the stability is good, industrial production is easy, and clinical treatment needs can be met.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicinal material for ketoprofen patch and a preparation method thereof. Background technique [0002] The chemical name of ketoprofen is α-methyl-3-benzoyl-phenylacetic acid (C16H14O3), and its molecular weight is 254.29. Ketoprofen mainly reversibly inhibits the activity of cyclooxygenase (COXs) pro-inflammatory peptides and / or lipoxygenases (LOXs), thereby inhibiting the prostaglandins (PGs), leukotrienes (LTs) and thrombosis The biosynthesis of bradykinin (TXs) reduces the release of bradykinin, and then exerts its good antipyretic, analgesic and anti-inflammatory effects, and also has a certain inhibitory effect on the adhesion and aggregation of platelets, and is widely used in clinical treatment. All kinds of rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis pain, rheumatoid arthritis, dysmenorrhea, toothache, posto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/36A61K47/10A61K47/32A61K47/22A61K47/12A61K31/192A61P29/00
CPCA61K9/7023A61K31/192A61K47/10A61K47/12A61K47/22A61K47/32A61K47/36A61P29/00
Inventor 杜平聂安军吕文俊贺颖
Owner GUIZHOU LIANSHENG PHARMA
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