Calcium and vitamin D chewable tablet

A vitamin and chewable tablet technology, which is used in medical preparations with non-active ingredients, pill delivery, metabolic diseases, etc., can solve the problems of high requirements for gastric acid quality and secretion quantity, low bioavailability, and increased gastric burden, etc. Improved bioavailability, good fluidity, and beneficial effects on absorption

Inactive Publication Date: 2019-09-06
BRAVEIY BIOTECHNOLOGY (ANHUI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, domestic calcium and vitamin D chewable tablets mostly use inorganic calcium such as calcium carbonate and calcium hydrogen phosphate as the calcium source, which is not easy to dissolve. After interacting with gastric acid in the stomach, the calcium is released into an ionic state before it can be absorbed in the body, and the bioavailability is low. , and have very high requirements on the quality and secretion of gastric acid. Supplementing calcium carbonate in the case of insufficient gastric acid or people with stomach problems will increase the burden on the stomach, and even cause constipation in severe cases.

Method used

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  • Calcium and vitamin D chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Calcium Vitamin D Chewable Tablet Formula (Table 1)

[0031] Table 1

[0032]

[0033] 2. Preparation method:

[0034] (1) Weighing: The above materials are weighed according to the prescription in Table 1 for use;

[0035] (2) Pretreatment: All materials need to be passed through 80 mesh sieve for use;

[0036] (3) Wet granulation: add the prescribed amount of calcium citrate, together with D-mannitol and milk powder, into the wet granulator, set the stirring speed to 200~300r / min, the granulating knife 500~1000r / min, Pre-mix for 2~5min, add 120g of purified water, continue to stir for 5~10min, observe the condition of soft material, then set the sizing knife speed to 800~1000r / min, use the No. 2 screen for wet sizing to obtain the wet Granules; if the micronized calcium citrate is electrostatically charged, add a small amount of magnesium stearate for treatment.

[0037] (4) Drying: Put the above-mentioned wet granules into the boiling granulating dryer, set the drying temp...

Embodiment 2

[0045] 1. Calcium vitamin D chewable tablet formula (table 2)

[0046] Table 2

[0047] Composition Weight (g) Calcium Citrate437.5 Vitamin D 2 100,000 IU / g

0.78 Sorbitol200 Isomalt243.7 Milk powder100 Strawberry flavor8 Beet red0.02 Silica5 Magnesium stearate 5

[0048] 2. Preparation method:

[0049] The preparation method of this example is the same as that of example 1, in which "Isomalt" is used instead of "D-mannitol", "strawberry flavor" is used instead of "sweet orange flavor", and "beet red" is substituted for "sunset yellow". Aluminum Lake".

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Abstract

The invention discloses a calcium and vitamin D chewable tablet. The calcium and vitamin D chewable tablet is prepared from, by weight, 43.75% of micronized calcium citrate, 0.08% of vitamin D2 100,000IU/g, 0.80% of edible essence, 0.02% of colorings, 0.50% of silicon dioxide, 0.50% of magnesium stearate and the balance filler. By selection of organic calcium namely calcium citrate (micronized into 800-mesh powder) as a calcium source, absorption is benefited, bioavailability is improved, sweet and delicate taste is achieved, and the chewable tablet can be beneficially accepted by consumers. By selection of purified water as a wetting agent in preparation, low cost is realized, prepared particles are uniform in size and excellent in formability and fluidity, and product quality stability is guaranteed.

Description

Technical field [0001] The invention relates to a calcium and vitamin D chewable tablet which has no irritation to the stomach and intestines and is easily absorbed. Background technique [0002] Calcium is necessary to maintain the normal function of human nerves, muscles, skeletal system, cell membranes and capillary permeability. Vitamin D can participate in the metabolism of calcium and phosphorus, promote their absorption and play an important role in bone formation. Calcium Vitamin D Chewable Tablet is a compound preparation containing calcium and vitamin D. It can be used as a calcium supplement for pregnant and lactating women, menopausal women, the elderly, children, etc., and helps prevent osteoporosis. [0003] At present, domestic calcium and vitamin D chewable tablets mostly use inorganic calcium such as calcium carbonate and calcium hydrogen phosphate as calcium sources, which are not easy to dissolve. After interacting with gastric acid in the stomach, the calcium i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/04A61K47/12A61K31/194A61K31/592A61P19/10A61P3/02
CPCA61K9/0056A61K9/2009A61K9/2013A61K31/194A61K31/592A61P19/10A61P3/02A61K2300/00
Inventor 陈国靖陈斌蔡家昌程一林
Owner BRAVEIY BIOTECHNOLOGY (ANHUI) CO LTD
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