Calcium and vitamin D chewable tablet
A vitamin and chewable tablet technology, which is used in medical preparations with non-active ingredients, pill delivery, metabolic diseases, etc., can solve the problems of high requirements for gastric acid quality and secretion quantity, low bioavailability, and increased gastric burden, etc. Improved bioavailability, good fluidity, and beneficial effects on absorption
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Embodiment 1
[0030] 1. Calcium Vitamin D Chewable Tablet Formula (Table 1)
[0031] Table 1
[0032]
[0033] 2. Preparation method:
[0034] (1) Weighing: The above materials are weighed according to the prescription in Table 1 for use;
[0035] (2) Pretreatment: All materials need to be passed through 80 mesh sieve for use;
[0036] (3) Wet granulation: add the prescribed amount of calcium citrate, together with D-mannitol and milk powder, into the wet granulator, set the stirring speed to 200~300r / min, the granulating knife 500~1000r / min, Pre-mix for 2~5min, add 120g of purified water, continue to stir for 5~10min, observe the condition of soft material, then set the sizing knife speed to 800~1000r / min, use the No. 2 screen for wet sizing to obtain the wet Granules; if the micronized calcium citrate is electrostatically charged, add a small amount of magnesium stearate for treatment.
[0037] (4) Drying: Put the above-mentioned wet granules into the boiling granulating dryer, set the drying temp...
Embodiment 2
[0045] 1. Calcium vitamin D chewable tablet formula (table 2)
[0046] Table 2
[0047] Composition Weight (g) Calcium Citrate437.5 Vitamin D 2 100,000 IU / g
0.78 Sorbitol200 Isomalt243.7 Milk powder100 Strawberry flavor8 Beet red0.02 Silica5 Magnesium stearate 5
[0048] 2. Preparation method:
[0049] The preparation method of this example is the same as that of example 1, in which "Isomalt" is used instead of "D-mannitol", "strawberry flavor" is used instead of "sweet orange flavor", and "beet red" is substituted for "sunset yellow". Aluminum Lake".
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