Recycling and reuse technology for preparing triphenylchloromethane

Abstract

The invention provides a recycling and reuse technology for preparing triphenylchloromethane. The technology comprises the following steps that hydrochloric acid or a mixture of the hydrochloric acidand Lewis acid is added into a solvent of triphenylcarbinol, stirring is conducted at a certain temperature, after a reaction is finished, separation is conducted, or after separation, recrystallization is further conducted, and the triphenylchloromethane is obtained after drying, wherein the reaction equation is shown in the description. The reuse technology is a recycling and reuse technology which is wide in raw material source, low in price and simple in production process operation and causes little pollution, and the technology is very suitable for commercialized production.

Description

Technical field [0001] The invention relates to a process for preparing triphenylmethyl chloride in a cycle, more specifically to a process for preparing triphenylchloromethane in a process of producing antihypertensive sartan drug intermediates [0002] technical background [0003] Triphenylchloromethane, white crystal, insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, n-hexane, slightly soluble in alcohol and ether, and becomes triphenylmethanol after absorbing water. Triphenylchloromethane is one of the basic organic raw materials commonly used in the field of medicine and chemical industry. In the process of organic chemical industry and drug synthesis, triphenylmethyl and its similar protecting groups are easy to up and down, and have mild conditions and high stability. With the characteristics of large steric hindrance, it has developed into one of the most commonly used amino or hydroxyl protecting groups, especially in the selective protecti...

AI Technical Summary

Problems solved by technology

[0010] 1. A large amount of sulfur dioxide and hydrogen chloride waste gas is generated during the production process, and tail gas absorption is required. A large amount of gas has high requirements for tail gas absorption. Generally, multi-stage series absorption is required. If the reaction speed is too fast, acid gas overflow will affect the production site environment and equipment ;

[0011] 2. The reaction of thionyl chloride requires proper heating, or a large excess of thionyl chloride, which brings a certain pressure to the post-treatment;

[0012] 3. There are many side reactions, low yield, easy to produce tar-like substances, and post-processing is very troublesome. Since the purity of recycled materials cannot be well guaranteed, the product purity is not ideal, and crystallization and purification are required.

These factors all restrict large-scale recycling

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