Difunctional polyurethane and preparation method and application thereof

A polyurethane and bifunctional technology, applied in the field of bifunctional polyurethane and its preparation, can solve the problem of inability to eliminate oxidative stress at the implantation site of blood vessels, and achieve the effects of good processability and relieving oxidative stress.
CN110283296AActive Publication Date: 2019-09-27CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2019-09-27

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Abstract

The invention relates to difunctional polyurethane and a preparation method and application thereof, and belongs to the technical field of biologic medical materials. The technical problem that an existing blood vessel material cannot eliminate oxidative stress of a blood vessel implant part is solved. The difunctional polyurethane contains a ligustrazine-nitrone group, and the structural formula of the ligustrazine-nitrone group is shown in the formula I. According to the difunctional polyurethane, by introducing a polyurethane molecular chain (tail end) into the ligustrazine-nitrone group with the dual functions of anti-oxidant and endothelial cell sticking promotion, the dual functions of polyurethane anti-oxidation and endothelial cell sticking promotion are given, adhesion and multiplication of endothelial cells can be effectively promoted, and the normal functions of the endothelial cells are promoted under the oxidation stress environment.
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Description

technical field

[0001] The invention relates to a bifunctional polyurethane and its preparation method and application, belonging to the technical field of biomedical materials.

[0002] technical background

[0003] In recent years, artificial blood vessels and stents have been widely used in the treatment of cardiovascular diseases. However, clinical studies have shown that due to the poor hemocompatibility of current vascular materials / stents, embolism and restenosis are prone to occur after implantation in the body, thus affecting the long-term application results. Since the vascular endothelium is a natural anticoagulant surface, it plays a vital role in the anticoagulation of blood vessels. Consequently, considerable research has been devoted to promoting rapid endothelialization of vascular materials.

[0004] In the prior art, there are mainly four methods for promoting rapid endothelialization of vascular materials: in vitro endothelialization of artificial blood v...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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