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A preparation method to achieve controllable release of chitosan/bright glue core capsules

A technology of gelatin-shell-core capsules and chitosan, which is applied in the direction of microcapsules, capsule delivery, medical preparations of non-active ingredients, etc., can solve problems such as limiting the application of chitosan-shell-core capsules, and achieve controllability, The effect of shortening the production cycle and mild preparation conditions

Active Publication Date: 2022-05-06
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this protocol is limited by the concentration of lipase, which limits the application of chitosan-shell core capsules in various environments

Method used

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  • A preparation method to achieve controllable release of chitosan/bright glue core capsules
  • A preparation method to achieve controllable release of chitosan/bright glue core capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of realizing the controllable release chitosan / gelatin shell core capsule provided by the present embodiment comprises the following specific steps:

[0031] (1) preparation of chitosan and sodium dodecylbenzenesulfonate solution:

[0032] Chitosan powder was added into 0.5% hydrochloric acid aqueous solution by volume percentage, stirred at room temperature for 5 hours until chitosan was fully dissolved, filtered using a Buchner funnel, and prepared to obtain a chitosan solution with a mass concentration of 1g / 100mL; Add 1g of sodium dodecylbenzenesulfonate powder into 50mL of deionized water, then stir for 2 hours until sodium dodecylbenzenesulfonate is fully dissolved, and prepare an anionic surfactant solution with a mass concentration of 2g / 100mL ;

[0033] (2) Prepare chitosanase / gelatin mixed solution:

[0034] Take 1.5g of gelatin and add it to 10mL of deionized water, stir at room temperature to make it fully swell, then place it in a c...

Embodiment 2

[0039] The preparation method of realizing the controllable release chitosan / gelatin shell core capsule provided by the present embodiment comprises the following specific steps:

[0040] (1) preparation of chitosan and sodium lauryl sulfate solution:

[0041] Chitosan powder was added into 0.2% hydrochloric acid aqueous solution by volume percentage, stirred at room temperature for 10 hours until chitosan was fully dissolved, filtered using a Buchner funnel, and prepared to obtain a chitosan solution with a mass concentration of 2g / 100mL; 3g of sodium lauryl sulfate powder was added to 100mL of deionized water, then stirred for 3 hours until the sodium lauryl sulfate was fully dissolved, and a sodium lauryl sulfate solution with a mass concentration of 3g / 100mL was prepared;

[0042] (2) Prepare chitosanase / gelatin mixed solution:

[0043] Add 4g of gelatin to 20mL of deionized water, stir at room temperature to make it fully swell, then transfer to a constant temperature wa...

Embodiment 3

[0048] The preparation method of realizing the controllable release chitosan / gelatin shell core capsule provided by the present embodiment comprises the following specific steps:

[0049] (1) preparation of chitosan and sodium dodecylbenzenesulfonate solution:

[0050] The chitosan powder is added into the hydrochloric acid aqueous solution of 0.6% by volume, stirred at room temperature for 7 hours until the chitosan is fully dissolved, filtered using a Buchner funnel, and prepared to obtain a chitosan solution with a mass concentration of 2g / 100mL; Add 2g of sodium dodecylbenzenesulfonate powder into 100mL of deionized water, then stir for 2 hours until sodium dodecylbenzenesulfonate is fully dissolved, and prepare an anionic surfactant solution with a mass concentration of 2g / 100mL ;

[0051] (2) Prepare chitosanase / gelatin mixed solution:

[0052] Take 3g of gelatin and add it to 30mL of deionized water, stir at room temperature to make it fully swell, then place it in a ...

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Abstract

A preparation method of chitosan / gelatin-shell core capsules for controlled release provided by the present invention is a preparation method for controlled release of chitosan / gelatin-shell core capsules under the synergistic response of temperature and enzyme, specifically: Firstly, gelatin microspheres loaded with chitosanase were prepared by using the temperature stimulus responsiveness of natural polymer gelatin; then gelatin microspheres were dispersed in chitosan solution, and cationic polyelectrolyte chitosan and anionic surfactant were used to The electrostatic attraction effect was further prepared to obtain chitosan / gelatin core-shell capsules. The gelatin, chitosan and chitosanase used in the method of the present invention are all natural polymer materials, have the characteristics of good biocompatibility, biodegradability, non-toxicity, abundant sources and low price; and the method has The preparation process is convenient, the steps are simple, the reaction time is short, easy to control, green and environmentally friendly, and the cost is low.

Description

technical field [0001] The invention belongs to the fields of polymer materials, biochemistry and biomedical materials, in particular to a preparation method of chitosan / gelatin shell-core capsules for controlled release, which can realize controlled release based on temperature and enzyme synergistic response Preparation of Chitosan / Gelatin Shell-Core Capsules. Background technique [0002] Polymer core-shell capsules are micro-containers prepared from one or more core and shell materials. The core materials include materials such as gas, liquid and solid; most of the shells are made of natural or synthetic polymer materials, and As a natural cationic dielectric polysaccharide obtained by deacetylation of chitin, chitosan has good biocompatibility, biodegradability, non-toxicity and biological activity, so chitosan-based shell-core capsules are used in drug delivery, enzyme immobilization Biomedical and biotechnology fields such as biosensors and bioreactors have broad app...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/42A61K47/36A61K9/50
CPCA61K9/5036A61K47/42
Inventor 陈艳军宋伟政贺光耀郑航王艺峰
Owner WUHAN UNIV OF TECH