Compound with phosphodiesterase 4D and acid sphingomyelinase inhibitory activity

A technology of compounds and mixtures, applied in the direction of organic active ingredients, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve problems such as aggravating depression symptoms, slow onset of action, and affecting the treatment effect of depression.
CN110305072AActive Publication Date: 2019-10-08CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2019-10-08

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Abstract

The invention discloses a compound with phosphodiesterase 4D and acid sphingomyelinase inhibitory activity. The compound has good PDE4D / ASM double-target inhibitory activity and can be used for preventing and / or treating diseases associated with the phosphodiesterase 4D and the acid sphingomyelinase, and the diseases particularly include inflammatory diseases, autoimmune diseases such as dermatitis, atopic dermatitis, psoriasis and multiple sclerosis, cardiovascular diseases such as atherosclerosis and ischemia reperfusion injury, hepatic diseases such as non-alcoholic steatohepatitis, alcoholic steatohepatitis and hepatic fibrosis, mental and neurological diseases such as depression and anxiety disorder, neurodegenerative diseases such as Alzheimer's diseases, respiratory system diseasessuch as chronic obstructive pulmonary diseases, cystic fibrosis, pulmonary fibrosis, pulmonary edema and lung injury and metabolic diseases such as diabetes.
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Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry, and specifically relates to a compound with phosphodiesterase 4D and acid sphingomyelinase inhibitory activity and application thereof. Background technique

[0002] Depression is a common mental illness. The clinical manifestations of patients are mainly depression, low mood, loss of interest in things, and severe cases have self-mutilation and suicide tendencies. With the accelerated pace of life, people are facing more and more pressure, the incidence of the disease is increasing year by year, and has the characteristics of high recurrence, high disability and high suicide rate, which seriously affects the quality of human life and economic development ( Journal of Ethnopharmacology, 2016, 194:819-826). According to the latest statistics from the World Health Organization, there are about 50 million depression patients in China, with an incidence rate of 4.2%; and there are 300 mi...

Claims

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