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A kind of medical degradable multilayer polymer/graphene film material and preparation method thereof

A technology for degrading polymers and graphene films, applied in the field of preparation of biodegradable materials, can solve problems such as the inability to adjust the mechanical strength and degradation time of materials according to actual needs, achieve controllable degradation time, good antibacterial function, and improve physical properties. barrier effect

Active Publication Date: 2021-01-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the existing technology, such as the inability to adjust the mechanical strength and degradation time of the material according to actual needs, etc.

Method used

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  • A kind of medical degradable multilayer polymer/graphene film material and preparation method thereof
  • A kind of medical degradable multilayer polymer/graphene film material and preparation method thereof
  • A kind of medical degradable multilayer polymer/graphene film material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Spin-coat 10mg / mL polylactic acid (PLA) solution onto the graphene / copper sheet with graphene at 3000rpm, and the spin-coating time is 30s; then etch the copper sheet in ammonium persulfate solution, at room temperature, The copper sheet was etched for 24 hours to obtain the PLA / graphene film.

[0030] 2) Transfer the PLA / graphene film to the surface of the graphene / copper sheet, make the PLA side stick to the graphene / copper sheet with the graphene side, let it dry naturally for 24 hours, and then etch the copper sheet in ammonium persulfate solution, A graphene / PLA / graphene film is obtained.

[0031] 3) On the prepared graphene / PLA / graphene film, ① spin coating or casting PLA solution to prepare a degradable polymer film ② transfer the obtained product to the surface of the graphene / copper substrate, so that the PLA side and the graphene / The graphene side of the copper sheet substrate is bonded, and the copper sheet is removed by etching; repeat ① and ② continuous...

Embodiment 2

[0034] (1) Spin-coat 50mg / mL polylactic acid (PLA) solution onto the graphene / copper sheet with graphene at 4000rpm, and the spin-coating time is 50s; then etch the copper sheet in ammonium persulfate solution, at room temperature, The copper sheet was etched for 6h to obtain the PLA / graphene film.

[0035] 2) Transfer the PLA / graphene film to the surface of the graphene / copper sheet, make the PLA side stick to the side of the graphene / copper sheet with graphene, let it dry naturally for 12 hours, and then etch the copper sheet in ammonium persulfate solution, A graphene / PLA / graphene film is obtained.

[0036] 3) On the prepared graphene / PLA / graphene film, ① spin coating or casting PLA solution to prepare a degradable polymer film ② transfer the obtained product to the surface of the graphene / copper substrate, so that the PLA side and the graphene / The graphene side of the copper sheet substrate is bonded, and the copper sheet is removed by etching; repeat ① and ② continuousl...

Embodiment 3

[0039] (1) Spin-coat 25mg / mL polylactic acid (PLA) solution onto the graphene / copper sheet with graphene at 3500rpm, and the spin-coating time is 40s; then etch the copper sheet in ammonium persulfate solution, at room temperature, The copper sheet was etched for 12 hours to obtain a PLA / graphene film.

[0040] 2) Transfer the PLA / graphene film to the surface of the graphene / copper sheet, make the PLA side stick to the side of the graphene / copper sheet with graphene, let it dry naturally for 18 hours, and then etch the copper sheet in ammonium persulfate solution, A graphene / PLA / graphene film is obtained.

[0041] 3) On the prepared graphene / PLA / graphene film, ① spin coating or casting PLA solution to prepare a degradable polymer film ② transfer the obtained product to the surface of the graphene / copper substrate, so that the PLA side and the graphene / The graphene side of the copper sheet substrate is bonded, and the copper sheet is removed by etching; repeat ① and ② continu...

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Abstract

The invention discloses a medical degradable multilayer polymer / graphene film material and a preparation method thereof. The method includes firstly attaching a biodegradable polymer to a single-layergraphene / Cu substrate by spin coating or casting; then removing Cu through etching to obtain polymer / single-layer graphene film; and laminating a plurality of layers of the polymer / single-layer graphene film to obtain the multilayer polymer / graphene film. The polymer is good in biocompatibility with graphene and is degradable in vivo, and the degradation time of the disclosed film material can beadjusted and controlled through controlling the number of layers of the polymer / graphene film. In addition, the multilayer polymer / graphene film has high mechanical strength, and is corrosion resistant and antibacterial. The preparation method is simple. The multilayer polymer / graphene film material is expected to be applied in clinical surgical suture supporting materials and surface modification of implants.

Description

technical field [0001] The invention relates to the preparation of biodegradable materials in the field of biomedicine, in particular to a medical degradable multi-layer polymer / graphene film material and its preparation method, which is expected to be applied to suturing support materials and implant surfaces in clinical operations modified. Background technique [0002] The existing medical sutures and patches mainly use sheep casings, polymer chemical synthesis threads, etc., which have disadvantages such as unsatisfactory mechanical strength and too long or too short degradation and absorption time. [0003] Graphene (Graphene) and its derivatives (graphene oxide and reduced graphene oxide) are widely used in tissue engineering, biological Sensing, disease diagnosis, antibacterial and antiviral materials, cancer targeting and photothermal therapy, drug delivery, electrical stimulation of cells, etc. show great potential. Many studies have found that low concentration o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/14A61L17/12
CPCA61L17/12A61L17/145
Inventor 程逵龙小军翁文剑
Owner ZHEJIANG UNIV
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