The invention discloses a pulse diagnosis instrument, which comprises a positioning component independently fixed at the wrist of hand, wherein the positioning component is provided with a visible positioning window. The pulse diagnosis instrument further comprises a sensor component which is arranged on the positioning component, wherein a sensor probe of the sensor component is positioned in the positioning window after being assembled. The pulse diagnosis instrument has the advantages that: 1) the positioning process is visible and the positioning window is provided with marks, so the positioning is more accurate, 2) the positioning component is independently fixed at the wrist of hand and is fixed at the position opposite to the wrist, so as to prevent the measuring position from gearing caused by the rotation of the wrist, 3) the part of the positioning component fit with the hand is arc side stuck with a medical silica gel layer, and two arc-shaped elastic sheets can ensure the comfortableness and stability of the fixing between the positioning component and the wrist, and 4) a tension spring structure is used as a pulse pillow, which is prevented from being lost caused by separating from the base in using process, can freely rotate and realizes the convenient conversion of the pulse collection of left and right hands.