Method for regulating morphology of hydroxyapatite micro-nanomaterial by using phosphorus source

A technology for regulating hydroxyapatite and hydroxyapatite, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problems of difficult to meet the practical application requirements of mass production, complex synthesis methods, etc. The effect of universality, simple operation method and high yield

Active Publication Date: 2019-10-15
SHANDONG JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has been reported that the synthesis method of hydroxyapatite material is relatively complicated, and it is difficult to meet the actual application requirements of mass production.
Up to now, there is no method in the field to prepare hydroxyapatite micro-nano materials with various shapes such as linear, rod, spherical and tubular in one step only by changing the phosphorus source under the same synthesis system

Method used

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  • Method for regulating morphology of hydroxyapatite micro-nanomaterial by using phosphorus source
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  • Method for regulating morphology of hydroxyapatite micro-nanomaterial by using phosphorus source

Examples

Experimental program
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Effect test

Embodiment 1

[0060] A method for regulating the morphology of hydroxyapatite micro-nano material by using a phosphorus source, mainly comprising the following steps:

[0061] In a water bath at 60°C, mix 6.00g of absolute ethanol and 6.00g of brown keto acid, and stir for 3min under magnetic stirring at 300r / min to mix the two evenly; An aqueous solution of calcium and 10 ml of an aqueous solution containing 0.50 g of sodium hydroxide form a saturated calcium palmitate precursor; under stirring conditions, add 5 ml of an aqueous solution containing 0.442 g of sodium phosphate dodecahydrate dropwise, and wait until the sodium phosphate dodecahydrate has been added dropwise After the aqueous solution, the reaction solution was transferred to a hydrothermal reaction kettle, heated to 180° C., and then solvothermally reacted for 5 hours. When the hydrothermal reaction kettle is cooled to room temperature with the furnace, the reaction product is transferred, washed alternately with alcohol and...

Embodiment 2

[0064] A method for regulating the morphology of hydroxyapatite micro-nano material by using a phosphorus source, mainly comprising the following steps:

[0065] In a water bath at 60°C, mix 6.00g of absolute ethanol and 6.00g of brown keto acid, and stir for 3min under magnetic stirring at 300r / min to mix the two evenly; The aqueous solution of calcium and 10ml containing the aqueous solution of 0.50g sodium hydroxide form the calcium palmitate precursor; Add dropwise the aqueous solution of 5ml containing 0.375g sodium trimetaphosphate under stirring condition, after treating that the aqueous solution of sodium trimetaphosphate is added dropwise, The reaction liquid was transferred to a hydrothermal reaction kettle, heated to 180° C., and then reacted by solvothermal reaction for 5 h. When the hydrothermal reaction kettle is cooled to room temperature with the furnace, the reaction product is transferred, washed alternately with alcohol and deionized water for several times,...

Embodiment 3

[0068] A method for regulating the morphology of hydroxyapatite micro-nano material by using a phosphorus source, mainly comprising the following steps:

[0069] In a water bath at 60°C, mix 6.00g of absolute ethanol and 6.00g of brown keto acid, and stir for 3min under magnetic stirring at 300r / min to mix the two evenly; The aqueous solution of calcium and 10ml containing the aqueous solution of 0.50g sodium hydroxide form the calcium palmitate precursor; Add dropwise the aqueous solution of 5ml containing 0.143g sodium tripolyphosphate under stirring condition, after treating that the aqueous solution of sodium tripolyphosphate is added dropwise, The reaction liquid was transferred to a hydrothermal reaction kettle, heated to 180° C., and then reacted by solvothermal reaction for 5 h. When the hydrothermal reaction kettle was cooled to room temperature with the furnace, the reaction product was transferred, washed alternately with alcohol and deionized water for several time...

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Abstract

The invention relates to a method for regulating the morphology of a hydroxyapatite micro-nanomaterial by using a phosphorus source. The method comprises the following steps: mixing anhydrous ethanoland palmitic acid, adding an aqueous solution of a soluble calcium salt and an aqueous solution of a strong alkali, and performing magnetic stirring until uniformity in order to prepare a calcium palmitate precursor; adding an aqueous solution of various phosphorus sources such as a phosphate dodecahydrate, a trimetaphosphate, a tripolyphosphate, and a hexametaphosphate to obtain a reaction solution, adding the reaction solution into a hydrothermal kettle, and carrying out a solvothermal reaction; and washing and drying the obtained reaction product to obtain the hydroxyapatite micro-nanomaterial with various morphologies such as a ultra-long nanowire, a nano-short rod, a petal-like microsphere and a micro-tube. The method can be used to conveniently and quickly obtain the hydroxyapatite micro-nanostructure with the controlled morphology, and the hydroxyapatite micro-nanomaterial can be applied to many fields of bone tissue repairing, suture, hemostatic dressings, adsorption bioactivesubstances, drug loading and release, bone filling and cell / drug loaded implants according to actual needs.

Description

technical field [0001] The invention belongs to the technical field of synthesis of inorganic biological materials, and relates to a method for regulating the morphology of hydroxyapatite micro-nano materials by utilizing a phosphorus source. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Hydroxyapatite (Hydroxyapatite, chemical formula (Ca 10 (PO 4 ) 6 (OH) 2 ), has excellent biocompatibility and biological activity, and many characteristics such as non-toxic, non-irritating and difficult to be phagocytized by cells, and is currently the most ideal inorganic biomaterial in clinical applications. [0004] The hydroxyapatite material with a micro-nano structure, espec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
CPCC01B25/325C01P2004/16C01P2004/30C01P2004/32C01P2004/61C01P2004/62C01P2004/64
Inventor 齐美丽秦思佳南祥凯杨秋松王彦敏刘小村陈敏
Owner SHANDONG JIAOTONG UNIV
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