Medical polyurethane material containing lactone group, preparation method thereof, and medical catheter

Abstract

The present invention provides a medical polyurethane material containing a lactone group, and a medical catheter prepared therefrom. The medical polyurethane material is prepared by polycondensing 4,4'-diphenylmethane diisocyanate, butanediol, polytetrahydrofuran and a butyrolactone group-containing substance; and the butyrolactone group-containing substance contains at least two hydroxyl groups,and the molar concentration of the butyrolactone group in the medical polyurethane material is 5-20 mmol / g. The lactone group is in a closed-loop state when the medical polyurethane material is in adry state, and can maintain the hydrophobicity of the polyurethane and does not affect the extrusion molding of the polyurethane material, and the lactone group undergoes a hydrolysis ring-opening reaction in an aqueous environment or in the human body to increase the hydrophilicity of the polyurethane material and significantly reduce the elastic modulus of the polyurethane material, so the medical catheter prepared from the material has a high rigidity in vitro, and the softness is significantly increased after entering human blood vessels.

Description

technical field [0001] The invention belongs to the technical field of biomedical polyurethane materials, and in particular relates to a medical polyurethane material containing lactone groups, a preparation method thereof and a medical catheter. Background technique [0002] Medical catheters refer to high-end precision medical devices used to transport gases, liquids and solids into the body during disease treatment. After decades of development, medical interventional catheters play a role in the treatment of various diseases in the medical field today. more and more important. In addition to having good biocompatibility, raw materials for medical catheters must also have special mechanical properties. [0003] Taking intravenous indwelling needle catheter as an example, in order to reduce the intensity of mechanical stimulation of the catheter tip to human tissue and reduce the incidence of complications such as inflammation, pain, thrombus, and drug penetration at the ...

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Problems solved by technology

The disadvantage of this type of catheter is that the inner diameter of the catheter is significantly reduced after absorbing water, resulting in a decrease in the input flow rate of the liquid medicine, which is not conducive to the rapid treatment of diseases, and the melt extrusion process of polyurethane materials is extremely sensitive to water, and the introduction of hydrophilic groups , increasing the difficulty of the drying process of polyurethane materials

The U.S. patent with the publication number US5281677 and the Chinese patent with the authorization number ZL201310302169.8 respectively propose methods for preparing medical interventional catheters using polyurethane blends. They adopt different technical routes. After the prepared blends are processed into catheters, When placed at room temperature, it has rigidity that is conducive to puncture. After entering the human body, the elastic modulus can be reduced by 70-88%, and there will be no water swelling phenomenon, thereby significantly reducing the degree of mechanical stimulation of the catheter to the tissue. However, this Method does not soften enough in vivo relative to hydrophilic polyurethane materials

Publication No. US4156067 uses six-carbon saccharide to prepare alkali water-soluble polyurethane material, but the six-carbon saccharactone in this material contains more than two hydroxyl groups, and the resulting polyurethane material has a cross-linked structure , no thermoplastic processability

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