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Nutritional supplements capable of preventing and protecting against osteoporosis

A technology for nutritional supplements and osteoporosis, which is applied to bone diseases, the function of food ingredients, and medical preparations containing active ingredients.

Inactive Publication Date: 2019-10-18
北京奥萨医药研究中心有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And its form cannot be absorbed by the body

Method used

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  • Nutritional supplements capable of preventing and protecting against osteoporosis
  • Nutritional supplements capable of preventing and protecting against osteoporosis
  • Nutritional supplements capable of preventing and protecting against osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1: Vitamin A Vitamin B12 Vitamin D Vitamin E Tablets

[0031] Components:

[0032]

[0033]

[0034] 160ug of vitamin A, 5ug of vitamin B12, 5ug of vitamin D and 50mg of vitamin E are mixed with 76mg of microcrystalline cellulose, and 16mg of croscarmellose sodium is added to the obtained mixed solution to obtain a mixed powder. Add 24mg of povidone K30 and a wetting agent (water or ethanol) mixed solution to the mixed powder, add 25ml mixed solution for every 100mg mixed powder to bond evenly, it is advisable to hold it into a ball and it will be scattered when touched. Granulate with 18 mesh sieve. The wet granules are dried at a temperature of 60°C for 4 hours, and the moisture content is controlled to be less than or equal to 7%. The dried granules are passed through a 18-mesh sieve to obtain dry granules. Add magnesium stearate and mix for 10 minutes to obtain total mixed granules. The total mixed granules are compressed into tablets to obtain tab...

Embodiment 2

[0035] Embodiment 2: vitamin A vitamin B12 vitamin D vitamin E soft capsule

[0036] Components:

[0037]

[0038] Preparation method: add beeswax to soybean oil, heat at 50°C to dissolve the beeswax, place it at room temperature, add vitamin A, vitamin B12, vitamin D and vitamin E to soybean oil to make a suspension, and set aside. In addition, gelatin, purified water, caramel color, and parabens are prepared into a glue solution, and the prepared suspension is pressed into pills by a pill press to make soft capsules. After shaping, pill washing and drying, it is prepared Get this soft capsule.

Embodiment 3

[0039] Embodiment 3: vitamin A vitamin B12 vitamin D vitamin E hard capsule

[0040] Components:

[0041]

[0042] Preparation method: mix vitamin AD with 20% microcrystalline cellulose, sieve, then add vitamin E and vitamin B12 to mix, mix the obtained raw material mixture with the remaining amount of microcrystalline cellulose in equal increments, then add lactose, hard Magnesium fatty acid is mixed, then filled with a full-automatic capsule filling machine, and polished to obtain the hard capsule of the pharmaceutical composition of the present invention.

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Abstract

The invention relates to nutritional supplements and a preparation method thereof. The nutritional supplements consist of 100-800 micrograms of vitamin A, 5-20 micrograms of vitamin B12, 1.5-10 micrograms of vitamin D and 5-150 milligrams of vitamin E, and have the effects of preventing and protecting against osteoporosis; and the nutritional supplements are especially suitable for pregnant patients. The composition, namely the nutritional supplements, provided by the invention can be prepared into nutritious products or health foods, and can be used for preparing pharmaceuticals.

Description

technical field [0001] The invention relates to a nutritional supplement with protective effect on osteoporosis, which contains vitamin A, vitamin B12, vitamin D and vitamin E. The supplement is also suitable for making health food. Background technique [0002] Osteoporosis is a systemic bone disease in which bone density and bone quality decrease due to various reasons, bone microstructure is destroyed, bone fragility increases, and fractures are prone to occur. Osteoporosis is divided into primary and secondary two categories. Primary osteoporosis is divided into three types: postmenopausal osteoporosis (type I), senile osteoporosis (type II) and idiopathic osteoporosis (including juvenile type). Zhang Zhihai disclosed that in the age group of 40-50 years old, the incidence rate of osteoporosis in women is 6.37%±2.39%, and the incidence rate of osteoporosis in men is 4.11%±1.70%; in the age group of 50-60 years old, the incidence rate of osteoporosis in women is 21.75% ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L33/155A61K31/07A61K31/714A61K31/59A61K31/355A61P19/10A61P3/02
CPCA23L33/15A23L33/155A61K31/07A61K31/714A61K31/59A61K31/355A61P19/10A61P3/02A23V2002/00A23V2200/306A23V2250/702A23V2250/706A23V2250/714A61K2300/00
Inventor 徐希平张磊于多陈平
Owner 北京奥萨医药研究中心有限公司
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