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Cannabidiol-contained composition for treating face neuritis and preparation method of cannabidiol-contained composition

A technology for facial neuritis and cannabidiol, which is applied in the field of compositions containing cannabidiol and its preparation, can solve the problems of large side effects, slow effect and the like, achieves high drug loading, restores nutrient supply, and promotes nerve regeneration. Effect

Pending Publication Date: 2019-11-12
李卫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems of slow effect and large side effects of the existing facial neuritis treatment methods, the present invention provides a composition containing cannabidiol for the treatment of facial neuritis and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This example provides a composition containing cannabidiol for treating facial neuritis, which mainly includes the following components by mass: 1-10 parts of cannabidiol, 1-6 parts of total flavonoids of safflower, and total 1-6 parts of saponin, 1-8 parts of deer antler polypeptide, 45-70 parts of chitosan, 100-135 parts of sodium alginate, 500-1500 parts of γ-polyglutamic acid, 1000-2000 parts of hyaluronic acid, cascara 100-300 parts of glycolipid, 25-400 parts of dopamine hydrochloride.

[0036] The composition for treating facial neuritis provided in this example contains cannabidiol, total flavonoids of safflower, total saponins of astragalus and velvet antler polypeptide as main active ingredients, wherein cannabidiol has antioxidant effect and is a natural nerve Protective agent, which can reduce oxidative stress, prevent facial neuron necrosis, repair facial nerve damage, and reduce the risk of ischemic injury; safflower total flavonoids can expand blood vesse...

Embodiment 2

[0038] This example provides a composition containing cannabidiol for treating facial neuritis, which mainly includes the following components by mass: 10 parts of cannabidiol, 6 parts of total flavonoids of safflower, 6 parts of total saponins of astragalus, 8 parts of deer antler polypeptide, 45 parts of chitosan, 125 parts of sodium alginate, 700 parts of γ-polyglutamic acid, 1000 parts of hyaluronic acid, 100 parts of rhamnolipid, 50 parts of dopamine hydrochloride.

[0039] The mass concentration of cannabidiol in the composition obtained in this example is 1%, the mass concentration of safflower total flavonoids is 0.6%, the mass concentration of total astragalus saponins is 0.6%, and the mass concentration of antler polypeptide is 0.8%.

Embodiment 3

[0041] This example provides a composition containing cannabidiol for treating facial neuritis, which mainly includes the following components by mass: 1 part of cannabidiol, 1 part of safflower total flavonoids, 1 part of astragalus total saponins, 1 part of deer antler polypeptide, 65 parts of chitosan, 133 parts of sodium alginate, 500 parts of γ-polyglutamic acid, 1200 parts of hyaluronic acid, 150 parts of rhamnolipid, 25 parts of dopamine hydrochloride.

[0042] The mass concentration of cannabidiol in the composition obtained in this example is 0.1%, the mass concentration of safflower total flavonoids is 0.1%, the mass concentration of total astragalus saponins is 0.1%, and the mass concentration of velvet antler polypeptide is 0.1%.

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Abstract

The invention relates to a cannabidiol-contained composition for treating face neuritis and a preparation method of the cannabidiol-contained composition, and belongs to the technical field of medicalcompositions. In order to solve the problems that an existing face neuritis treatment method takes effect slowly and is large in side effects, the invention provides the cannabidiol-contained composition for treating face neuritis. The cannabidiol-contained composition for treating face neuritis is prepared through the steps of with cannabidiol, safflower total flavonoids, radix astragali total saponins and cornu cervi pantotrichum polypeptide as main effective components, firstly loading the main effective components on composite microspheres formed from chitosan and sodium alginate, and uniformly dispersing the medicine-loading composite microspheres in hydrogel formed from hyaluronic acid-dopamine under the action of rhamnolipid and poly gamma-glutamic acid, so as to obtain a gel composition. The composition disclosed by the invention is high in medicine loading quantity, high in biocompatibility, free from toxicity and free from stimulation to skin; and after the composition is applied to the face of a patient, effective medicine components directly permeate into damage nerves at skin bottom, microcirculation is quickly improved, the damaged nerves are repaired, neurotizationis promoted, and the functions of facial muscle are restored.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compositions, and in particular relates to a composition containing cannabidiol for treating facial neuritis and a preparation method thereof. Background technique [0002] Facial neuritis, also known as facial nerve palsy, commonly known as facial paralysis, has no age limit for onset. Symptoms are crooked mouth, slanted eyes, weird facial expressions, slurred speech, drooling, etc., which seriously affect the daily life and image of patients. Facial neuritis is caused by facial nerve damage, most of which are nerve damage caused by ischemia, edema, and compression of facial nerve tissue caused by spasm of the blood vessels of the facial nutrient nerve due to wind and cold. [0003] If facial neuritis is not treated properly, it will leave sequelae in varying degrees, so it should be treated in time after discovery. Western medicine mainly treats with western medicines for dehydration, de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K9/06A61K47/36A61K47/34A61P25/02A61K31/05A61K36/481
CPCA61K38/012A61K36/481A61K36/286A61K31/05A61K9/06A61K9/0014A61K47/36A61K47/34A61P25/02A61K2236/19A61K2236/55A61K2236/333A61K2236/51A61K2300/00
Inventor 孟鑫孟庆刚李卫赵立涛孙宇峰吕明明付荣太杜继伟岳琦李宝林
Owner 李卫
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