A kind of antibacterial/antifouling/antifogging coating based on quaternary ammonium salt and n-hydroxyacrylamide blend and preparation method thereof

A technology of hydroxyalkylacrylamide and anti-fog coating, which is applied in the field of antibacterial/anti-fouling/anti-fog coating and its preparation, to achieve good compatibility, improve poor biocompatibility, and good application prospects

Active Publication Date: 2021-06-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the problems of bacterial infection, blood contamination and atomization caused by the complex environment of medical implants such as endoscopes, the present invention provides an antibacterial / antibacterial agent based on a blend of quaternary ammonium salt and N-hydroxyacrylamide Stain / anti-fog coating and preparation method thereof

Method used

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  • A kind of antibacterial/antifouling/antifogging coating based on quaternary ammonium salt and n-hydroxyacrylamide blend and preparation method thereof
  • A kind of antibacterial/antifouling/antifogging coating based on quaternary ammonium salt and n-hydroxyacrylamide blend and preparation method thereof
  • A kind of antibacterial/antifouling/antifogging coating based on quaternary ammonium salt and n-hydroxyacrylamide blend and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Synthesis of POSS-poly(methacryloxyethyl dimethyl butyl ammonium bromide-co-methacrylic acid-2-aminoethyl ester):

[0040] Dissolve monoamino POSS, 4-cyanopentanoic acid dithiobenzoic acid, methylaminopropylcarbodiimide hydrochloride, and 4-dimethylaminopyridine in a molar ratio of 1.2:1:3:0.6 in two In methyl chloride, it was configured as a 30% solution, and reacted at room temperature for 12 hours under a nitrogen atmosphere. After the reaction was completed, the solvent was removed, and the column chromatography was performed using a petroleum ether / ethyl acetate system with a volume ratio of 4:1 as an eluent to collect pink The colored substance was dried in vacuum to obtain POSS modified 4-cyanopentanoic acid dithiobenzoic acid.

[0041] Add azobisisobutyronitrile, POSS modified 4-cyanopentanoic acid dithiobenzoic acid, methacryloyloxyethyl dimethyl butyl ammonium bromide, and 2-aminoethyl methacrylate by mole Dissolved in ethanol at a ratio of 0.25:1:200:50,...

Embodiment 2

[0050] (1) Synthesis of POSS-poly(methacryloyloxyethyltrimethylammonium bromide-co-methacrylic acid-2-aminoethyl ester):

[0051] Dissolve monoamino POSS, 4-cyanopentanoic acid dithiobenzoic acid, methylaminopropylcarbodiimide hydrochloride, and 4-dimethylaminopyridine at a molar ratio of 2:1:3:1 in two In methyl chloride, it was configured as a 20% solution, and reacted at room temperature for 24 hours under a nitrogen atmosphere. After the reaction, the solvent was removed, and the volume ratio of 3:1 petroleum ether / ethyl acetate system was used as an eluent for column chromatography to collect pink The colored substance was dried in vacuum to obtain POSS modified 4-cyanopentanoic acid dithiobenzoic acid.

[0052] Azobisisobutyronitrile, POSS modified 4-cyanopentanoic acid dithiobenzoic acid, methacryloyloxyethyltrimethylammonium bromide, and methacrylic acid-2-aminoethyl in molar ratio are 0.25:1:500:50 is dissolved in ethanol and prepared as a 30% solution. After the fre...

Embodiment 3

[0061] (1) Synthesis of POSS-poly(methacryloxyethyl dimethyl heptadecyl ammonium bromide-co-methacrylic acid-2-aminoethyl ester):

[0062] Dissolve monoamino POSS, 4-cyanopentanoic acid dithiobenzoic acid, methylaminopropylcarbodiimide hydrochloride, and 4-dimethylaminopyridine at a molar ratio of 4:1:6:2 in two In methyl chloride, it was configured as a 40% solution, and reacted at room temperature for 12 hours under a nitrogen atmosphere. After the reaction was completed, the solvent was removed, and the column chromatography was carried out using a petroleum ether / ethyl acetate system with a volume ratio of 6:1 as an eluent to collect pink The colored substance was dried in vacuum to obtain POSS modified 4-cyanopentanoic acid dithiobenzoic acid.

[0063] Azobisisobutyronitrile, POSS modified 4-cyanopentanoic acid dithiobenzoic acid, methacryloyloxyethyl dimethyl heptadecyl ammonium bromide, 2-aminoethyl methacrylate Dissolve in ethanol at a molar ratio of 0.25:1:200:20, an...

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Abstract

The invention discloses an antibacterial / antifouling / antifog coating based on a blend of quaternary ammonium salt and N-hydroxyacrylamide and a preparation method thereof. First, two copolymers of POSS-poly(quaternary ammonium salt cation-co-methacrylate-2-aminoethyl acrylate) and poly(N-hydroxyacrylamide-co-glycidyl methacrylate) were synthesized respectively, and then It is blended with trimesaldehyde and cured by heat to form a film. A quaternary ammonium cationic copolymer in the coating for sterilization; poly(N-hydroxyacrylamide-co-glycidyl methacrylate) provides antibacterial and protein-adhesive properties; hydrophilic groups in both copolymers Endow the coating with good anti-fog performance; the introduction of hydrophobic POSS is beneficial to improve the mechanical properties of the coating such as water resistance stability, thermal stability and wear resistance. The coating preparation process of the invention is simple, the two copolymers have good compatibility, and has potential application prospects in the field of medical devices.

Description

technical field [0001] The invention belongs to the field of polymer material coatings, and in particular relates to an antibacterial / antifouling / antifogging coating based on a blend of quaternary ammonium salt and N-hydroxyacrylamide and a preparation method thereof. Background technique [0002] In recent years, minimally invasive surgical treatment has attracted more and more attention due to its advantages of low risk and fast recovery. During the treatment process, the imaging capability of the endoscopic lens is crucial. Bacteria, blood, etc. adhere to and pollute the surface of the lens, which may cause bacterial infection while reducing the transparency of the lens itself, thereby affecting the surgical effect. In addition, due to the temperature difference between the operating room and the human body, and the relatively high humidity inside the human body (>90% RH), it is very easy to fog the lens during the operation. Therefore, there is an urgent need to pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D5/14C09D5/16C09D187/00C09D133/24C08G81/02C08F220/58C08F220/32C08J3/24
CPCC08F220/58C08G81/024C08J3/246C08J2387/00C08J2433/24C09D5/14C09D5/1662C09D187/005C08L33/24
Inventor 袁晓燕白珊李晓晖朱孔营赵蕴慧任丽霞
Owner TIANJIN UNIV
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