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A kind of multifunctional calcium-silicon-based rare earth doped bioactive powder and its preparation method and application

A bioactive, rare-earth-doped technology, applied in a multifunctional calcium-silicon-based rare-earth-doped photothermal-fluorescence-field, can solve problems such as the inability to monitor the temperature of materials in deep tissues, and achieve great application potential and good fluorescence performance. , the effect of reducing damage

Active Publication Date: 2022-03-08
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, general photothermal therapy usually uses a thermal imager to measure the surface temperature of the tumor site, and cannot monitor the specific temperature of materials in deep tissues

Method used

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  • A kind of multifunctional calcium-silicon-based rare earth doped bioactive powder and its preparation method and application
  • A kind of multifunctional calcium-silicon-based rare earth doped bioactive powder and its preparation method and application
  • A kind of multifunctional calcium-silicon-based rare earth doped bioactive powder and its preparation method and application

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preparation example Construction

[0042] Preparation of bioactive glass powders. In one embodiment of the present invention, a container-less air suspension method is used to prepare multifunctional bioactive glass powder. Specifically, the bioactive powder prepared by co-precipitation is pressed into a ceramic tablet of a certain shape with a mold of a tablet machine (for example, a diameter of 6 mm). Then put the ceramic sheet into a containerless air suspension furnace, feed oxygen to suspend the ceramic sheet, and use carbon dioxide (CO 2 ) laser melting the obtained ceramic sheet to obtain a melt. Then cool at a speed of 300K / S (the cooling process is to disconnect the laser light source, and then the cooling process is mainly controlled by the cooling system), and finally form bioactive glass spheres. The biological activity is then rapidly heated to 400-600°C (eg, 500°C), removed, rapidly poured into deionized water, quenched, and then ground in an agate mortar. The obtained ground powder is further ...

Embodiment 1

[0051] (1) sodium silicate nonahydrate (Na 2 SiO 3 9H 2 O) solution was added dropwise to calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) Dissolved in deionized water to obtain pure calcium silicate (CS) co-precipitated powder, magnetically stirred for 12 hours, then vacuum filtered, washed with deionized water and absolute ethanol for 3 times, and then placed in a 60°C oven for 48 Hour;

[0052] (2) Adopting a grinding tool with a diameter of 6mm to press the powder into a block, put it into an air suspension furnace to melt and cool it into a glass ball (the parameters of the container-free air suspension include: the throat diameter of the nozzle is 2mm; the laser power is 50W ; The holding time is 100 seconds; the gas used is oxygen, and the gas pressure is 0.8MPa). Then quickly heat up to 500°C, take it out and immediately pour it into deionized water to quench, put it into an agate mortar and grind it into powder, and pass it through a 200-mesh sieve to obtain mi...

Embodiment 2

[0056] (1) 56.84g sodium silicate nonahydrate (Na 2 SiO 3 9H 2 O) solution is added dropwise to 21.2535g calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) and 4.3835g neodymium nitrate hexahydrate (Nd(NO 3 ) 3 ·6H 2 O) In the mixed solution, a multifunctional biomaterial (Nd / CS1) with a neodymium doping content of 1.9 at% of Ca:Nd=9:1 was obtained. Stir magnetically for 12 hours, then vacuum filter, then wash with deionized water and absolute ethanol for 3 times, and then place in an oven at 60°C for 48 hours;

[0057] (2) Adopting a grinding tool with a diameter of 6mm to press the powder into a block, put it into an air suspension furnace to melt and cool it into a glass ball (the parameters of the container-free air suspension include: the throat diameter of the nozzle is 2mm; the laser power is 50W ; The holding time is 100 seconds; the gas used is oxygen, and the gas pressure is 0.8MPa). Then quickly heat up to 500°C, take it out and immediately pour it into deio...

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Abstract

The present invention relates to a multifunctional calcium-silicon-based rare earth-doped biologically active powder and its preparation method and application. The calcium-silicon-based rare-earth-doped biologically active powder contains at least Ca, Si ions and Nd ions, preferably Nd-doped calcium silicate bioactive powder, the doping content of Nd ions is 1.5 at% to 5.6 at%. The Nd-doped calcium-silicon-based bioactive material provided by the invention can be used to treat tumors and detect temperature in deep tissues, and has great application prospects.

Description

technical field [0001] The invention relates to a multifunctional calcium-silicon-based rare earth-doped bioactive powder and its preparation method and application, in particular to a multifunctional calcium-silicon-based rare earth-doped bioactive material for photothermal-fluorescence-temperature monitoring and its The preparation method, and the material can be used to treat solid tumors while monitoring temperature, so as to treat tumors with minimal tissue damage, and belong to the field of biotechnology. Background technique [0002] Tumor treatment is a difficult problem in the field of medicine. Compared with traditional treatment methods, photothermal therapy has unique advantages. However, general photothermal therapy usually uses a thermal imager to measure the surface temperature of the tumor site, which cannot monitor the specific temperature of the material in the deep tissue. Excessive heat can damage surrounding healthy tissue. In addition, the optimal tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C6/02C03C4/00A61K41/00A61K49/00A61P35/00
CPCC03C1/00C03C4/0007A61K41/0052A61K49/0019A61P35/00
Inventor 常江马玲玲
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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